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851.
Serap ?uhadar Mehmet K?seo?lu Yasemin ?inpolat Güler Bu?dayc? Murat Usta Tuna Semerci 《Biochemia medica : ?asopis Hrvatskoga dru?tva medicinskih biokemi?ara / HDMB》2016,26(1):53-60
Introduction
Extremely high glucose concentrations have been shown to interfere with creatinine assays especially with Jaffe method in peritoneal dialysate. Because diabetes is the fastest growing chronic disease in the world, laboratories study with varying glucose concentrations. We investigated whether different levels of glucose spiked in serum interfere with 21 routine chemistry and thyroid assays at glucose concentrations between 17-51 mmol/L.Materials and methods
Baseline (group I) serum pool with glucose concentration of 5.55 (5.44-5.61) mmol/L was prepared from patient sera. Spiking with 20% dextrose solution, sample groups were obtained with glucose concentrations: 17.09, 34.52, and 50.95 mmol/L (group II, III, IV, respectively). Total of 21 biochemistry analytes and thyroid tests were studied on Abbott c8000 and i2000sr with commercial reagents. Bias from baseline value was checked statistically and clinically.Results
Creatinine increased significantly by 8.74%, 31.66%, 55.31% at groups II, III, IV, respectively with P values of < 0.001. At the median glucose concentration of 50.95 mmol/L, calcium, albumin, chloride and FT4 biased significantly clinically (-0.85%, 1.63%, 0.65%, 7.4% with P values 0.138, 0.214, 0.004, < 0.001, respectively). Remaining assays were free of interference.Conclusion
Among the numerous biochemical parameters studied, only a few parameters are affected by dramatically increased glucose concentration. The creatinine measurements obtained in human sera with the Jaffe alkaline method at high glucose concentrations should be interpreted with caution. Other tests that were affected with extremely high glucose concentrations were calcium, albumin, chloride and FT4, hence results should be taken into consideration in patients with poor diabetic control.Key words: assay interference, glucose interference, preanalytical phase, creatinine, Jaffe kinetic assay, thyroid function tests 相似文献852.
Chandrawati Kumari Bijo Varughese Siddarth Ramji Seema Kapoor 《Indian journal of clinical biochemistry : IJCB》2016,31(4):414-422
Pre analytical process of extraction for accurate detection of organic acids is a crucial step in diagnosis of organic acidemias by GCMS analysis. This process is accomplished either by solid phase extraction (SPE) or by liquid–liquid extraction (LLE). Both extraction procedures are used in different metabolic laboratories all over the world. In this study we compared these two extraction procedures in respect of precision, accuracy, percent recovery of metabolites, number of metabolites isolated, time and cost in a resource constraint setup. We observed that the mean recovery from SPE was 84.1 % and by LLE it was 77.4 % (p value <0.05). Moreover, the average number of metabolites isolated by SPE and LLE was 161.8 ± 18.6 and 140.1 ± 20.4 respectively. The processing cost of LLE was economical. In a cost constraint setting using LLE may be the practical option if used for organic acid analysis. 相似文献
853.
854.
Winston Costa Pereira Muddanna S. Rao D. M. Vasudevan 《Indian journal of clinical biochemistry : IJCB》2003,18(2):161-168
Immunization with a proper dose of an antigenic stimulus leads to cell proliferation and antibody response of circulating
lymphocytes. We have previously observed that Secondary immunized spleenocytes resist ceramide-mediated apoptosisin vitro. Our present study is aimed at investigating thein vivo effect of immunization on apoptosis. Mice were subjected to either Primary or Secondary dose with Tetanus Toxoid. Unimmunized
spleenocytes served as controls. Unimmunized, Primary and Secondary immunized mice were later exposed to chemotherapeutic
drugs such as Etoposide/Methotrexate/Vincristine to induce apoptosis. Apoptosis was studied by using the Feulgen reaction
on 5μ thin parafin sections of spleen. It was observed that Secondary immunized mice showed a lower percentage of apoptosis
as compared to Primary or Unimmunized mice that was subjected to either of the chemotherapeutic drugs. It was thus concluded
that Secondary immunization inhibits the process of chemotherapeutic drug induced apoptosis in vivo. 相似文献
855.
C.S. Badue R. Baeza-Yates B. Ribeiro-Neto A. Ziviani N. Ziviani 《Information processing & management》2007
The performance of parallel query processing in a cluster of index servers is crucial for modern web search systems. In such a scenario, the response time basically depends on the execution time of the slowest server to generate a partial ranked answer. Previous approaches investigate performance issues in this context using simulation, analytical modeling, experimentation, or a combination of them. Nevertheless, these approaches simply assume balanced execution times among homogeneous servers (by uniformly distributing the document collection among them, for instance)—a scenario that we did not observe in our experimentation. On the contrary, we found that even with a balanced distribution of the document collection among index servers, correlations between the frequency of a term in the query log and the size of its corresponding inverted list lead to imbalances in query execution times at these same servers, because these correlations affect disk caching behavior. Further, the relative sizes of the main memory at each server (with regard to disk space usage) and the number of servers participating in the parallel query processing also affect imbalance of local query execution times. These are relevant findings that have not been reported before and that, we understand, are of interest to the research community. 相似文献
856.
Sameer Hinduja 《Ethics and Information Technology》2007,9(3):187-204
Accompanying the explosive growth of information technology is the increasing frequency of antisocial and criminal behavior
on the Internet. Online software piracy is one such behavior, and this study approaches the phenomenon through the theoretical
framework of neutralization theory. The suitability and applicability of nine techniques of neutralization in determining
the act is tested via logistic regression analyses on cross-sectional data collected from a sample of university students
in the United States. Generally speaking, neutralization was found to be weakly related to experience with online software
piracy; other elements which appear more salient are suggested and discussed in conclusion. 相似文献
857.
We present a new paradigm for the automatic creation of document headlines that is based on direct transformation of relevant textual information into well-formed textual output. Starting from an input document, we automatically create compact representations of weighted finite sets of strings, called WIDL-expressions, which encode the most important topics in the document. A generic natural language generation engine performs the headline generation task, driven by both statistical knowledge encapsulated in WIDL-expressions (representing topic biases induced by the input document) and statistical knowledge encapsulated in language models (representing biases induced by the target language). Our evaluation shows similar performance in quality with a state-of-the-art, extractive approach to headline generation, and significant improvements in quality over previously proposed solutions to abstractive headline generation. 相似文献
858.
R. Padma Sree 《Journal of The Franklin Institute》2006,343(2):152-160
The method of identifying first order plus time delay transfer function model proposed for unstable systems by Ananth and Chidambaram [Closed loop identification to transfer function model for unstable systems, J. Franklin Inst. 336 (1999) 1055-1061] is modified to avoid the stability problems [Cheres, Parameter estimation of an unstable system with a PID controller in a closed loop configuration, J. Franklin Inst., 2005, accepted for publication] of the method. Two modifications are proposed. In the first modification of the method, the under-determined algebraic equations problem is converted into an optimization problem for calculation of the three parameters of the first order plus time delay (FOPTD) model. A simple method is given for the initial guess values of the model parameters. In the second approach, from the definition of Laplace transform of the output response, a third equation is formulated. The resulted three equations, in terms of the three parameters of the transfer function model, are then numerically solved. Simulation results are given for the second order plus time delay transfer function considered by Cheres 2005 [Parameter estimation of an unstable system with a PID controller in a closed loop configuration, J. Franklin Inst., 2005, accepted for publication]. The responses of the identified models with the same PID controllers are compared with that of the actual system. PID controllers are designed based on the identified models. The closed loop responses of the controllers on the original system are evaluated and compared. The present methods give better control performances. 相似文献
859.
供应链上下游企业合作研发模式选择--宝钢-大众激光拼焊项目案例分析 总被引:8,自引:0,他引:8
企业供应链的发展促使企业合作研发寻求新的模式。分析了上下游大型企业进行合作研发的诱因及其模式选择问题,结合宝钢一上海大众激光拼焊案例,重点讨论了建立股权制合作研发对上下游企业的影响和供应链创新的意义。 相似文献
860.
Diego Reforgiato Recupero 《Information Retrieval》2007,10(6):563-579
Text document clustering provides an effective and intuitive navigation mechanism to organize a large amount of retrieval
results by grouping documents in a small number of meaningful classes. Many well-known methods of text clustering make use
of a long list of words as vector space which is often unsatisfactory for a couple of reasons: first, it keeps the dimensionality
of the data very high, and second, it ignores important relationships between terms like synonyms or antonyms. Our unsupervised
method solves both problems by using ANNIE and WordNet lexical categories and WordNet ontology in order to create a well structured
document vector space whose low dimensionality allows common clustering algorithms to perform well. For the clustering step
we have chosen the bisecting k-means and the Multipole tree, a modified version of the Antipole tree data structure for, respectively, their accuracy and
speed.
相似文献
Diego Reforgiato RecuperoEmail: |