The paraoxonase 1, 2 and 3 in humans

The paraoxonase gene family in humans includes three members: PON1, PON2 and PON3. The products of those three genes are the following enzymes: paraoxonase 1 (PON1), paraoxonase 2 (PON2) and paraoxonase 3 (PON3). PON1 is mainly associated with a high density lipoprotein (HDL). A small amount of this enzyme is also bound to very low-density lipoprotein (VLDL) and postprandial chylomicrons. PON1 possess organophosphatase, arylesterase and lactonase activity and it hydrolyzes many different substrates. It is also known that PON1 may have antiatherogenic function. Compared to the PON1, PON2 and PON3 are much less studied and described. PON2 is ubiquitously expressed intracellular protein, while PON3 is bound to HDL, like PON1. The both enzymes possess antioxidant properties.     

Superior oxygen and glucose supply in perfusion cell cultures compared to static cell cultures demonstrated by simulations using the finite element method

Oxygen and glucose supply is one of the important factors for the growth and viability of the cells in cultivation of tissues, e.g., spheroid, multilayered cells, and three-dimensional tissue construct. In this study, we used finite element methods to simulate the flow profile as well as oxygen and glucose supply to the multilayered cells in a microwell array chip for static and perfusion cultures. The simulation results indicated that oxygen supply is more crucial than glucose supply in both static and perfusion cultures, and that the oxygen supply through the wall of the perfusion culture chip is important in perfusion cultures. Glucose concentrations decline with time in static cultures, whereas they can be maintained at a constant level over time in perfusion cultures. The simulation of perfusion cultures indicated that the important parameters for glucose supply are the flow rate of the perfusion medium and the length of the cell culture chamber. In a perfusion culture chip made of oxygen-permeable materials, e.g., polydimethylsiloxane, oxygen is hardly supplied via the perfusion medium, but mainly supplied through the walls of the perfusion culture chip. The simulation of perfusion cultures indicated that the important parameters for oxygen supply are the thickness of the flow channel and the oxygen permeability of the walls of the channel, i.e., the type of material and the thickness of the wall.     

大型运输机特种工艺质量控制体系构建与实施

大型运输机由多家机体承制商共同参与研制生产,其中涉及到许多特种工艺项目。而各机体承制商由于硬件设施、组织结构和管理机制不同等原因造成了特种工艺控制方式和方法各自迥异,会对特种工艺过程运行质量和产品交付质量造成潜在威胁。本文运用管理体系理论方法,通过构建与实施某型机特种工艺质量控制体系,统筹规范某型机整体特种工艺质量控制工作,保证了产品交付质量的一致性与可靠性。     

徕卡全站仪与计算机的通讯与数据交换

介绍了有关徕卡全站仪的数据结构、全站仪与PC的数据通讯原理及编程实现方法。并基于徕卡"OSW"—开放的测量世界的理念,使用超级终端,使用VB编程,GeoCOM在线控制实现数据通讯以及徕卡测量办公室(Leica Servey Office)实现全站仪与PC数据交换的方法。     

毛泽东诗论导向中国现当代诗坛

对于新文化运动以来的新诗与旧诗之争,毛泽东曾明确提出：“诗当然应以新诗为主体,旧诗可以写一些,但是不宜在青年中提倡,因为这种体裁束缚思想,又不易学。”这就给新旧体诗对立的局面划上了句号,对当代诗歌的发展具有导向作用。     

我的韩国母亲

我很爱我的母亲,哪怕她会在我热泪汪汪时,强迫我给远亲们打电话,拨出号码并把听筒按在我的脸颊上,在这个时候,我仍然爱着她。她总是爱发威。有一次在杂货店里,她竟然一把将我丢到地上,以此警告我别没大没小。她是我的最爱,也让我抓狂。她真的有点\"奇葩\"。你会觉得让她吃商店里买的点心就像要了她的命似的。她在韩国长大,周围都是韩国人,后来嫁了个韩国人,接着在35岁左右搬到了香     

高职法律基础课教学改革初探

高等职业教育在我国高等教育体系中仍属于新生事物，其课程设置、教学目标、教学内容、教学方法以及对学生的测评等方面都值得认真研究、深入探讨。本文仅就高职教育法律基础课的教学改革谈一点粗浅的认识。     

Are we using Thyroid Function Tests Appropriately?

Thyroid function tests are very important for the diagnosis and monitoring of patients with thyroid dysfunction. The guidelines recommend serum thyroid stimulating hormone (TSH) as the single most reliable test to diagnose all common forms of hypothyroidism and hyperthyroidism. The aim of this study was to analyze the ordering pattern for thyroid function tests by physicians and the analysis of results based on the clinical history. The mean age of the patients was 32.5 ± 6.5 years. Majority of samples (87.7% of total) were received from the departments of Medicine and Gynae. Thyroid profiles (47.5%) were ordered more frequently as compared to TSH only (46%). There was no significant difference in the percentage of normal reports for both types of tests. 77.8% of TFT and 76.6% of TSH samples had results within the reference range. The percentage of abnormal results was 13.7% in the patients who were screened for thyroid disorders. There is a need to redefine the case definition for thyroid dysfunction and order the appropriate test in a rational and cost effective manner.