Antipsychotics-induced hyperprolactinemia and screening for macroprolactin

IntroductionHigh prolactin (PRL) concentrations are found in laboratory test results of patients on majority of antipsychotic drugs. Prevalence rates and degrees of severity of hyperprolactinemia (HPRL) based on PRL concentration may depend on the presence of macroprolactin in the serum. The aim of the study was to investigate the difference between PRL concentrations before and after precipitation of macroprolactin and to examine if there were any changes in the categorization of HPRL between samples prior and after precipitation.Materials and methodsTotal of 98 female patients (median age 33; range 19-47 years) diagnosed with a psychotic disorder, proscribed antipsychotic drugs, and with HPRL were included. Total PRL concentration and PRL concentration after macroprolactin precipitation with polyethylene glycol (postPEG-PRL) were determined by the chemiluminometric method on the Beckman Coulter Access2 analyser.ResultsTotal PRL concentrations (median 1471; IQC: 1064-2016 mlU/L) and postPEG-PRL concentrations (median 1453; IQC: 979-1955 mlU/L) were significantly correlated using intraclass correlation coefficient for single measurements (mean estimation 0.96; 95%CI 0.93-0.97) and average measurement (mean estimation 0.98; 95%CI 0.96-0.99), and all investigated female patient had HPRL according to PRL and postPEG-PRL concentration. The median PRL recovery following PEG precipitation was 95; IQC: 90-100%. There was substantial agreement (kappa test = 0.859, 95% CI: 0.764-0.953) between the categories of HPRL severity based on total PRL concentrations and postPEG-PRL concentrations.ConclusionThe study demonstrated that HPRL was present in all subjects using the reference interval for total PRL concentration and postPEG-PRL concentration with no significant impact of macroprolactin presence in the serum on the categorization of patients according to severity of HPRL.     

Teachers’ attitudes towards tracking: testing the socialization hypothesis

The paper examines how teachers’ attitudes towards tracking (separating pupils into groups with different curricula on the basis of their abilities and results) differ among various generations of teachers. Fundamental and quick changes in the educational system occurred in the Czech Republic after the Velvet Revolution in 1989 as a unified educational system moved to a system strongly accenting tracking practices. We use this ‘policy discontinuity’ to validate teacher socialization theory and test three alternative socialization hypotheses based on different key periods in teachers’ development: the pupil experience hypothesis, the pedagogical preparation hypothesis and the pedagogical experience hypothesis. We work with a data-set from 2009 covering 1002 Czech teachers. The mean tests and the logistic regression analysis support the socialization theory, however only the pedagogical experience hypothesis was found to be most influential.     

Agency and structure in academic development practices: are we liberating academic teachers or are we part of a machinery supressing them?

This text taps into an ongoing discussion about academic development. It challenges an image of academic development as precarious and liminal and explores academic development as powerful. Sources of power are described and put into the context of values, ideologies, and policies governing higher education of today. It is our hope that readers will be inspired to problematise their own academic development practices and to reclaim a phase in the history of the profession where members displayed more of a political awareness.     

Understanding and influencing teaching and learning cultures at university: a network approach

Academic cultures might be perceived as conservative, at least in terms of development of teaching and learning. Through a lens of network theory this conceptual article analyses the pattern of pathways in which culture is constructed through negotiation of meaning. The perspective contributes to an understanding of culture construction and maintenance with a potential to aid academic developers and others in the endeavour to influence teaching and learning cultures in academia. Throughout the discussion the importance of supporting the weak links between clusters of individuals stands out as a feature to focus upon. We propose that the sheer complexity of culture construction and maintenance in academic organisations is likely to cause any single, isolated attempt for change to fail Instead, we argue that a multitude of inter-related initiatives over a long period of time is likely to distinguish strategies that are successful in influencing academic teaching and learning cultures.     

Entrepreneurialism at the University of Zagreb: Managing the Sustainability of Change

This article presents a study of the different aspects of entrepreneurialism at the University of Zagreb in the context of Croatian higher education. The recent history of changes at the University of Zagreb is described using a temporal perspective from the beginning of the development of the European Higher Education Area to the implementation of the Bologna Process in Croatia. The theoretical framework for the study has been Burton Clark's (1998 Clark, B. R. 1998. Creating Entrepreneurial Universities, Oxford: Pergamont and Elsevier Science. Organizational Pathways of Transformation [Google Scholar]) seminal analysis of the main features of academic entrepreneurialism. Each feature: the strengthening of steering capacity, the diversification of financial sources, a stimulated academic heartland, an extended periphery, and integrating entrepreneurial culture have been elaborated using the illustrative examples from university practice and university statistics. The last part of the study gives an overview of the results of the empirical study conducted among university managers, teachers, and students on their perceptions of the university's entrepreneurial culture at the level of the institution as a whole as well as at the level of their respective faculty. In the final conclusions, the main requirements for effective change management within the university context are listed.     

Approximation based on orthogonal and almost orthogonal functions

In this paper, we define a class of almost orthogonal rational functions of Legendre type in a new manner. Relations of these functions with classical exponentional functions orthogonal over interval (0, ∞), as well as classical polynomials orthogonal over (0, 1) are explained. Defining relations of these functions can be used for designing almost orthogonal filters. These filters are generators of orthogonal signals and can be successfully applied in finding the best signal approximation in the sense of the mean square error. The filters orthogonal property enables building of physical (in this case electrical) models of dynamical systems (the sources of signals to be approximated) either with less components for the same model accuracy or higher accuracy for the same number of components than the other known models. New filters represent further improvement of previously designed filters, by the same authors, in the sense of simplicity, higher accuracy, lesser approximation time and even a possibility to approximate signals generated by systems with built-in imperfections. Series of experiments were performed to analyze the dependence of approximation accuracy and the number of filters sections.     

WSVR-based fuzzy neural network with annealing robust algorithm for system identification

This paper proposes a fuzzy neural network (FNN) based on wavelet support vector regression (WSVR) approach for system identification, in which an annealing robust learning algorithm (ARLA) is adopted to adjust the parameters of the WSVR-based FNN (WSVR-FNN). In the WSVR-FNN, first, the WSVR method with a wavelet kernel function is used to determine the number of fuzzy rules and the initial parameters of FNN. After initialization, the adjustment for the parameters of FNNs is performed by the ARLA. Combining the self-learning ability of neural networks, the compact support of wavelet functions, the adaptive ability of fuzzy logic, and the robust learning capability of ARLA, the proposed FNN has the superiority among the several existed FNNs. To demonstrate the performance of the WSVR-FNN, two nonlinear dynamic plants and a chaotic system taken from the extant literature are considered to illustrate the system identification. From the simulation results, it shows that the proposed WSVR-FNN has the superiority over several presented FNNs even the number of training parameters is considerably small.     

The effect of inspiratory muscle fatigue on acid-base status and performance during race-paced middle-distance swimming

The aim of this study was to investigate the effect of pre-induced inspiratory muscle fatigue (IMF) on race-paced swimming and acid-base status. Twenty-one collegiate swimmers performed two discontinuous 400-m race-paced swims on separate days, with (IMF trial) and without (control trial) pre-induced IMF. Swimming characteristics, inspiratory and expiratory mouth pressures, and blood parameters were recorded. IMF and expiratory muscle fatigue (P < 0.05) were evident after both trials and swimming time was slower (P < 0.05) from 150-m following IMF inducement. Pre-induced IMF increased pH before the swim (P < 0.01) and reduced bicarbonate (P < 0.05) and the pressure of carbon dioxide (PCO₂) (P < 0.05). pH (P < 0.05), bicarbonate (P < 0.01) and PCO₂ (P < 0.05) were lower during swimming in the IMF trial. Blood lactate was similar before both trials (P > 0.05) but was higher (P < 0.01) in the IMF trial after swimming. Pre-induced IMF induced respiratory alkalosis, reduced bicarbonate buffering capacity and slowed swimming speed. Pre-induced and propulsion-induced IMF reflected metabolic acidosis arising from dual role breathing and propulsion muscle fatigue.     

Designing a business model for financial products for cultural heritage in the Korean market

There are many contingent valuation (CV) studies to estimate the economic benefits of cultural heritage, but few provided advice on the design of financial products for cultural heritage assets. This paper conducted conjoint and willingness-to-pay (WTP) analyses for providing the design implication of these financial products. We calculated WTP for each attribute. The result of conjoint analysis shows that people prefer a short period of investment, high-expected rate of return and small amount of money invested. Only the amount invested and the rate of return on investment are significant to estimate WTP for these financial products.