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141.
Four reasons for the prevalent delays in resolving debates in the social sciences are discussed. These are the difficulty in clearly answering certain questions for investigation, the inadequacy of common research designs for establishing “firm inferences,”; the lack of methods for reviewing and synthesizing disparate results from different studies of the same topic, and the inappropriateness of present debate arenas for expediting resolution. Some characteristics of the arenas of social science debates are described, and several suggestions for improving these arenas are proposed.  相似文献   
142.
In this qualitative study, the authors examined master's‐level counselor trainees' reactions to difficult dialogues in the classroom regarding racism, heterosexism/homophobia, and ableism over a 3‐year period. Using the Consensual Qualitative Research method as introduced by C. E. Hill, B. J. Thompson, and E. N. Williams (1997), the data analysis team analyzed narrative and reaction papers submitted during a didactic course on multiculturalism. Behavioral reactions were identified that form the basis for this study: denial, deflection, rationalization, intellectualization, principium, false envy, minimization, and benevolence.  相似文献   
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Discrimination between a tone + light compound and its components in positive and negative patterning schedules was examined. In the positive schedule, reinforced compound presentations (C+) were intermixed with unreinforced component presentations (T?, L?). In the negative schedule, the compound was unreinforced (C?) and the components were reinforced (T+, L+). In Experiment 1, appetitive conditioning of rats’ anticipatory magazine responses was used, and in Experiment 2, aversive conditioning of the rabbit’s nictitating membrane response was used. Both experiments revealed that the positive patterning schedule consistently produced rapid acquisition of appropriate discriminative responding. The results of the negative patterning schedule were more complex. Specifically, the results of Experiment 1 demonstrated that naive rats initially showed rapid acquisition of the negative patterning discrimination. However, schedule reversals revealed that experience with the positive patterning schedule virtually abolished subsequent acquisition of discriminative responding under the negative patterning schedule. The results of Experiment 2 revealed that naive rabbits showed very slow acquisition of discriminative responding under the negative patterning schedule. The results are discussed in relation to the unique-stimulus hypothesis, a contextual encoding hypothesis, and a configural hypothesis.  相似文献   
145.
低氧诱导因子与乳腺癌转移   总被引:2,自引:0,他引:2  
概肿瘤,特别是实体瘤,其内部微环境处于一种低氧或缺氧的状态,肿瘤的这种低氧微环境将诱导活化低氧诱导因子(HIF-1)信号通路。HIF-1信号通路在乳腺癌的转移中发挥着重要的作用。乳腺癌的转移涉及肿瘤细胞的浸润、进入血管、通过血液循环迁移、到达远端毛细血管内壁、穿透血管壁进入新的器官以及在新的部位形成转移灶等步骤,过程非常复杂。本文重点围绕 HIF-1在转移各个步骤中的作用进行综述。  相似文献   
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The aims of the study were: to identify the number of SENCOs who have received specific training on sensory integration. To determine the understanding of the eight senses and sensory integration theory and sensory strategies. Determine any common gaps in knowledge or misconceptions. Fifty-five surveys were completed. 40% of respondents had received training on sensory processing. There was a significant chi-squared correlation between those that had received training and those that stated they did not know or made guesses about what the vestibular and proprioceptive senses are important for. There was a correlation between those that had received training and those that had good knowledge of the signs of sensory hyper-responsivity. There was no statistical significance of increased knowledge on sensory hypo-responsivity between those who had and had not received training. SENCOs who rated their school as being sensory-friendly had a greater understanding of what sensory integration is important for. Pertinently, those who rated their school as being ‘sensory-friendly’ (45.5%) were 8.5 times more likely to know sensory integration is needed for self-regulation. A number of recommendations are made including the need for greater collaboration between therapists and teachers to increase understanding of sensory integration and the impact of this on a child's education and wellbeing at school. Sensory strategy programmes are to be written with teaching staff and not given by the therapist in an ‘expert’ role. Sensory integration awareness training, including why and how to utilise sensory strategies, is to be encompassed in the SENCO national qualification.  相似文献   
148.
The importance of reducing restraint and restrictive interventions in special schools has been recognised across the four nations of the UK. Government guidance for England and Wales, and recommendations produced by Restraint Reduction Scotland, both reference Positive behavioural support (PBS) as an evidence-based approach that can be used to proactively support pupils with, or at risk of, behaviours that challenge. The Department of Education of Northern Ireland recommends the development of behaviour support plans to support children with special education needs and disabilities. Special schools, however, also have a responsibility to set high expectations for every pupil, to provide access to the respective national curricula and to meet individual needs. School-wide positive behavioural support (SW-PBS), originated in the USA in the 1990s in response to a body of evidence that showed improved social and academic outcomes when behavioural interventions were implemented across whole school settings. It is increasingly being adopted in the UK. Drawing upon examples from schools in England and Wales with which the authors are familiar, this paper outlines the rationale for a special schools' model of SW-PBS and illustrates the ways in which this can be adjusted to meet the specific needs of each setting.

Key Points

  • Reducing restraint and restrictive interventions in schools is a high priority across all four nations of the UK.
  • Special schools also have a responsibility to provide children with special education needs and disabilities positive learning environments that maximise learning opportunities and meet individual needs.
  • School-wide positive behaviour support (SW-PBS) provides a useful framework to help special schools meet these expectations.
  相似文献   
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