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521.
Suchitra Kumari Tarun Kumar Panda Tapaswini Pradhan 《Indian journal of clinical biochemistry : IJCB》2017,32(2):134-141
The mechanical properties of extracellular matrix (ECM) and connective tissues is largely dependent on the collagen and elastin structure. Lysyl oxidase (LOX) plays a critical role in the formation and repair of the ECM by oxidizing lysine residues in elastin and collagen, thereby initiating the formation of covalent cross linkages which stabilize these fibrous proteins. Due to its multiple functions both extracellularly and intracellularly, lysyl oxidase is involved in several processes in the tumorigenic pathway, in many different cancer types and stages. Alteration in LOX activity is implicated in many diseases and disorders including inflammation and inflammatory diseases, fibrosis of distinct organs and fibrotic disorders, cancer promotion and progression. There are only sparse reports of mutations or epigenetic alterations in the LOX gene. This review provides the recent clinical developments in the molecular mechanisms and pathologic process, pointing out LOX as a potential therapeutic target in translational medicine. 相似文献
522.
Rakesh D. Raut Bhaskar B. Gardas Manoj Kumar Jha Pragati Priyadarshinee 《The Journal of High Technology Management Research》2017,28(2):125-141
For cutting down cost and improving the efficiency of enterprises, adoption of innovations in ICT especially in cloud computing applications is the need of the time in the highly competitive global environment. It has been noted that generally, the Indian MSMEs are not utilizing the CC applications for the promotion of their business activities and are not availing their benefits. Hence, in the present investigation, the critical success factors (CSFs) for cloud computing adoption (CCA) in the Indian micro, small and medium enterprises (MSMEs) are identified through an exhaustive literature review and expert opinions. The association between the identified factors is established by employing an interpretive structural modeling methodology that is a multi-criteria decision making (MCDM) approach. Later, the MICMAC analysis is carried out for identifying the factors having high influential power. The results of the study revealed that a CSF namely ‘previous technological experience’ is the most significant factor having the highest driving power. The findings of this research are intended to guide cloud service providers, enterprise managers, and governmental bodies in formulating the strategies and policies for effective implementation of cloud computing facilities and harness the benefits of the same. This study makes a significant contribution to the knowledge base of CC adoption for future research in the subject field. 相似文献
523.
Medically diagnosed alcoholics can be differentiated reliably from non-alcoholics using clinically laboratory tests. In the
present study, patients with liver diseases either due to alcohol or without alcohol compared with a group of normal healthy
persons. Heavy drinkers showed significantly lower body weight and percent body fat, and low BMI compared with other groups.
The percentage of hemoglobin and total number of RBC were found to be significantly decreased, whereas mean corpuscular volume
(MCV) significantly increased in alcoholic liver disease (ALD). Hyperbilirubinemia, hyperuricemia and hypoalbuminemia correlate
with alcohol intake. Albumin/globulin ratio significantly decreased in ALD. In acute liver injury AST/ALT ratio is ≤1.0, whereas
in alcoholic hepatitis it is always >1.0. Moderately elevated level of ALP and high GGT values are good discriminator of alcoholic
patients. Alcohol-induced liver injury is linked to oxidative stress as observed by decreased level of reduced glutathione
and ascorbic acid, and increased level of thiobarbituric acid reactive substances. 相似文献
524.
P. K. Nigam V. S. Narain Ajay Kumar 《Indian journal of clinical biochemistry : IJCB》2006,21(1):54-61
Sialic acid, the acylated derivatives of 9-carbon sugar neuraminic acid, present as terminal component of oligosaccharide
chains of many glycoproteins and glycolipids, has been recognized to be involved in the regulation of a great variety of biological
phenomena. Studies have shown that serum sialic acid predicts both coronary heart disease and stroke mortality and reflects
the existence or activity of an atherosclerotic process. Most of the studies have shown an elevation in serum sialic acid
concentration in coronary heart disease and a positive correlation between the raised serum sialic acid and the severity of
the coronary lesions is observed. However, a few contradictory reports are also available. Racial differences in serum sialic
acid have also been reported and correlated with international differences in the prevalence of atherosclerosis. Reduced sialic
acid content of platelets, erythrocytes and lipoproteins may play important role in the pathogenesis of atherosclerosis. Elucidation
of the mechanism of alternation in sialic acid concentration may throw more light on its potential clinical utility. Hence
more studies are needed to designates sialic acid as a cardiovascular risk factor/marker. 相似文献
525.
Praveen Kumar Shetty T. N. Pattabiraman 《Indian journal of clinical biochemistry : IJCB》2004,19(1):97-101
The present study deals with the estimation of total carbohydrate, protein bound carbohydrate, bound fucose and sialic acid
along with total protein in disease conditions like gingivitis, periodontitis and their comparison with the normals.
The neutral hexose values in gingivitis (8.08±2.20mg/100mg protein) and periodontitis (12.5±2.16mg/ 100mg protein) decreased
significantly when expressed per 100 mg protein compared to normals (19.8±1.89mg/100mg protein). This might be because of
higher protein concentration in these two clinical conditions. The ethanol insoluble hexose values were significantly reduced
in both these conditions compared to controls (3.71±1.64,5.91±1.63,7.65±0.86mg/100mg protein respectively). The ethanol soluble
hexose values were also found to be drastically reduced. This decrease in saliva appears to be characteristic feature of oral
diseases. In gingivitis and periodontitis fucose level was found to be increased compared to normals when expressed as a function
of salivary volume. However in terms of protein concentration the values in gingivitis (2.95±1.59), periodontitis (3.26±0.98)
and normals (3.20±0.50mg/100mg) were not different. Sialic acid in ethanol insoluble fraction of salivary samples mg/100mg
protein was found to be significantly reduced in both gingivitis (0.78±0.33) and periodontitis (0.95±0.31) compared to controls
(1.92±0.33) 相似文献
526.
S. V. Suresh Babu M. M. Shareef A. Pavan Kumar Shetty K. Taranath Shetty 《Indian journal of clinical biochemistry : IJCB》2002,17(2):7-26
Quantification of total and individual amino acids in biological fluids such as plasma, urine and cerebrospinal fluid has
an important diagnostic implication in laboratory medicine. The present paper describes protocols for the assay of total amino
acids by modified method based on dinitrophenyl and HPLC profile involving pre-column derivatization with o-pthalaldehyde
(OPA) derivatization, respectively. The method, based on the alkylation of-SH groups prior to OPA derivatization of amino
acids followed by reverse phase high performance liquid chromatography, provide a comprehensive profile of more than twenty
amino acids (including-SH group containing) in a single run lasting about 45 minutes. The present study, apart from establishing
the normal profile of amino acids in plasma of Indian sub population, also presents HPLC profile for some of the rare amino
acidopathies. 相似文献
527.
Biochemical activity of selenium and glutathione on country made liquor (CML) induced hepatic damage in rats 总被引:1,自引:0,他引:1
G. Kumar G. Sharmila Banu M. Rajasekara Pandian 《Indian journal of clinical biochemistry : IJCB》2007,22(1):105-108
The serum and hepatic enzymes of rats were studied after exposed to country made liquor (CML) along with two chelating agents
(glutathione and Selenium). There was a significant increase in several serum enzyme levels (viz., aspartate transaminase,
alanine transaminase, alkaline phosphatase, sorbitol dehydrogenase, glutamate dehydrogenase, bilirubin) and decrease in various
hepatic enzymes (Succinic dehydrogenase, Glucose 6-phosphatase, 5'Nucleotiease, Acid phosphatase, Acid ribonuclease, Cytochrome
P-450) due to repeated administration of CML (2ml/100g of body weight). Results of this study revealed that the GSH and Se
could give a significant protective action in serum and hepatic enzymes of CML exposed rats. 相似文献
528.
Disparities in health and healthcare are a major concern in the United States and worldwide. Approaches to alleviate these disparities must be multifaceted and should include initiatives that touch upon the diverse areas that influence the healthcare system. Developing a strong biomedical workforce with an awareness of the issues concerning health disparities is crucial for addressing this issue. Establishing undergraduate health disparities courses that are accessible to undergraduate students in the life sciences is necessary to increase students’ understanding and awareness of these issues and motivate them to address these disparities during their careers. The majority of universities do not include courses related to health disparities in their curricula, and only a few universities manage them from their life sciences departments. The figures are especially low for minority-serving institutions, which serve students from communities disproportionally affected by health disparities. Universities should consider several possible approaches to infuse their undergraduate curricula with health disparities courses or activities. Eliminating health disparities will require efforts from diverse stakeholders. Undergraduate institutions can play an important role in developing an aware biomedical workforce and helping to close the gap in health outcomes. 相似文献
529.
Mirna E. Turcios Naresh Kumar Agarwal Linda Watkins 《The Journal of Academic Librarianship》2014,40(5):473-479
There is an extensive amount of Library and Information Science (LIS) writing produced each year. While there is general awareness regarding the variety of journal literature, there is no certainty on the percentage of the collection that we can call research. This project is an important first step in answering the question. A content analysis of the LIS academic/scholarly journals at the Simmons College Library was conducted. The research level collection of LIS literature makes the library an ideal candidate for this study. The latest issue of each journal subscribed to for fiscal year 2012–2013 containing academic/scholarly content was analyzed. Each article was analyzed to determine: 1) if it was research or non-research, 2) the method used to collect data for the study in the article, and 3) the subject terms or keywords associated with the article. 105 journal titles were identified out of 177 periodicals. In the 1880 articles analyzed from these, 16% qualified as research. Surveys were found to be the most popular research method used. This study will benefit students, faculty, and staff with research requirements as well as librarians who guide patrons through a search for research literature. 相似文献
530.
Sheng-chun DANG Yan-hua ZENG Ping-jiang WANG Bao-ding CHEN Rong-fang CHEN Arun KUMAR SINGH Pankaj KUMAR Shu FENG Lei CUI Hao WANG Jian-xin ZHANG 《Journal of Zhejiang University. Science. B》2014,15(6):556-565