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61.
This case study illustrates instruction in an urban 6th‐grade classroom in which students were learning about mass, volume, and density by attempting to layer (stack) three miscible solutions with differing densities atop one another. The study examines classroom discourse and interaction on the basis of four teaching goals: (a) reaching consensus about which stacks were possible, (b) developing persuasive arguments that separated data from noise, (c) establishing social norms for collective inquiry, and (d) appreciating the epistemological status of scientific knowledge. The study traces the fate of three stacks that students claimed were possible after initial investigations with the solutions. These claims underwent a process of collective validation in which consensus without coercion was the goal, which illustrates emergent standards for backing claims with evidence, as well as for replicability, among the students. Students were successful in achieving three of the four goals, with some qualifications. In relation to Goal 3, which required generalization to other situations, somewhat less success is reported. Limitations in the current standards, difficulties of time allotment in current curricula, and establishing classroom cultures of inquiry are discussed. © 1999 John Wiley & Sons, Inc. J Res Sci Teach 36: 179–199, 1999  相似文献   
62.
The authors examined the effectiveness of a group career counseling model (Pyle, 2007 ) on college students’ career decision‐making abilities. They used a Solomon 4‐group design and found that students who participated in the career counseling groups had significantly greater increases in career decision‐making abilities than those who did not participate in the groups. Implications for counseling and future research are discussed.  相似文献   
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Thermotaxis has been demonstrated to be an important criterion for sperm evaluation, yet clinical assessment of thermotaxis capacity is currently lacking. In this article, the on-chip thermotaxis evaluation of human sperm is presented for the first time using an interfacial valve-facilitated microfluidic device. The temperature gradient was established and accurately controlled by an external temperature gradient control system. The temperature gradient responsive sperm population was enriched into one of the branch channels with higher temperature setting and the non-responsive ones were evenly distributed into the two branch channels. We employed air-liquid interfacial valves to ensure stable isolation of the two branches, facilitating convenient manipulation of the entrapped sperm. With this device, thermotactic responses were observed in 5.7%-10.6% of the motile sperm moving through four temperature ranges (34.0-35.3 °C, 35.0-36.3 °C, 36.0-37.3 °C, and 37.0-38.3 °C, respectively). In conclusion, we have developed a new method for high throughput clinical evaluation of sperm thermotaxis and this method may allow other researchers to derive better IVF procedure.  相似文献   
64.
Bioluminescence resonance energy transfer (BRET) is a form of Förster resonance energy transfer. BRET has been shown to support lower limits of detection than fluorescence resonance energy transfer (FRET) but, unlike FRET, has not been widely implemented on microfluidic devices for bioanalytical sensing. We recently reported a microscope-based microfluidic system for BRET-based biosensing, using a hybrid, high quantum-efficiency, form of BRET chemistry. This paper reports the first optical fiber-based system for BRET detection on a microfluidic chip, capable of quantifying photon emissions from the low quantum-efficiency BRET2 system. We investigated the effects of varying core diameter and numerical aperture of optical fibers, as well as varying microfluidic channel design and measurement conditions. We optimized the set-up in order to maximize photon counts and minimize the response time. The optimized conditions supported measurement of thrombin activity, with a limit of detection of 20 pM, which is lower than the microscope-based system and more than 20 times lower than concentrations reported to occur in plasma clots.  相似文献   
65.
Peer assessment is very various in its implementation. Six studies of peer assessment are reviewed, four of them in higher education. A literature review is followed by five empirical studies. Strengths and weaknesses of each study are considered and issues are raised. Variables in peer assessment needing further exploration are extricated – in sample definition, specification of type of peer assessment, organisational nature of the intervention, and the measures which are used to evaluate change. It is suggested that further experimental and quasi-experimental studies are necessary to contrast one or two of these variables at a time.  相似文献   
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The aim of this study was to examine strategies for selecting a criterion value during anthropometric data assembly and their resilience to imposed error. Sixty-seven women aged 16-60 years were subjected to three separate series of measurements, which included six skinfolds and three girths. A random error term was added to the first of the three series of measurements to produce a pseudo-series containing error, termed the 'erroneous replicated series'. Five strategies were then used to determine the criterion value of each of the replication series: the first measurement, the mean of the first two measurements, the mean of all three measurements, the mean of the closest two measurements and the median of the three measurements. The technical error between the criterion values of the true and the flawed replication series for each of the selection strategies was calculated. We found that, for five of the skinfolds and all of the girths, the median value provided the smallest technical error of measurement between the criterion values for the true and erroneous replication series. We conclude that the strategy of selecting the median of three measurements is the most resilient to imposed error.  相似文献   
70.
Despite science learning in settings such as science museums being recognized as important and given increasing attention in science education circles, the investigation of parents’ and their children’s metacognition in such settings is still in its infancy. This is despite an individual’s metacognition being acknowledged as an important influence on their learning within and across contexts. This research investigated parents’ metacognitive procedural and conditional knowledge, a key element of their metacognition, related to (a) what they knew about how they and their children thought and learned, and (b) whether this metacognitive knowledge influenced their interactions with their children during their interaction with a moderately complex simulation in a science museum. Parents reported metacognitive procedural and conditional knowledge regarding their own and their children’s thinking and learning processes. Further, parents were aware that this metacognitive knowledge influenced their interactions with their children, seeing this as appropriate pedagogical action for them within the context of the particular exhibit and its task requirements at the science museum, and for the child involved. These findings have implications for exhibit and activity development within science museum settings.  相似文献   
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