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71.
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A Methylome‐Wide Association Study of Trajectories of Oppositional Defiant Behaviors and Biological Overlap With Attention Deficit Hyperactivity Disorder 下载免费PDF全文
Edward D. Barker Esther Walton Charlotte A.M. Cecil Richard Rowe Sara R. Jaffee Barbara Maughan Thomas G. O'Connor Argyris Stringaris Alan J. Meehan Wendy McArdle Caroline L. Relton Tom R. Gaunt 《Child development》2018,89(5):1839-1855
In 671 mother–child (49% male) pairs from an epidemiological birth cohort, we investigated (a) prospective associations between DNA methylation (at birth) and trajectories (ages 7–13) of oppositional defiant disorder (ODD), and the ODD subdimensions of irritable and headstrong; (b) common biological pathways, indexed by DNA methylation, between ODD trajectories and attention deficit hyperactivity disorder (ADHD); (c) genetic influence on DNA methylation; and (d) prenatal risk exposure associations. Methylome‐wide significant associations were identified for the ODD and headstrong, but not for irritable. Overlap analysis indicated biological correlates between ODD, headstrong, and ADHD. DNA methylation in ODD and headstrong was (to a degree) genetically influenced. DNA methylation associated with prenatal risk exposures of maternal anxiety (headstrong) and cigarette smoking (ODD and headstrong). 相似文献
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ABSTRACT Trustworthiness is key in journalism, yet some journalists intentionally deceive their audiences by fabricating sources or inventing news stories altogether. Earlier research suggests that deceitful news articles have characteristics that are different from trustworthy news articles. We aimed to confirm and expand on the existing literature by examining the case of Perdiep Ramesar, an esteemed Dutch journalist until it was discovered in 2014 that sources were non-existing in 126 of his articles for national newspaper Trouw (“Fidelity”). Using content analysis, we searched for systematic differences in source use and presentation comparing Ramesar’s deceptive news articles with two same-sized sets of reliable articles, (1) articles on similar topics from other journalists and (2) articles with verifiable sources from Ramesar himself. Results indicate that compared to real news sources, fictitious sources are more often secondary definers, who are presented in more stereotypical ways and through more and longer direct quotations. Furthermore, negations and self-references occur more often in deceptive news articles. 相似文献
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This paper describes an university sponsored, professionally mediated self-help support program for wives of graduate students and staff members and discusses the rationale for its structure. First, we identify the kinds of problems these women have that make it difficult for them to adapt to their new surroundings. We then present the program as it now functions, together with reports on the wives' assessments of different features of the program. In the discussion that follows, we outline the problems of implementing and maintaining this kind of support program and suggest why self-help groups for this constituency need the active involvement of a professional familiar with the details of campus resources and social life. We also address the importance of locating that professional in a strategic place within the organization to be able to act on that knowledge. 相似文献
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German universities built over the years highly specialized book collections for use by faculty and graduate students. The German term, seminarbibliothek, is often applied to these types of collections, although examples can be found in universities across Europe. The purpose of this article is to examine a similar type of collection using ebooks in veterinary science and to compare this collection to the standard subject classified ebook collections. Most collection development in college and university libraries focuses on academic subjects. The type of collection being described here focuses on a mission. A mission-focused collection increases the use of library holdings and greatly benefits the stakeholders within the institution. This study looks at how such a collection might be formed and defined and what possible effects this might have on the use of collections of this type. 相似文献
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Charlotte D. Schneider 《Legal Reference Services Quarterly》2017,36(2):85-102
The Legal Information Institute (LII) has been at the forefront of access to justice for 25 years as the first organization to publish online the United States Code. More than just publishing the law online, the LII has been the leader in helping people find and understand the law since 1992, through innovative technologies they've created or employed for use with their collections and through partnerships with other like-minded organizations, groups, and individuals. Two decades later, the LII was inspired to help more people trying to find and understand the law. This summer will mark the third anniversary of the LII's virtual Reference Desk. 相似文献
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Copper(II) hydroxide (as the rarely occurring mineral spertiniite) is formed under alkaline, oxidising conditions. It has been observed as a naturally occurring corrosion product of brass in sea water. But most occurrences on copper alloys are due to conservation treatments using basic solutions (sodium hydroxide or ammonia) or to intentional patination. Classical brass centrepieces (c. 1800), ‘cleaned’ with ammonia solution, developed a blue spertiniite patina in gaps, where evaporation was hindered. Additional to the danger of stress corrosion cracking this is another reason now outlawing this treatment. Copper pigment layers will transform to copper hydroxide when exposed to bases. The treatment of basic copper salts with bases has been used intentionally in the production of Bremen blue and similar pigments which can be composed of copper hydroxide as well. 相似文献
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Spectrometric handheld light meters that can provide adequate data for evaluation of replacement bulbs for contemporary art objects are now commercially available. This approach was taken to assess potential replacements for the incandescent street lamps in Chris Burden's Urban Light at LACMA, Los Angeles, USA. These meters are also useful tools for monitoring and characterizing museum lighting, which are currently done with illuminance (lux) meters. The new spectral light meters will enable conservators to tailor lighting recommendations for individual artworks, when spectral information from these meters is combined with damage function data on artists’ materials. The latter information can be obtained for some materials by a small modification to the microfade testing procedure, as exemplified by microfading colored samples Henri Matisse created during the design phase for La Gerbe. 相似文献
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