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51.
Emey Suhana Mohd Azamai Suhaniza Sulaiman Shafina Hanim Mohd Habib Mee Lee Looi Srijit Das Nor Aini Abdul Hamid Wan Zurinah Wan Ngah Yasmin Anum Mohd Yusof 《Journal of Zhejiang University. Science. B》2009,10(1):14-21
Chlorella vulgaris (CV) has been reported to have antioxidant and anticancer properties. We evaluated the effect of CV on apoptotic regulator
protein expression in liver cancer-induced rats. Male Wistar rats (200∼250 g) were divided into eight groups: control group
(normal diet), CDE group (choline deficient diet supplemented with ethionine in drinking water to induce hepatocarcinogenesis),
CV groups with three different doses of CV (50, 150, and 300 mg/kg body weight), and CDE groups treated with different doses
of CV (50, 150, and 300 mg/kg body weight). Rats were sacrificed at various weeks and liver tissues were embedded in paraffin
blocks for immunohistochemistry studies. CV, at increasing doses, decreased the expression of anti-apoptotic protein, Bcl-2,
but increased the expression of pro-apoptotic protein, caspase 8, in CDE rats, which was correlated with decreased hepatoctyes
proliferation and increased apoptosis as determined by bromodeoxy-uridine (BrdU) labeling and terminal deoxynucleotidyl transferase
mediated dUTP nick-end labeling (TUNEL) assay, respectively. Our study shows that CV has definite chemopreventive effect by
inducing apoptosis via decreasing the expression of Bcl-2 and increasing the expression of caspase 8 in hepatocarcinogenesis-induced
rats.
Project supported by Department of Biochemistry, Faculty of Medicine, UKM Medical Center, Universiti Kebangsaan Malaysia,
and the Malaysian Ministry of Science and Technological Innovation (MOSTI) 相似文献
52.
INTRODUCTION Biosphere pollution by heavy metals and nu-cleotides was accelerated dramatically during the last few decades due to mining, smelting, manufacturing, treatment of agricultural soils with agro-chemicals and soil sludge, etc. Problems associated with the contamination of soil and water such as animal wel-fare, health, fatalities and disruptions of natural eco-systems are well documented (He et al., 2005). Heavy metals such as Pb, Cr, As, Cu, Cd, and Hg, being added to our so… 相似文献
53.
Florence Martin Lynn Ahlgrim-Delzell Kiran Budhrani 《The American journal of distance education》2017,31(1):3-19
Systematic reviews of literature are studies that strategically search for published research on a specific topic in order to synthesize what is known about the topic. This systematic review describes 157 articles on synchronous online learning (SOL) from thirty-four different countries on instructional setting, content areas, participant demographics, research designs, independent and dependent variables, SOL technologies, and data-collection tools. 相似文献
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Skamp Keith Boyes Eddie Stanisstreet Martin Rodriguez Manuel Malandrakis George Fortner Rosanne Kilinc Ahmet Taylor Neil Choker Kiran Shweta Dua Ambusaidi Abdullah Cheong Irene Kim Mijung Yoon Hye-Gyoung 《Research in Science Education》2021,51(3):861-887
Research in Science Education - Voting for various pro-environmental governmental policies is an indirect, but potentially effective, action that citizens can take to reduce global warming (GW) and... 相似文献
57.
INTRODUCTION With the enormous progress in tumor immu-nology,immunotherapy has reached an exciting phase in its evolution for the treatment of cancer(Hart,2005;Onji and Akbar,2005).Although an effective immunotherapeutic regimen has yet not been dem-onstrated in the clinical setting and the ultimate role of immunotherapy in the treatment of glioma is still unknown,the potential for immunotherapy as an adjunct to the current treatment of gliomas is now based on solid evidence(Yu et al.,20… 相似文献
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Pek Leng NG Nor Fadilah RAJAB Sue Mian THEN Yasmin Anum MOHD YUSOF Wan Zurinah WAN NGAH Kar Yong PIN Mee Lee LOOI 《Journal of Zhejiang University. Science. B》2014,(8)
研究目的:探讨蒌叶(PB)提取物对5-氟尿嘧啶(5-FU)抑制结肠癌细胞HT29和HCT116生长的影响。研究方法:HT29和HCT116细胞分别给予PB、5-FU以及两种药物联合治疗24小时,应用等效线图法分析PB和5-FU的药效学相互作用,Annexin V/PI染色法检测HT29和HCT116细胞的凋亡情况,高效液相色谱法排除PB和5-FU间任何可能的相互化学作用。重要结论:联合PB,低剂量5-FU可以在短时间内起到细胞毒作用,而单独应用PB或5-FU治疗较联合治疗可以诱导更多细胞发生凋亡。进一步采用等效线图法分析显示PB和5-FU的联合作用在抑制结肠癌细胞HT29和HCT116的生长中分别体现出协同和拮抗作用。因此可以认为在HT29细胞中,PB使得较低剂量5-FU发挥最大抑制结肠癌细胞生长效果,然而在HCT116细胞中,PB没有显著降低5-FU的药物浓度,说明PB和5-FU的相互作用不仅仅体现在诱导细胞凋亡方面。 相似文献
60.
Simbita A. Marwah Hitesh Shah Kiran Chauhan Amit Trivedi N. Haridas 《Indian journal of clinical biochemistry : IJCB》2014,29(2):161-166
Currently employed markers for the detection of acute coronary syndrome are Troponin T, CK (Creatine Kinase) and CKMB activity. CKMB activity measured by immunoinhibition method can give falsely elevated results due to the presence of atypical CK and CKBB and at times lead to the mis-diagnosis of acute coronary syndrome. Hence, CKMB mass (CKMB) measured by electrochemiluminence sandwich principle was employed. In this cross-sectional study 183 samples of 61 patients were analyzed within 6 h of diagnosis of acute coronary syndrome and followed up to 72 h. The correlation coefficient between CKMB activity and CKMBM at 4–6 h was 0.744, while at 12–24 h it was 0.909 and at 48–72 h it was 0.337. Thus there was good association between the two methods at 12–24 h but, statistically for method comparison studies and for replacing one method by another, the two methods need to be in agreement with one another. In this study the two methods are not in agreement with one another and thus analytically not replaceable. Another finding was obtained that CKMBM reached cut off levels prior to CKMB enzyme activity and hence, CKMBM is clinically better than CKMB activity to detect reinfarction. 相似文献