The role of gene DCDC2 in German dyslexics

Dyslexia is a complex reading and writing disorder with a strong genetic component. In a German case-control cohort, we studied the influence of the suspected dyslexia-associated gene DCDC2. For the first time in a German cohort, we describe association of a 2445 basepair deletion, first identified in an American study. Evidence of association for three DCDC2 single nucleotide polymorphisms (rs807724, rs793862, rs807701), previously identified in German or American cohorts, was replicated. A haplotype of these polymorphisms showed evidence for association as well. Thus, our data further corroborate association of DCDC2 with dyslexia. Analysis of functional subgroups suggests association of investigated DCDC2 variants mainly with nondysphonetic, nonsevere, but probably dyseidetic (surface) dyslexia. Based on the presumed function of DCDC2, our findings point to a role of impaired neuronal migration in the etiology of the disease. Electronic supplementary material  The online version of this article (doi:) contains supplementary material, which is available to authorized users.

“Everyone Needs a Class Like This”: High School Students' Perspectives on a Gay and Lesbian Literature Course

Abstract

This article offers insights on how students experienced and made sense of their learning in a trimester-long high school Gay and Lesbian Literature course. Drawing on questionnaires and interviews that the students completed as part of a larger ethnographic study of this class, the author shows how a queer-themed literature curriculum is relevant for both LGBTQ-identifying and straight–identifying students and contributes to a better school climate.     

Self‐efficacy,goal orientation,and fear of failure as predictors of school engagement in high school students

Lack of school engagement among adolescents in this country remains a problem that can have very serious consequences including increased risk for school dropout, substance use, teenage pregnancy, and criminal activity. Clearly, identification of psychological variables (self‐variables) of individuals that facilitate or hinder adolescents' levels of school engagement would contribute greatly to the understanding of how to increase adolescents' psychological well‐being and their achievement motivation and associated school engagement. The present study examined the degree of association of three specific self‐variables (self‐efficacy, goal orientation, and fear of failure) with school engagement for high school students. The results and implications for intervention and future research are addressed. © 2003 Wiley Periodicals, Inc. Psychol Schs 40: 417–427, 2003.     

An investigation of a novel three-dimensional activity monitor to predict free-living energy expenditure

The aim of this study was to assess the capability of the 3dNX accelerometer to predict energy expenditure in two separate, free-living cohorts. Twenty-three adolescents and 14 young adults took a single dose of doubly labelled water and wore a 3dNX activity monitor during waking hours for a 10-day period while carrying out their normal routines. Multiple linear regression with backward elimination was used to establish the strength of the associations between various indices of energy expenditure, physical activity counts, and anthropometric variables. 3dNX output accounted for 27% and 35% of the variance in the total energy expenditure of the adolescent and young adult cohort, respectively. The explained variance increased to 78%, with a standard error of estimate of 7%, when 3dNX output was combined with body composition variables. The 3dNX accelerometer can be used to predict free-living daily energy expenditure with a standard error of estimate of 1.65 MJ in adolescents and 1.52 MJ in young adults. The inclusion of anthropometric variables reduces the error to approximately 1 MJ. Although it remains to cross-validate these models in other populations, early indications suggest that the 3dNX provides a useful method of predicting energy expenditure in free-living individuals.     

Museums and Technology: Being Inclusive Helps Accessibility for All

This paper explores accessibility issues for museums in the context of growing dependence on technology. The background of these issues is described, along with the evolution from physical access to digital access—for example, via the Web—and, increasingly, mobile technology. The authors are people with different disabilities and they describe personal experiences, giving a sense of the various barriers and benefits that are involved. The aim of this paper is to provide museums with a disabled person's point of view, which could help in inspiring improvements for the future. Often the task is one of understanding as much as financial constraints, since many solutions can be implemented at little additional cost.     

Comparison of two Actigraph models for assessing free-living physical activity in Indian adolescents

Abstract

This aim of this study was to compare the new Actigraph (GT1M) with the widely used Model 7164. Seven days of free-living physical activity were measured simultaneously using both the Model 7164 and GT1M in 30 Indian adolescents (mean age 15.8 years, s = 0.6). The GT1M was on average 9% lower per epoch than model 7164, thus a correction factor of 0.91 is suggested for comparison between the two monitors. The differences between monitors increased in magnitude with intensity of activity (P < 0.001) but remained randomly distributed (r = 0.01, P = 0.96). No significant difference was observed between monitors for time spent in moderate (P = 0.31) and vigorous (P = 0.34) physical activity when using the same epoch length. The Model 7164 classified less time as sedentary (P < 0.001) and more time as light-intensity activity (P < 0.001) than the GT1M. In conclusion, data from the GT1M can be compared with historical data using average counts per minute with a correction factor, and the two models might be comparable for assessing time spent in moderate to vigorous physical activity in children when using the same epoch length.