Role of Oxidative Stress in Various Stages of Psoriasis

Psoriasis is a chronic inflammatory, proliferative skin disease characterized by pathological skin lesions due to various exogenous and endogenous factors. It is associated with a number of biochemical and immunological disturbances. Recently, it has been suggested that increased reactive oxygen species (ROS) production and compromised function of antioxidant system may be involved in the pathogenesis of this disease. In the present study, 90 psoriasis patients were selected. Disease severity was assessed by psoriasis area severity index score and grouped as mild, moderate and severe (each group consists of 30 subjects) and compared with 30 healthy controls. Serum levels of malondialdehyde, nitric oxide end products and the activities of antioxidant enzymes such as erythrocyte-superoxide dismutase, catalase and total antioxidant status were investigated in these groups/subjects. As compared to controls, we found severitywise significantly increased serum malondialdehyde, nitric oxide end products with decrease in erythrocyte-superoxide dismutase activity, catalase activity and total antioxidant status in patients with psoriasis suggesting worsening of the disease. It seems to be linked with the enhancement of Reactive Oxygen Species production and decreased antioxidant potential in psoriasis.     

Dynamic mental models in learning science: The importance of constructing derivational linkages among models

We present a theory of learning in science based on students deriving conceptual linkages among multiple models which represent physical phenomena at different levels of abstraction. The models vary in the primitive objects and interactions they incorporate and in the reasoning processes that are used in running them. Students derive linkages among models by running a model (embodied in an interactive computer simulation) and reflecting on its emergent behaviors. The emergent properties they identify in turn become the primitive elements of the more abstract, derived model. We describe and illustrate derivational links among three models for basic electricity: a particle model, an aggregate model, and an algebraic model. We then present results of an instructional experiment in which we compared high school students who were exposed to these model derivations with those who were not. In all other respects, both groups of students received identical instruction. The results demonstrate the importance of enabling students to construct derivational linkages among models, both with respect to their understanding of circuit theory and their ability to solve qualitative and quantitative circuit problems. © 1999 John Wiley & Sons, Inc. J Res Sci Teach 36: 806–836, 1999     

Televised violence and viewers’ perceptions of social reality: The Korean case

This study attempts to describe some possible elaborations of the cultivation hypothesis and present relevant evidence from a Korean student sample. Using the postulates and methodology of the cultivation analysis approach to mass communication, this investigation employs a two‐pronged research strategy: message system analysis and cultivation analysis. Message system analysis consisted of one‐week sample of Korean television programs from the three television networks in June 1991. For cultivation analysis, a questionnaire was administered to 1,200 Korean students attending eight junior and senior high schools from five different states in July, 1991. Within the clear limitations of measures, the results suggested that viewers differentially perceive the social reality of different content types. The findings seem to indicate that the degree of cultivation effects is not uniform across different kinds of television programming.     

Association of Aberrations in One Carbon Metabolism with Intimal Medial Thickening in Patients with Type 2 Diabetes Mellitus

The present work was aimed to study the association of one carbon genetic variants, hyperhomocysteinemia and oxidative stress markers, i.e., serum nitrite, plasma malondialdehyde (MDA) and glutathione (GSH) on intimal medial thickening (IMT) in patients with type 2 diabetes mellitus (T2D). A total number of 76 subjects from ACS Medical College and Hospital, Chennai, India were included in the study, i.e., Group I (n = 42) of T2D and Group II (n = 34) of age- and sex matched healthy controls. The glycated haemoglobin was measured by ion-exchange resin method; plasma homocysteine by Enzyme Linked Immunosorbant Assay method; serum nitrite (nitric oxide, NO), plasma MDA and GSH by spectrophotometric methods; the IMT by high frequency ultrasound. The polymorphisms of one carbon genetic variants were genotyped using polymerase chain reaction-restriction fragment length polymorphism and amplified fragment length polymorphism methods. Results indicate that methyltetrahydrofolate homocysteine methyl transferase (MTR) A2756G allele was found to be protective in T2D and the other variants were not significantly associated with T2D. Glutamate carboxypeptidase II (GCP II) C1561T (r = 0.34; p = 0.05) and methylene tetrahydrofolate reductase (MTHFR) C677T (r = 0.35; 0.04) showed positive correlation with plasma homocysteine in T2D cases. In this study, MTR A2756G allele was found to be protective in T2D; GCP II C1561T and MTHFR C677T showed positive association with plasma homocysteine in T2D cases. Among all the genetic variants, MTR A2756G was found influence IMT. RFC 1 G80A and TYMS 5′-UTR 2R3R showed synergistically interact with MTR A2756G in influencing increase in IMT.     

An exploration of the interactions among the components of an experienced elementary science teacher’s pedagogical content knowledge

This study had two purposes: to explore the components of the pedagogical content knowledge (PCK) of an experienced elementary science teacher and to reveal the presumed interactions among these components. A naturalistic inquiry was conducted as a single case study in which in-depth qualitative data were gathered through semi-structured interview questions. After the theory-based and data-driven analysis of the qualitative data, the verbal communication was quantitated into numerical data for the enumerative analysis. The results revealed that the teacher’s knowledge of students’ understanding and difficulties, knowledge of the elementary science curriculum and knowledge of instructional strategies and representations were found to be mostly intersected PCK components, whereas orientations towards teaching science and knowledge of assessment in science had limited connections to the other components. Further discussions and context-based suggestions are given regarding professional development programmes.     

Choice of Academic Major at a Public Research University: The Role of Gender and Self-Efficacy

Females are underrepresented in certain disciplines, which translates into their having less promising career outlooks and lower earnings. This study examines the effects of socio-economic status, academic performance, high school curriculum and involvement in extra-curricular activities, as well as self-efficacy for academic achievement on choices of academic disciplines by males and females. Disciplines are classified based on Holland’s theory of personality-based career development. Different models for categorical outcome variables are compared including: multinomial logit, nested logit, and mixed logit. Based on the findings presented here, first generation status leads to a greater likelihood of choosing engineering careers for males but not for females. Financial difficulties have a greater effect on selecting scientific fields than engineering fields by females. The opposite is true for males. Passing grades in calculus, quantitative test scores, and years of mathematics in high school as well as self-ratings of abilities to analyze quantitative problems and to use computing are positively associated with choice of engineering fields.     

Between Turk and Muslim: children and the Qur’an courses after the 1928 Alphabet Law

ABSTRACT

This paper examines how the religious education of Turkish children in the “old letters” became an area of everyday contestation between the state and families and communities in the late 1920s and 1930s. Since children were seen as the nation’s future, state authorities were adamant about teaching the new generation the new alphabet and were equally interested in preventing them from learning the old alphabet. While schools began using the new Turkish alphabet in the 1928–1929 academic year, the informal neighbourhood Qur’an courses held in mosques and private homes became a fiercely contested site between a state determined to socialise children into secular nationhood (partly) by preventing them from learning the Arabic letters, and families and imams who were committed to giving children religious education (necessitating the study of the Arabic alphabet so the Qur’an could be read in its original Arabic). Combining primary sources from previously untapped Ministry of the Interior documents concerning the monitoring in Anatolian towns of these informal courses with insights from the subaltern school on everyday forms of resistance, this article sheds light on a dimension of the 1928 alphabet reform that ties together questions of alphabet change, national and religious identities, education, and childhood.     

Poststructural feminist pedagogy in English instruction of vocational-and-technical education

The purpose of this study was to develop a poststructural feminist pedagogical model and to investigate whether vocational-and-technical college students receiving poststructural feminist instruction would exhibit better learning achievement and critical thinking ability, and express greater satisfaction with their classes than those receiving traditional instruction. In applying a poststructural feminist model, the researchers intended to help both the teacher and students work together to overcome the estrangement and alienation that have long been the norm in the contemporary Chinese education system. The research results show that the poststructural feminist pedagogy had a positive effect upon the participants in the experimental group. Several conclusions are elicited from the study. First, in the English language achievement post-test, the participants receiving the poststructural feminist instruction significantly outperformed those receiving the traditional banking instruction in terms of listening, vocabulary, grammar, and reading. Second, in the critical thinking ability post-test, the participants significantly outperformed those receiving the traditional banking instruction in terms of length, focus, content, organization, and style. Third, in regard to the students’ satisfaction, it was clearly shown that the students who received the instruction informed by poststructural feminist pedagogy expressed significantly greater satisfaction than those who had received traditional banking instruction in terms of instructional objective, teaching method/materials, teacher quality, class environment, and assessment.     

论苏童笔下的“颂莲”式女性

苏童是少数几个尤其擅长写女性的男性作家。他对女性的心理描写和细节把握都处理得恰到好处,非常自然。他笔下的女性一改过往的温柔善良、知书达理,相反的,大多都阴暗猥琐、粗俗野蛮、善于妒忌,非常具有特色,成为中国当代女性小说的独有景观。苏童的几个从女性视角描写的女主人公具有很多的共同特征,他将这些女性称为“颂莲”式女性。     

Whitehead's Contribution to Ecological Thought: Some Unrealized Possibilities

The organizers of this conference have given me a difficult task: that of finding heretofore unfound implications of Whitehead's philosophy for environmental thought. The task is not difficult because implications of Whitehead's philosophy for environmental thought are hard to find. They are easy to find. The problem is that so many people have found them that finding something new to say is not easy.In what follows, however, some new implications are actually ferreted out. They fall under three headings: a) the interrelations between three ways of thinking about the environment: bioregionalism, land ethics, and the philosophy of organism; b) the implications of Whitehead's philosophy of organism for environmental aesthetics; and c) the implications of Whitehead's philosophy of organism for human communities (sustainable communities) viewed as interfused with living nature.