显微网络互动多媒体系统在遗传学实验教学中的应用效果

在遗传学实验教学中运用显微网络互动多媒体系统,弥补了单纯使用显微镜的不足;教师的演示、学生的反馈更及时,教师的指导更具有针对性,并加强了信息沟通和互动;强大的图片采集、保存与处理功能,有利于激发学生的实验兴趣,有利于加深对理论知识的理解;多画面的监控转播功能,可控制教学进度,提高实验课程效率和教学效果。     

论中外合作办学的可持续发展

当前,中外合作办学面临新的机遇与挑战。要实现中外合作办学可持续发展,必须遵循中外合作办学的基本规律,坚持引进优质教育资源的原则,坚持公益性原则,完善评估机制,加强质量监控与管理,坚持规范办学,严格依法管理。     

高校学生自导学习及模式探究——从学习者的角度

随着现代社会的快速发展,对人的学习方式提出不同的要求,而自我导向学习是适应未来社会需求的有效途径之一。从自导学习的相关概念出发,探讨高校学生自导学习的可行性和必要性,并提出相适应的自导学习模式。     

高职电子类专业“CDIO实践教学模式”探索

分析了传统高职电子类专业实践教学存在的主要问题,建立并实施了CDIO实践教学模式。结果表明：＂CDIO实践教学模式＂能够以接近电子工程实际所涉及的综合设计项目为主要载体,结合电子类实践环节的教学,使学生在CDIO的全过程中不断地在电子工程基础知识、个人能力、团队能力和工程系统能力4个方面得到全面的训练和提高。     

浅谈科教电视节目的策划

从受众角度指出目前的科教电视节目存在的问题,并在此基础上浅析科教电视节目策划的必要性,同时提出对科教电视节目进行策划的几点建议。     

Convergent genomic signatures of high-altitude adaptation among domestic mammals

Abundant and diverse domestic mammals living on the Tibetan Plateau provide useful materials for investigating adaptive evolution and genetic convergence. Here, we used 327 genomes from horses, sheep, goats, cattle, pigs and dogs living at both high and low altitudes, including 73 genomes generated for this study, to disentangle the genetic mechanisms underlying local adaptation of domestic mammals. Although molecular convergence is comparatively rare at the DNA sequence level, we found convergent signature of positive selection at the gene level, particularly the EPAS1 gene in these Tibetan domestic mammals. We also reported a potential function in response to hypoxia for the gene C10orf67, which underwent positive selection in three of the domestic mammals. Our data provide an insight into adaptive evolution of high-altitude domestic mammals, and should facilitate the search for additional novel genes involved in the hypoxia response pathway.     

Injectable hybrid inorganic nanoscaffold as rapid stem cell assembly template for cartilage repair

Cartilage injuries are often devastating and most cannot be cured because of the intrinsically low regenerative capacity of cartilage tissues. Although stem-cell therapy has shown enormous potential for cartilage repair, the therapeutic outcome has been restricted by low survival rates and poor chondrocyte differentiation in vivo. Here, we report an injectable hybrid inorganic (IHI) nanoscaffold that facilitates fast assembly, enhances survival and regulates chondrogenic differentiation of stem cells. IHI nanoscaffolds that strongly bind to extracellular matrix (ECM) proteins assemble stem cells through synergistic 3D cell–cell and cell–matrix interactions, creating a favorable physical microenvironment for stem-cell survival and differentiation in vitro and in vivo. Additionally, chondrogenic factors can be loaded into nanoscaffolds with a high capacity, which allows deep, homogenous drug delivery into assembled 3D stem-cell-derived tissues for effective control over the soluble microenvironment of stem cells. The developed IHI nanoscaffolds that assemble with stem cells are injectable. They also scavenge reactive oxygen species and timely biodegrade for proper integration into injured cartilage tissues. Implantation of stem-cell-assembled IHI nanoscaffolds into injured cartilage results in accelerated tissue regeneration and functional recovery. By establishing our IHI nanoscaffold-templated 3D stem-cell assembly method, we provide a promising approach to better overcoming the inhibitory microenvironment associated with cartilage injuries and to advance current stem-cell-based tissue engineering.     

区域一体化对城市创新能力驱动研究——基于长三角的实证分析

长三角更高质量一体化发展标志着各种资源要素在长三角区域内的配置效率将进一步提升,有利于形成更强的区域创新能力。本文基于2005—2017年长三角城市统计数据,考察了区域一体化对城市创新能力的驱动作用,并对其中的影响机制和异质性进行了深入分析。结果显示：(1)区域一体化对长三角城市创新能力具有显著的促进作用。(2)机制分析发现,一体化伴随的产业集聚并未形成创新能力提升机制,但一体化推动的区域内部产业转移机制有效提升了城市创新能力。(3)异质性分析表明,长三角区域一体化对非核心城市、欠发达城市、低财政分权城市具有更为显著的城市创新能力驱动作用。     

Water molecules bonded to the carboxylate groups at the inorganic–organic interface of an inorganic nanocrystal coated with alkanoate ligands

High-quality colloidal nanocrystals are commonly synthesized in hydrocarbon solvents with alkanoates as the most common organic ligand. Water molecules with an approximately equal number of surface alkanoate ligands are identified at the inorganic–organic interface for all types of colloidal nanocrystals studied, and investigated quantitatively using CdSe nanocrystals as the model system. Carboxylate ligands are coordinated to the surface metal ions and the first monolayer of water molecules is found to bond to the carboxylate groups of alkanoate ligands through hydrogen bonds. Additional monolayer(s) of water molecules can further be adsorbed through hydrogen bonds to the first monolayer of water molecules. The nearly ideal environment for hydrogen bonding at the inorganic–organic interface of alkanoate-coated nanocrystals helps to rapidly and stably enrich the interface-bonded water molecules, most of which are difficult to remove through vacuum treatment, thermal annealing and chemical drying. The water-enriched structure of the inorganic–organic interface of high-quality colloidal nanocrystals must be taken into account in order to understand the synthesis, processing and properties of these novel materials.     

网络舆论对伊朗突发新闻关注热点分析——以少将遇袭和导弹袭击事件中的微博为基础

本文探究网络舆论对伊朗突发新闻的关注热点,进而透过社交媒体分析网络舆论对国际热点事件的关注倾向.以含有关键词"伊朗少将遇袭"、"伊朗导弹袭击"和"伊朗"的所有微博作为研究数据,基于词频统计和LDA主题模型提取主题,从文本特征角度分析网络舆论对伊朗局势的关注热点.本研究对基于新浪微博数据检索到的文本内容进行分析发现,网络...