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21.
Amitabha Ray Anil Kumar Bahadur S. L. Dayalu Naik Bhuvnesh Kumar Sharma 《Indian journal of clinical biochemistry : IJCB》2001,16(2):199-202
Endogenous oestrogens are thought to be involved in breast cancer, but few studies could show the direct relationship between
hormones and pathological process of the disease. In the present study, oestradiol was estimated in the serum of pre-and postmenopausal
breast cancer patients along with normal healthy controls and patients with carcinoma of the uterine cervix which is not dependent
on oestrogens. Premenopausal patients with breast cancer showed higher levels of oestradiol as compared to premenopausal control
women as well as cervical cancer patients. Whereas, no statistically significant differences were observed in serum oestradiol
levels amongst postmenopausal groups of breast cancer, cervical cancer and normal women. The result of the study reflects
the association of oestradiol as well as its difference in the pathological events of pre and postmenopausal breast cancer. 相似文献
22.
Bhupendra Pal Singh Shailendra Dwivedi Urmila Dhakad Ramesh Chandra Murthy Vimal Kumar Choubey Apul Goel Satya Narayan Sankhwar 《Indian journal of clinical biochemistry : IJCB》2016,31(1):50-56
Deficiency or excess of certain trace elements has been considered as risk factor for prostate cancer. This study was aimed to detect differential changes and mutual correlations of selected trace elements in prostate cancer tissue versus benign prostatic hyperplasia tissue. Zinc, copper, iron, calcium and selenium were analysed in histologically proven 15 prostate cancer tissues and 15 benign prostatic hyperplasia tissues using atomic absorption spectrophotometer. Unpaired two tailed t test/Mann–Whitney U test and Pearson correlation coefficient were used to compare the level of trace elements, elemental ratios and their interrelations. As compared to benign prostatic tissue, malignant prostatic tissue had significantly lower selenium (p = 0.038) and zinc (p = 0.043) concentrations, a lower zinc/iron ratio (p = 0.04) and positive correlation of selenium with zinc (r = 0.71, p = 0.02) and iron (r = 0.76, p = 0.009). Considerably divergent interrelationship of elements and elemental ratios in prostate cancer versus benign prostatic hyperplasia was noted. Understanding of differential elemental changes and their interdependence may be useful in defining the complex metabolic alterations in prostate carcinogenesis with potential for development of element based newer diagnostic, preventive and therapeutic strategies. Further studies may be needed to elucidate this complex relationship between trace elements and prostate carcinogenesis. 相似文献
23.
Ajay Kumar T. A. Venkita Subramanian Usha P. Sharma 《Indian journal of clinical biochemistry : IJCB》1992,7(2):165-168
Protein fraction termed P2 was obtained from sonicates of Mycobacterium smegmatis, subjected to ammonium sulphate precipitation. P2 fraction was further fractionated into 4 fractions (PeakI-IV) by DEAE cellulose ion-exchange chromatography. ELISA was performed
on the sera of 104 tuberculous cases and 62 controls, using P2 fractions Peak I as test antigens. Though the mean ELISA values in tuberculous cases were higher than the controls, no statistically
significant difference was found between the two. Antigens P2, Peak I and IV were tested on Western blots with pooled sera from tuberculous cases as well as controls. P2 fraction, Peak-I and IV were separated on PAGE-SDS, electroblotted onto nitrocellulose Sheets and the blots were subjected
to ELISA. Peak IV appeared as a single band (M.W. 55,000). P2 fraction exhibited some discriminatory bands on development of blots. 相似文献
24.
R. Kumar S. B. Pachori G. K. Senger Satyanand L. D. Joshi 《Indian journal of clinical biochemistry : IJCB》1994,9(2):72-74
Aim of present study was to compare the adenosine deaminase (ADA) activity in various types of arthritis conditions with synovial
effusion. No. significant difference was observed in ADA activity in serum of control and study groups but results have shown
a definite pattern of ADA activity in synovial fluid in various arthritic conditions. The highest value of ADA activity was
observed in synovial fluid of patients with tubercular arthritis followed by rheumatoid, septic, osteo and post traumatic
arthritis. Thus measurement of ADA activity in synovial fluid can be used as a parameter of differential diagnosis of arthritis
specially tubercular in initial stages. 相似文献
25.
Vipin Kumar Mohamed Djemai Michael Defoort Muslim Malik 《Journal of The Franklin Institute》2021,358(1):674-698
In this article, we study the finite-time stability (FTS) and finite time stabilization problems for a class of switched impulsive systems evolving on an arbitrary time domain. This problem is formulated using time scale theory where the time domain can be continuous, discrete, union of disjoint intervals with variable gaps and variable lengths or any combination of these. Using common Lyapunov-quadratic and Lyapunov-like functions, we establish sufficient conditions to ensure the FTS results. Further, to solve the stabilization problem, we design state feedback controllers. We have illustrated the effectiveness of the obtained analytical results though numerical examples. 相似文献
26.
P-selectin, a cell adhesion molecule is elevated in many inflammatory conditions including preeclampsia which is characterized
by generalized endothelial dysfunction and vasoconstriction presumably due to free radicals or mediators released by defective
placentation. Vitamin E has been documented to protect cell membranes from oxidative damage and also decrease platelet aggregation.
The role of vitamin E in pre-eclampsia is contradictory and hence the study was undertaken. Soluble P-selectin was measured
by ELISA and Vitamin-E levels in plasma was estimated spectrofluorometrically. In our study the effect of supplementation
of 400 IU/day of Vitamin E (a-tocopheryl acetate) to patients of pre-eclampsia showed significant decreased levels of soluble
P-selectin by 2nd week as compared to patients given placebo (P = 0.005). In this short period of study no direct correlations were observed between Vitamin E or P-selectin levels with
blood pressure as well as with proteinuria. Future studies may focus on the effect of a-tocopheryl acetate or the phosphate
form of Vitamin-E, recently proposed to be the more active form on other inflammatory markers like IL-6, an important stimuli
of P-selectin release in pre-eclampsia. 相似文献
27.
We report a case of a diabetic, heterozygote with near normal hematology, marginally low level of hemoglobin A2(HbA2) having an increased level of hemoglobin F(HbF) that was pancellularly distributed among the red cells. BioRad DiaSTAT measurements
gave a high glycated hemoglobin A1c(HbA1c) of 31.5% and the BioRad Variant analyzer recorded an HbA1c value which was very
low, in discordance with the detected blood glucose levels. Flow cytometry and polymerization chain reaction (PCR) based studies
were carried out which revealed the case to be that of the common hereditary persistence of fetal hemoglobin (HPFH)-3, an
Asian Indian mutation. Fructosamine estimation and HbA1c by Boronate affinity chromatography were able to resolve the discordant
value detected and was able to confirm the diabetes status. The case would have been a diagnostic dilemma, if reported without
correlation. 相似文献
28.
Gupta S Verma M Gupta AK Kaur A Kaur V Singh K 《Indian journal of clinical biochemistry : IJCB》2011,26(2):178-181
Thyroid function tests are very important for the diagnosis and monitoring of patients with thyroid dysfunction. The guidelines
recommend serum thyroid stimulating hormone (TSH) as the single most reliable test to diagnose all common forms of hypothyroidism
and hyperthyroidism. The aim of this study was to analyze the ordering pattern for thyroid function tests by physicians and
the analysis of results based on the clinical history. The mean age of the patients was 32.5 ± 6.5 years. Majority of samples
(87.7% of total) were received from the departments of Medicine and Gynae. Thyroid profiles (47.5%) were ordered more frequently
as compared to TSH only (46%). There was no significant difference in the percentage of normal reports for both types of tests.
77.8% of TFT and 76.6% of TSH samples had results within the reference range. The percentage of abnormal results was 13.7%
in the patients who were screened for thyroid disorders. There is a need to redefine the case definition for thyroid dysfunction
and order the appropriate test in a rational and cost effective manner. 相似文献
29.
Singh B Goswami B Gupta VK Chawla R Mallika V 《Indian journal of clinical biochemistry : IJCB》2011,26(2):131-135
Ensuring quality of laboratory services is the need of the hour in the field of health care. Keeping in mind the revolution
ushered by six sigma concept in corporate world, health care sector may reap the benefits of the same. Six sigma provides
a general methodology to describe performance on sigma scale. We aimed to gauge our laboratory performance by sigma metrics.
Internal quality control (QC) data was analyzed retrospectively over a period of 6 months from July 2009 to December 2009.
Laboratory mean, standard deviation and coefficient of variation were calculated for all the parameters. Sigma was calculated
for both the levels of internal QC. Satisfactory sigma values (>6) were elicited for creatinine, triglycerides, SGOT, CPK-Total
and Amylase. Blood urea performed poorly on the sigma scale with sigma <3. The findings of our exercise emphasize the need
for detailed evaluation and adoption of ameliorative measures in order to effectuate six sigma standards for all the analytical
processes. 相似文献
30.
Upendra Yadav Pradeep Kumar Vandana Rai 《Indian journal of clinical biochemistry : IJCB》2021,36(1):23
Methionine synthase reductase (MTRR) is an important enzyme of the folate/homocysteine pathway. It is responsible for regulation of methionine enzyme by reductive methylation. A common variant A66G is reported in the FMN-binding domain of the MTRR gene, which leads to substitution of isoleucine by methionine (I22M) in MTRR enzyme with reduced activity. Reduced catalytic activity of enzyme leads to high homocysteine concentration in blood and increases risk for numerous diseases. The frequency of A66G polymorphism varies in different ethnic groups. The present study has been designed to evaluate the frequency of MTRR A66G gene polymorphism in the Eastern UP population by PCR–RFLP method. Along with this we also performed a meta-analysis to evaluate the global prevalence of this polymorphism. Databases were screened to identified the eligible studies. The prevalence of the G allele and GG genotype was determined by the use of prevalence proportion with 95% CI. Open meta-analyst software was used for the meta-analysis. Total 1000 blood samples were analyzed, the frequencies of A and G alleles were 0.35 and 0.65 respectively. Meta-analysis results revealed that the prevalence of G allele and GG genotype were 49.4% (95% CI 40.6–58.1, p ≤ 0.001) and 24.3% (95% CI 17.8–30.9, p ≤ 0.001) respectively. In sub-group meta-analysis, the lowest frequency of G allele was found in South America (32.7%; 95% CI 14.1–51.3, p ≤ 0.001), and highest in Asia (56.4%; 95% CI 39.5–73.3, p ≤ 0.001). The results of the meta-analysis showed that the Asian population has the highest frequency of G allele and highest frequency of the GG genotype was found in the European population. 相似文献