Evaluation of Surfactants-Assisted Folic Acid-Loaded Pectin Submicrospheres: Characterization and Hemocompatibility Assay

Folic acid is used for preventing and treating multiple diseases and disorders, administered in the form of oral supplements. The present research work was aimed to study the influence of two non-ionic surfactants Poloxamer and Tween 80 (Polysorbate 80) on pectin submicrospheres formulations. Typical natural polymer pectin was used to encapsulate folic acid by cross linking method. The resultant submicrospheres contributed to improve the aqueous solubility to enhance the bioavailability of folic acid. During investigation, it was observed that pectin polymers influenced kinetics of the rate of reaction more intensively than the surfactants. The physical phenomenon caused the change in their size, shape and chemistry of pectin polymers transforming into submicrospheres in aqueous condition. The characteristic differences of submicrospheres were assessed by scanning electron microscopy, differential scanning calorimetry and Fourier-transform infrared spectroscopy. The average diameters of the submicrospheres ranged between 250 and 500 nm. The encapsulation efficiency of submicrospheres ranged between 80 and 96 %. The characteristic swelling behavior of lyophilized submicrospheres was influenced by the ratio of pectin polymers and folic acid used in the formulations. The submicrospheres systems exhibited controlled release of folic acid due to the pH-dependent solubility of pectin polymers in aqueous medium. The submicrospheres showed good haemocompatibility suggesting them to be promising candidates for oral delivery.     

Evaluation of Oxidative Stress and hsCRP in Polycystic Ovarian Syndrome in a Tertiary Care Hospital

PCOS is a heterogeneous endocrine disorder with diverse clinical presentation. Oxidative stress plays a key role in the pathophysiology of this disease. Serumhigh sensitive C-reactive protein (hsCRP), a marker of chronic low grade inflammation, is indicative of future development of cardiovascular disease. Our aim is to evaluate the oxidant status and hsCRP levels in PCOS. The study involved 61 cases and 61 controls in the age group of 18–40 years diagnosed with PCOS. Erythrocyte malondialdehyde (MDA), superoxide dismutase (SOD), serum hsCRP, gonadotrophins, thyroid stimulating hormone, prolactin, glycemic status and lipid profile were estimated. Erythrocyte MDA (p < 0.001), SOD (p = 0.007) and serum hsCRP (p < 0.001) were significantly elevated in PCOS patients than controls. Oxidative stress is present in women with PCOS along with elevated hsCRP.     

排名前10的与预防运动和体育活动猝死相关的关键问题

参加有组织的体育运动和休闲活动存在发生严重伤病甚至死亡的内在风险。虽然造成体育运动或体育活动中猝死的原因有很多,但运动医学和循证标准治疗方面的进展已使临床医生得以更有效地预防、发现和治疗可能致死的伤患。随着研究与技术不断发展进步,当前的治疗标准正在不断发展以更好地改善患者的治疗效果。本文提出了10个与运动和体育活动中猝死的主要原因及其治疗手段有关的关键问题,未来开展的研究将提高运动员和休闲运动爱好者参与运动的安全度。当前证据表明,如采取正确的预防策略或最佳治疗方案,绝大多数的死亡案例是可以避免的。     

Analysis of publications of the pilot issue of the data collection of the All-Russia Institute of Scientific and Technical Information of the Russian Academy of Sciences “Industry of Nanosystems and Nanomaterials”

The pilot issue of the data collection of the All-Russian Institute of Scientific and Technical Information of the Russian Academy of Sciences “Industry of Nanosystems and Nanomaterials” gives an approximate view of the state of this field of science at the beginning of 2007. The topics of articles in the pilot issue are analyzed. The directions of development of nanotechnologies are shown. The basic types of nanomaterials, the methods of their production, and their properties and applications are given.     

Definitions of a “document”

Although the definition of a document has been the subject of a vast number of works, analysis of the latest publications shows that the question remains controversial. In this article the two definitions of “document” accepted as the broadest ones, i.e., the principal and conventional ones, are taken for examination. The principal definition of a document starts from the document as a part in the social information-communication process, therefore, having its place in it and performing a function that is major, and obligatory for the document. The conventional definition limits the scope of this concept, mostly in terms of material and characters, with allowance for specific features in the operation of documental communication systems.     

A web of science databases as a criterion for assessment of the research activities of Belarusian scientists

The publication activity of the scientists of the National Academy of Sciences of Belarus, the degree of reflection of their papers in Web of Science databases, and the data on the citation of Belarusian researchers in the studies of other scientists are discussed.     

Investigation of the flow of scientific-technical information on the basis of the Russian technical literature on nanostructures and nanotechnologies

The objective of this investigation of the Russian technical literature on nanostructures and nanotechnologies is a study of the dynamics and the cumulative number of publications (CPN) concerning nanostructures and nanotechnologies, the dynamics an2 CPN for different types of publications, the publication productivity of Russian scientists and Russian cities concerning nanostructures and nanotechnologies, the scientific activity of Russian scientific-research and educational institutions concerning nanostructures and nanotechnologies, the investigation of Russian periodicals and continuing publications concerning nanostructures and nanotechnologies, and the simulation of the CPN and prediction of the CPN for nanostructures and nanotechnologies.     

GaIN (Georgia Interactive Network for Medical Information) study on health professionals' search requests and continuing education needs

Health sciences librarians are being called upon to be more proactive in their institutions' continuing education efforts. In an effort to identify whether search requests indicated CE needs, a study was conducted by a group of members of GaIN (Georgia Interactive Network for Medical Information). MEDLINE requests from health care professionals for subject specific clinical topics were collected during a six-month period via a standard search request form created for the study. Copies of all completed requests were collected and broad ICD-9 codes assigned to the search topics. Institutional reports were generated for each participating library to share with hospital CE coordinators. They were also compiled for the group as a whole, and reflected the "hottest" topics requested during the study period for physicians and for non-physicians (nurses, allied health, administrators). A survey to hospital librarians and CE educators showed some value in the reports, but greater potential for further collaboration between librarians and CE coordinators.