A microfluidic device to study cancer metastasis under chronic and intermittent hypoxia

Metastatic cancer cells must traverse a microenvironment ranging from extremely hypoxic, within the tumor, to highly oxygenated, within the host''s vasculature. Tumor hypoxia can be further characterized by regions of both chronic and intermittent hypoxia. We present the design and characterization of a microfluidic device that can simultaneously mimic the oxygenation conditions observed within the tumor and model the cell migration and intravasation processes. This device can generate spatial oxygen gradients of chronic hypoxia and produce dynamically changing hypoxic microenvironments in long-term culture of cancer cells.     

Smoking and deaf adults: associations with age at onset of deafness

Smoking is a major health problem whose prevalence in different populations is thought to be influenced by sociocultural and linguistic factors. Although smoking and hearing loss are positively correlated, little is known about the smoking habits of deaf populations. Using national survey data, this study determined the smoking prevalence in two socioculturally distinct deaf populations, based on age at onset of deafness. The smoking prevalence in each deaf population was compared to the smoking prevalence in the hearing population in multivariate analyses that adjusted for sociodemographics and health status. The smoking prevalence among postlingually deafened adults was not significantly different from that among hearing adults. Prelingually deafened adults were found to be less likely to smoke than hearing adults, even though they have less education and lower income, factors both associated with higher smoking prevalence in other populations. The lower smoking prevalence among prelingually deafened adults may be due to cultural differences or to limited access to English-language tobacco advertising.     

Earth surface modeling for education: How effective is it? Four semesters of classroom tests with WILSIM-GC

This paper presents results from a randomized experimental design replicated over four semesters that compared students’ performance in understanding landform evolution processes as measured by the pretest to posttest score growth between two treatment methods: an online interactive simulation tool and a paper-based exercise. While both methods were shown to be effective at enhancing students’ learning of the landform concepts and processes, there was no statistically significant difference in score growth between the two instructional methods. However, the attitudinal survey indicated that students consistently favored the simulation approach over the paper-based exercise. With the simulation method, female students showed greater score growth than males, especially for test items requiring higher level thinking. This indicates that the visually rich interactive simulation tool may be integrated to better support female students’ learning in geoscience. Science major students generally outperformed non-science major students in terms of score growth, which suggests that background knowledge played an important role in realizing the potential of computer modeling in enhancing students’ learning. Sufficient scaffolding is necessary to maximize the effect of interactive earth surface modeling in geoscience education.     

Geo-Policy Barriers and Rural Internet Access: The Regulatory Role in Constructing the Digital Divide

A combination of geography, public policy, and commercial investment in information infrastructure combines to create geo-policy barriers that in turn structure the ability of rural citizens to access the Internet. A statistical study of 208 rural telephone exchanges in Texas combined with case studies from rural counties explores the impact of distance and policies aimed at enabling rural telephone connection on the presence of Internet service providers. Market territories, including exchange areas and LATAs, and the distance requirements of expanded local calling policy in Texas can both help and hinder Internet access in remote areas.     

Through the camera's eye: A phenomenological analysis of teacher subjectivity

The purpose of this study is to understand how preservice teachers experience a common university assignment: the videotaping and analysis of their own instruction. Using empirical data and the thought of the French philosophers Michel Foucault and Emmanuel Levinas, the study examines the difficulties in transitioning from student subjectivity to teacher subjectivity within the context of university-based teacher education. The paper ends by considering the role teacher educators can play in helping student teachers grow through their preservice experiences.     

The AECT Project: Modeling the Effective Use of Technology in Teacher Preparation

Conclusion The AECT Project builds on ISTE’s groundbreaking work in the development of technology standards for teachers. The Project adds specificity and has developed a comprehensive set of tools for pre-service teacher education. Teacher educators can use these tools to ensure that their graduates leave with the technology skills needed for their selected teaching specialty. The commitment and leadership demonstrated by the U.S. Department of Education in offering the Preparing Tomorrow’s Teachers for Technology program has earned their leaders our respect. Through this program the AECT Project has been able to develop tools and can now offer them at no cost to institutions of higher education. The PT3 Program has galvanized educators across America, has helped to create important, ongoing collaborations, and has helped to instill an unprecedented mass consciousness valuing educational change. The partners in the AECT Project are proud to have this opportunity to contribute, in important ways, to technology integration in teacher education. We are honored to join with all of the other PT3 Projects from across the Nation in creating teaching and learning opportunities that will shape our educational systems in the 21st century. We welcome other teacher education institutions and professional associations as partners as we move ahead. For more information, please contact us through our Website athttp://aect.org/pt3, or send email to us ataect@psu.edu