Polymorphisms within the COL5A1 gene and regulators of the extracellular matrix modify the risk of Achilles tendon pathology in a British case-control study

Several genetic loci have been associated with risk of Achilles tendon pathology (ATP) within South African and Australian populations. The aim of this study was, therefore, to evaluate eight previously implicated genetic variants in an independent British population. A total of 130 asymptomatic controls (CON) and 112 participants clinically diagnosed with ATP comprising 87 individuals with chronic Achilles tendinopathy (TEN) and 25 with Achilles tendon ruptures (RUP) were included. All participants were genotyped for variants within the COL5A1, MIR608, IL-1β, IL-6 and CASP8 genes. Primary findings implicated COL5A1 and CASP8. Three inferred allele combinations constructed from COL5A1 rs12722, rs3196378 and rs71746744 were identified as risk modifiers. The T–C–D combination was associated with increased risk of ATP (P = 0.023) and RUP (P < 0.001), the C–A–I combination was associated with increased risk of ATP (P = 0.011), TEN (P = 0.011) and RUP (P = 0.011) and the C–C–D combination was associated with decreased risk of ATP (P = 0.011) and RUP (P = 0.004). The CASP8 rs3834129 DD genotype was associated with decreased risk of TEN (P = 0.020, odds ratio: 0.45, 95% confidence interval: 0.22–0.90) and the CASP8 I–G (rs3834129–rs1045485) inferred allele combination was associated with increased risk of TEN (P = 0.031). This study further highlights the importance of polymorphisms within COL5A1 and CASP8 in the aetiology of ATP.     

A Maximal Graded Exercise Test to Accurately Predict VO2max in 18–65-Year-Old Adults

The purpose of this study was to develop an age-generalized regression model to predict maximal oxygen uptake (VO_2max) based on a maximal treadmill graded exercise test (GXT; George, 1996) George, J. D. 1996. Alternative approach to maximal exercise testing and VO_2max prediction in college students. Research Quarterly for Exercise and Sport, 67: 452–457. [Taylor & Francis Online], [Web of Science ®] , [Google Scholar]. Participants (N?=?100), ages 18–65 years, reached a maximal level of exertion (mean?±?standard deviation [SD]; maximal heart rate [HR_max]?=?185.2?±?12.4 beats per minute (bpm); maximal respiratory exchange ratio [RER_max]?=?1.18?±?0.05; maximal rating of perceived exertion (RPE_max)?=?19.1?±?0.7) during the GXT to assess VO_2max (mean?±?SD; 40.24?±?9.11 mL·kg^?1·min^?1). Multiple linear regression generated the following prediction equation (R?=?.94, standard error of estimate [SEE]?=?3.18 mL·kg^?1·min^?1, %SEE?=?7.9): VO_2max (mL·kg^?1·min^?1)?=?13.160?+?(3.314 × gender; females?=?0, males?=?1) ? (.131 × age) ? (.334 × body mass index (BMI))?+?(5.177 × treadmill speed; mph)?+?(1.315 × treadmill grade; %). Cross validation using predicted residual sum of squares (PRESS) statistics revealed minimal shrinkage (R_p ?=?.93 and SEE _p ?=?3.40 mL·kg^?1·min^?1); consequently, this model should provide acceptable accuracy when it is applied to independent samples of comparable adults. Standardized β-weights indicate that treadmill speed (.583) was the most effective at predicting VO_2max followed by treadmill grade (.356), age (?.197), gender (.183), and BMI (?.148). This study provides a relatively accurate regression model to predict VO_2max in relatively fit men and women, ages 18–65 years, based on maximal exercise (treadmill speed and grade), biometric (BMI), and demographic (age and gender) data.     

Continuing Research by PhD Graduates

A survey of Australian PhD graduates has revealed that they do not necessarily fit traditional stereotypes in terms of age, previous or concurrent work experience nor, perhaps most importantly, a prospective career in research. Two years after graduating with PhD, just 36 per cent of those who found employment in the non-academic workforce continued to be 'xtensively' involved in research, while only 56 per cent of those in academic employment (other than those with postdoctoral fellowships) were so involved. Many of those trained in research are frustrated in not being able to implement and extend that training through appropriate employment, others who have the opportunity do not have the desire. Factors predictive of and related to continuing involvement in research are examined, with some surprising results and policy implications regarding postgraduate research degrees.     

Influence of a Reflective Explicit Activity‐Based Approach on Elementary Teachers' Conceptions of Nature of Science

This study assessed the influence of a reflective, explicit, activity‐based approach to nature of science (NOS) instruction undertaken in the context of an elementary science methods course on preservice teachers' views of some aspects of NOS. These aspects included the empirical, tentative, subjective (theory‐laden), imaginative and creative, and social and cultural NOS. Two additional aspects were the distinction between observation and inference, and the functions of and relationship between scientific theories and laws. Participants were 25 undergraduate and 25 graduate preservice elementary teachers enrolled in two sections of the investigated course. An open‐ended NOS questionnaire coupled with individual interviews was used to assess participants' NOS views before and at the conclusion of the course. The majority of participants held naive views of the target NOS aspects at the beginning of the study. During the first week of class, participants were engaged in specially designed activities that were coupled with explicit NOS instruction. Throughout the remainder of the course, participants were provided with structured opportunities to reflect on their views of the target NOS aspects. Postinstruction assessments indicated that participants made substantial gains in their views of some of the target NOS aspects. Less substantial gains were evident in the case of the subjective, and social and cultural NOS. The results of the present study support the effectiveness of explicit, reflective NOS instruction. Such instruction, nonetheless, might be rendered more effective when integrated within a conceptual change approach. © 2000 John Wiley & Sons, Inc. J Res Sci Teach 37: 295–317, 2000.     

Impairment of teacher efficiency during extended sessions of test correction

SUMMARY The relationship between monotonous work, mental fatigue, and reduction in efficiency has been discussed at length in the literature. This paper examines a theory, based on the interactions revealed in those studies, that uninterrupted examination of a large number of tests over an extended period of time, leads to inconsistency in grading. Three specialists judged typed compositions of seventh-grade pupils, and independently awarded the grade of 80% to 31 papers. These compositions were submitted to 60 female teachers. Each teacher received all 31 papers, stacked in one of three different, randomly arranged sequences. The subjects, unaware of the earlier review, were asked to read the compositions in one sitting and in the order in which they were stacked, and to assign a grade. There was no communication between teachers in the project with regard to the task. The variable found to contribute significantly to the grading pattern was the order in which the essays were arranged. The first tests received lower grades, on average, than those awarded by the specialists. As the teachers worked their way through the stack, the grades gradually rose, and eventually exceeded those given by the specialists. The discrepancy between the mean evaluation of the first papers and last papers in the pile was approximately 10%. Teacher seniority and other variables tested did not contribute significantly to the process.     

Paradise Restored: The significance of coincidence in some children's books

Pat Pinsent is a Principal Lecturer in English at the Roehampton Institute, London, where she teaches children's literature to undergraduates as well as courses on language and literacy for in-service teachers.