Yangxueqingnao particles inhibit rat vascular smooth muscle cell proliferation induced by lysophosphatidic acid

Objective: To observe the effect of Yangxueqingnao particles on rat vascular smooth muscle cell (VSMC) proliferation induced by lysophosphatidic acid (LPA). Methods: The amount of3H-TdR (3H-thymidine) admixed in cultured rat VSMC was measured and mitogen-activated protein kinase (MAPK) activity and lipid peroxidation end product malondialdehyde (MDA)content of the VSMC were assayed. Results: 1×10-9, 1×10-8, 1×10-7 mol/L LPA in a concentration dependent manner, induced the amount of 3H-TdR admixed, MAP kinase activity, and MDA content of the cultured rat VSMC to increase. However, 5%, 10%,and 15% Yangxueqingnao serum preincubation resulted in a decrease of 23.0%, 42.0%, and 52.0% (P＜0.01) respectively in the amount of 3H-TdR admixed, a decline in VSMC MAP kinase activity of 13.9% (P＜0.05), 29.6% (P＜0.01), and 48.9% (P＜0.01)respectively, and also, a decrease in MDA content of VSMC of 19.4%, 24.7%, and 43.2% (P＜0.01) respectively, in the 1×10-7mol/L LPA-treated VSMC. Conclusions: LPA activates the proliferation and lipid peroxidation of VSMC in a concentration dependent manner. The LPA-induced VSMC proliferation is related to the activity of MAP kinases, enzymes involved in an intracellular signalling pathway. The results of the present study showed that Yangxueqingnao particles can effectively inhibit LPA-induced VSMC proliferation, MAP kinase activation, and reduce lipid peroxidative lesion.     

Oseen流动中粘性对自由表面波的影响

Based on the complex dispersion relation for the two-dimensional free-surface waves generated by a moving body in the steady Oseen flows, the effect of viscosity on wavelength and wave amplitude was investigated by means of an asymptotic method and a numerical analysis. A comparison between the asymptotic and numerical analysis for the viscous decay factor demonstrates the validity of the perturbation expansions for the wave profile. The numerical result shows that the wavelength of viscous wave is slightly elongated in comparison with that of inviscid wave.     

论邓小平对科学发展观的贡献

邓小平同志在半个多世纪的中国革命和建设中，继承和发展了毛泽东思想，创立了中国特色社会主义的发展理论．带领全党和全国各族人民开创了改革开放和社会主义现代化建设的新局面，为我党在新世纪、新阶段确立的科学发展观做出了伟大的历史性贡献。     

铝不能与氧化镁发生反应吗--谈金属与氧气反应趋势顺序的应用

有一道在中学化学中流传已久的习题:不能用铝热反应制备的金属是(B)。A.CrB.MgC.MnD.V显然,这类试题的答案是以金属活动性顺序为依据的。其实,金属活动性顺序是按水溶液中金属单质与其对应金属阳离子所组成电极的标准电极电位由小到大的顺序排列而成的,只能作为水溶液中某些反应的判据。铝热反应的判据应该是金属与氧气反应的趋势顺序,该顺序可以由金属与氧气反应生成相应氧化物的Ellingham图(如图1)得到。     

成人高校向普通高校转轨时期的学情分析及对策研究(二)——以新疆教育学院的转型为个案分析

在新的教育形势下,全日制成人高等院校面临着调整与转型。为了把握普高生与成人脱产生的差异,本文以新疆教育学院为个案,对普高生与成人脱产生在学习方法、学习过程、考试心态等方面的差异进行了调查与分析,并提出相应对策,以期为提高普高生的教学质量提供参考。     

法官道德与司法公正

法官道德是司法公正的必要条件之一,但二者之间又有诸多的联系,要想司法公正,法官道德是不可或缺的屏障,因此,对法官道德水准的要求至关重要。     

克莱姆法则在井字梁结构计算中的应用

本文以4×4方格简支井字梁计算为例,说明利用克莱姆法则可以推出井字梁各节点力的分配系数计算公式,从而更准确地计算出各节点所承受的作用力.     

医学院校兼职班主任管理工作浅谈

兼职班主任是学生管理工作的重要组成部分,是学科建设、专业建设的延伸。完善兼职班主任管理制度是强化兼职班主任工作的重要方法。对兼职班主任队伍进行管理,不仅能发挥专业教师在人才培养方面优势,对教师本身的思想认知、教育理念、带教水平、科研水平都会带来明显的优势。     

多重身份下的高校辅导员专业化建设探析

高校辅导员具有管理人员、教师等多重身份。通过分析多重身份下辅导员专业化建设的现状与困境,结合高校辅导员队伍建设的相关要求,提出有效的高校辅导员专业化的建设方式方法,进一步提升辅导员专业素质,稳定高校辅导员队伍。     

对开发和挖掘中职语文潜性课程的思考

中职语文蕴涵着深厚的人文精神和文化底蕴，有着丰富的语文潜性课程内容。中职语文教学，只有从语文教材、课堂教学和课外活动等层面，坚持本体性、适应性、主导性和沟通性原则，才能对中职语文潜性课程进行分类开发与挖掘。