Enhancing cellular immune response to HBV M DNA vaccine in mice by codelivery of interleukin-18 recombinant

Objective: To investigate the effect of interleukin-18 (IL-18) on immune response induced by plasmid encoding hepatitis B virus middle protein antigen and to explore new strategies for prophylactic and therapeutic HBV DNA vaccines. Methods: BALB/c mice were immunized with pCMV-M alone or co-immunized with pcDNA3-18 and pCMV-M and then their sera were collected for analysing anti-HBsAg antibody by ELISA; splenocytes were isolated for detecting specific CTL response and cytokine assay in vitro. Results: The anti-HBs antibody level of mice co-immunized with pcDNA3-18 and pCMV-M was slightly higher than that of mice immunized with pCMV-M alone, but there was not significantly different (P>0.05). Compared with mice injected with pCMV-M, the specific CTL cytotoxity activity of mice immunized with pcDNA3-18 and pCMV-M was significantly enhanced (P<0.05) and the level of IFN-γ in supernatant of splenocytes cultured with HBsAg in vitro was significantly elevated (P<0.05) while the level of IL-4 had no significant difference (P>0.05). Conclusion: The plasmid encoding IL-18 together with HBV M gene DNA vaccines may enhance specific TH1 cells and CTL cellular immune response induced in mice, so that IL-18 is a promising immune adjuvant.     

开放、多元、综合的艺术教育——美国艺术教育考察报告

本文通过对美国艺术教育的实地考察和分析 ,指出美国艺术教育是在人文科技视野下实施的开放、多元、综合的艺术教育 ,具有如下几个特点 :从教育内容看 ,是跨学科、多层面、综合的 ;从教学方法看 ,是探究性和多元化的 ;从教育途径看 ,是学校、社会和家庭积极合作、互动的 ;艺术教师队伍结构灵活、专兼并举、素质较高。作者还就改革和加强我国艺术教育提出了若干思考     

构建现代教育服务体系的理论与实践

大连教育学院为了很好地服务于本市新时期的初、中等教育,坚持科学发展观,积极构建现代教育服务体系:以"原野行动"服务于新农村建设的教师培训;以"大篷车计划"构建服务于教师专业发展的网络平台;以"空中课堂"服务于农村小学的英语教学;以"村小校长培训"服务于推进区域教育均衡发展的校长培训末梢工程;以"名师名校长培训"服务于全面实施素质教育的校长、教师培训;以"二二三四"工作服务于大连市的初、中等教育与教学。     

新时代高校思政课教师继续教育现状及对策研究

2018年《关于全面深化新时代教师队伍建设改革的意见》对教师继续教育提出了新要求,也为思政课教师的继续教育指明新方向和创新的新源泉.因此,文章在基于高校思政课教师继续教育现状分析的基础上,依据文件精神,紧紧把握政治方向,将文件精神融入继续教育全过程中,提出立德树人,强化继续教育德育功能;融合情景教育教学,构建"逆序创新"教育模式等对策,以解决新时代高校思政课教师继续教育所存在的问题.     

审美与创新

新的世纪,经济全球化,科技创新国际化,已成了知识经济时代的总体趋势。创新即生存、即发展,是支撑一个国家、一个民族的脊梁和灵魂。江泽民总书记强调指出:“创新是一个民族进步的灵魂,是一个国家兴旺发达的不竭动力。”很多专家学者或从经济发展、社会进步的角度,或从文化知识的角度,或从科技发展的角度,或从人类创造实践的角度,从理性上对创新进行了有益的研究和探讨,其中不乏真知灼见。但从审美的角度来对创新进行研究和探讨,却鲜有人为。本文拟从审美的角度,就创新谈自己的一管之见。     

利用语音识别引擎实现电脑英语语音测试的探索

介绍了作研发的一套英语语音测试系统软件，能利用计算机判断识别学生的语言，可代替教师进行英语语音测试的繁重工作。     

美国公司治理的变革及其对我国的启示

去年以来美国的公司丑闻频出，从美国政府到证券管理地此都做出了反应，进而提出了公司治理的改革方案。中首先介绍了美国公司治理模式及整个危机事件，然后分析了这次危机发生的原因和特点，介绍了公司改革法案的重点。最后对比我国的公司治理，指出了其对我国的借鉴意义，并对我国的公司治理提出一些改进见解。     

Kinetics study on biomass pyrolysis for fuel gas production

Kinetic knowledge is of great importance in achieving good control of the pyrolysis and gasification process and optimising system design. An overall kinetic pyrolysis scheme is therefore addressed here. The kinetic modelling incorporates the following basic steps: the degradation of the virgin biomass materials into primary products (tar, gas and semi-char), the decomposition of primary tar into secondary products and the continuous interaction between primary gas and char. The last step is disregarded completely by models in the literature. Analysis and comparison of predicted results from different kinetic schemes and experimental data on our fixed bed pyrolyser yielded very positive evidence to support our kinetic scheme. Project (No. 2001CB409600) Supported by the National Key Basic Research Program (973) of China     

前景化理论与英语新闻报道词汇的文体特征分析

系统功能语言学家韩礼德摒弃了偏离学的观点，把前景化定义有“有动因的突出”，主张从功能的角度研究文体，即每个次上的有文化价值的突出特征都要与产生本语篇的语境相关，都应是由上层所“促动的”，韩氏的理论是本文对英语新闻报道的文体特征分析的理论基础，英语新闻报道的词汇的文体特征是由其情景因素决定的，它的突出特征是受其语义特色促动的。     

Reform of Mathematics Curriculum and Open-ended Problem Solving

The basic assumption of reform mathematics is that ＂no one can teach mathematics＂. Therefore, the important teachers＇ role is to stimulate students to learn mathematics and support their development. Open-ended problem solving is an instructional strategy that creates interest and stimulates creative mathematical activity in the classroom through students＇ collaborative work. Lessons using openended problem solving problem solving activities result. emphasize the process of rather than focusing on the