On the influence of the architecture of poly(ethylene glycol)-based thermoresponsive polymers on cell adhesion

Thermoresponsive polymer surface coatings are a promising tool for cell culture applications. They allow for a mild way of cell detachment that preserves the activity of membrane proteins—a prerequisite for reliable cell analysis. To enlarge the application range of these coatings to cells with different adhesion properties, we synthesized various novel poly(ethylene glycol)-based thermoresponsive polymers and describe how (i) their chemical structure and (ii) their surface density affect their efficiency. In order to quantify the influence of both factors, the time for cell spreading and rounding efficiency were observed. As a result, efficiency of cell rounding, which is closely correlated to cell detachment, is less affected by both factors than the time needed for cell spreading. This time can effectively be adjusted by the molecular architecture which includes the length of the polymer backbone and the side chains. Based on this work, recommendations are given for future optimization of functionality of thermoresponsive polymer coatings for cell culture applications.     

A meta-evaluation of scientific research proposals: Different ways of comparing rejected to awarded applications

Combining different data sets with information on grant and fellowship applications submitted to two renowned funding agencies, we are able to compare their funding decisions (award and rejection) with scientometric performance indicators across two fields of science (life sciences and social sciences). The data sets involve 671 applications in social sciences and 668 applications in life sciences. In both fields, awarded applicants perform on average better than all rejected applicants. If only the most preeminent rejected applicants are considered in both fields, they score better than the awardees on citation impact. With regard to productivity we find differences between the fields. While the awardees in life sciences outperform on average the most preeminent rejected applicants, the situation is reversed in social sciences.     

Vom erwartbaren Erkenntnispotenzial der Auftragsforschung zu Sportvereinen

Sports club research has a long tradition in Germany and has produced a considerable variety of methodological approaches and theoretical as well as empirical knowledge. This article provides an epistemologically oriented determination and reflection of the potential of knowledge of current sports club research against the background of the tender objectives of the sports development report on waves 7 to 9 (SEB 3.0). It becomes clear that in conflict between normatively charged goals of the SEB—defined by the public client (principal)—non-judgmental, theory-guided and theory-based empirical sports club research is hardly possible. This means that it is rather difficult to carry out sports club research that is based on current research and is also able to generate new and reliable scientific knowledge. Therefore, a clearer differentiation is recommended between knowledge-guided research and normatively broken objectives aimed at policy advice. In dealing with these issues, methodological and methodological strategies are proposed to achieve the goals of SEB 3.0. At the same time, the chance of generating additional theoretical and empirical knowledge on the subject of “sports club” is increased.     

Muskuläre Regulation bei ermüdungsinduzierter Vorbelastung im Krafttraining

International sport strives for increasing the level of performance in sports. Risks of manipulating the performance are not unusual. At the same time, improvements in science, engineering and data processing offer further opportunities for planning effective, low-risk and year-round training programmes for specific sports. This paper presents new approaches based on the example of techniques for strength training. Selected experimental results highlight the limitations and provide conclusions for the scientific foundation and individualization of high performance training. The approach of “muscle pre-fatigue” is verified in a training study with high jumpers. The statements show how important scientifically controlled analysis is for individual training programmes and what high significance they have for optimizing the training process. These will be essential requirements for a legal improvement of high performance in international sport.     

The role of International Non-Governmental Organisations in promoting adult education for social change: A research agenda

This paper explores the role of International Non-Governmental Organisations (INGOs) in adult education as one instrument of global civil society to effect social change. Postcolonial theory is utilized to explore the complex relationships between the concepts of ‘globalisation’, ‘global civil, society’, and ‘adult education for social change’. In seeking change for social justice postcolonial theory examines the construction of cultural discourse within the epistemologies of (neo-) colonial and decolonising contexts, as well as how such discourse helps to shape and change social realities and identities. We propose a postcolonial research agenda for studying the adult education role of INGOs.