脑研究成果改进学校教学实践的范例——对风靡全美的整合性主题教学(ITI)模式的引介与评析

整合性主题教学模式(ITI)是由苏珊·J·克瓦列克及其研究会开发的颇具影响力的教育实践模式。在将脑科学研究成果融入教育实践中的尝试而言,ITI模式无疑是首创性的。在为期二十多年的实践与探索过程中,ITI模式逐步成熟与完善,对其的引介与分析,是颇具意义的工作。     

高职专业结构与区域产业结构适应性研究--以陕西省为例

近年来，陕西省高职教育专业设置数量递增，专业更新与调整速度加快，与三大产业结构整体分布情况基本相适应，但也存在与第二产业相关专业数量偏少、与第三产业相关专业设置数量偏大的不协调现象。从八大支柱产业的发展状况与需求来看，专业设置与之不相吻合。针对上述问题，建议建立与市场经济相适应的高职教育管理体系、与产业结构相适应的高职教育专业结构调整体系。     

Polymorphisms in genes involved in folate metabolism as maternal risk factors for Down syndrome in China

Objective: To explore the relationship between genetic polymorphisms in methylenetetrahydrofolate reductase (MTHFR), methionine synthase reductase (MTRR), the central enzymes in folate metabolism that affects DNA methylation and synthesis, and the risk of Down syndrome in China. Methods: Genomic DNA was isolated from the peripheral lymphocytes of 64 mothers of children with Down syndrome and 70 age matched control subjects. Polymerase chain reaction and restriction fragment length polymorphism were used to examine the polymorphisms of MTHFR 677C→T, MTRR 66A→G and the relationship between these genotypes and the risk of Down syndrome was analyzed. Results: The results show that the MTHFR 677C→T polymorphism is more prevalent among mothers of children with Down syndrome than among control mothers, with an odds ratio of 3.78 (95% confidence interval (CI), 1.78～8.47). In addition, the homozygous MTRR 66A→G polymorphism was independently associated with a 5.2-fold increase in estimated risk (95% CI, 1.90～14.22). The combined presence of both polymorphisms was associated with a greater risk of Down syndrome than the presence of either alone, with an odds ratio of 6.0 (95% CI, 2.058～17.496).The two polymorphisms appear to act without a multiplicative interaction. Conclusion: MTHFR and MTRR gene mutation alleles are related to Down syndrome, and CT, TT and GG gene mutation types increase the risk of Down syndrome.     

维果茨基游戏理论述评

维果茨基是前苏联一位才华横溢的心理学家。他的游戏理论主要包括对游戏的社会性本质的认识、游戏与幼儿发展的关系、游戏的关键特征、游戏的作用等。他的游戏理论为人们理解游戏提供了新的视角但同时也存在一定的局限性。     

课程内容选择的原则与倾向-对基础教育新课程标准设计者的访谈

本研究通过对几位亲身经历新课程课标设计的人员进行质化访谈的方式,呈现、分析课程设计过程中内容选择与体系组织的关键点、困扰及设计者的思考,以此提升对课程设计的影响因素、思维方式等问题的认识,并提示未来课程研究的着力点。     

Improvement in the Orthogonal Protein Degradation in Escherichia coli by Truncated mf-ssrA Tag

SsrA peptide tag from Mycoplasma florum has been developed as a versatile biotechnology tool to control orthogonal degradation of tagged proteins in Escherichia coli. Here, using the systematic deletion mutants of mf-ssrA tag, we demonstrated that the residues in two separate regions have different functions in mf-Lon-mediated specific orthogonal target protein degradation in E. coli. The deletion of multiple residues, up to six amino acids, did not fatally abolish its specific degradation activity, instead of being able to improve the stability of the tagged protein in the presence of endogenous proteases before mf-Lon expression in E. coli. Except for previously identified essential residues, the region adjacent to the C-terminal of the mf-ssrA tag was involved in mf-Lon and endogenous protease-mediated degradation. Moreover, the deletion of specific residues made the mf-ssrA tag more effective and compact. The mf-ssrA tag can be implemented in synthetic biology and bioengineering for development of synthetic circuits.     

简析"人的根本就是人本身"对思想政治教育的启示意义

马克思在《〈黑格尔法哲学批判〉导言》中有一段经典论述,这段论述对于揭示思想政治教育的合法性、有效性及根本途径有着重要的启示意义,其中“人的根本就是人本身”是这段论述的核心和精髓,对我们今天的思想政治教育工作富有重大的启示意义。     

《嫉妒》的隐藏艺术

罗布·格里耶的小说《嫉妒》隐藏了许多内容,不仅隐藏了中心人物,还隐藏了最核心的情节,这些都是由小说的叙事方式,由叙述者观察的位置和角度决定的.罗布·格里耶可能要告诉读者:所谓的真实、真相是不存在的,是无法弄清的,不存在传统小说中所谓的真实.     

关于网络教材设计的几点思考

随着现代教育技术的发展与普及，教材设计也开始突破传统模式，与网络、多媒体等技术结合起来。章对网络教材的设计思想、设计原则以及在设计过程中应考虑的一些因素做了分析和讨论，同时，也对网络教材的开发提出了自己的看法和具体的步骤。     

新课改背景下的中学地理"课堂讨论法"

构建开放式地理课程是《全日制义务教育地理课程标准》的一个基本理念,是新课程改革的要求,中学地理课堂讨论的教学方法与野外调查法和多媒体教学法相比,在形式、内容、时间等方面具有很大的优势:课堂讨论与学生的实际生活联系紧密,能让学生积极主动的学习,培养学生具有终身学习的能力及逐步形成正确的世界观、人生观和价值观。