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101.
J Kato Alice Abraham Ruram S Sekharjit Singh S Bilasini Devi Th Ibetombi Devi W Gyaneshwar Singh 《Indian journal of clinical biochemistry : IJCB》2007,22(1):128-130
The present, study was conducted to determine the level of malondialdehyde (MDA) as an index of free radial induced lipid
peroxidation and antioxidant vitamins-vitamins A, vitamin C and vitamin E in 75 confirmed cases of urolithiasis. Significantly
high level of MDA (p<0.001) with significantly low levels of vitamin E (p<0.001) and vitamin A (p<0.001) with no significant
decrease in vitamin C (p>0.05) were observed in the plasma of urolithiasis cases as compared to normal controls. In conclusion,
it appears that a role of lipid peroxidation and oxidative function exists in the pathogenesis of urolithiasis. But, the exact
mechanism how this occurs remains to be elucidated. 相似文献
102.
The high mobility group (HMG) proteins I and Y are well characterised non-histone chromosomal proteins which bind to A-T rich
regions of DNA and regulate gene expression and/or DNA replication. A correlation has been demonstrated between the increased
expression of HMG-Y proteins and malignancy. However, it is not known whether the expression of HMGs particularly, the Y group,
is a function of proliferation rate. In the present study, we have used normal tissues of calf testes, thymus and liver. The
results show distinctly high expression of HMG-Y proteins in testes than in thymus and the expression was practically undetectable
in liver. The results suggest that even in normal tissues there is a direct correlation between the proliferation rate and
the expression of the HMG-Y proteins, which can partly explain its increased expression in cancer. 相似文献
103.
Towards a research training curriculum: What, Why, How, Who? 总被引:3,自引:0,他引:3
Our purpose in this paper is to investigate the ways in which the work of research higher degree supervision is being reshaped from within and outside universities. Our interest is in the means by which new ‘content’ and ‘process’ knowledge — and thus a new set of pedagogical tasks and relationships — are being configured in the field of higher degree research. The outcomes of research training have traditionally been products of a one-on-one supervisory relationship, that is, academic apprentice-to-disciplinary mentor. This is especially the case in the fields of arts/humanities. Any ‘curriculum’ necessary to such a model has been both implicit and at the discretion of the disciplinary ‘master’. 相似文献
104.
Y. P. Singh O. P. Sachdeva S. K. Aggarwal K. Chugh Harbans Lal 《Indian journal of clinical biochemistry : IJCB》2008,23(3):290-292
Blood glutathione was estimated in fifty patients of head and neck cancer in the age group of 18–76 years and the results
were compared with a group of normal healthy controls. Mean blood glutathione level was found to be significantly lowered
in patients than the controls. Irrespective of the site, TNM classification, histopathology, and character of lesion, fall
in blood glutathione was nearly same in all the patients. The mean level was significantly increased after radiotherapy when
compared with the levels before radiotherapy. The decreased levels of GSH in-patients with head and neck cancer, observed
in the present study, may be due to its increased utilization by the cells. The results suggest that patients with head and
neck cancer have increased oxidative stress. 相似文献
105.
106.
Tiwari AK Mahdi AA Zahra F Chandyan S Srivastava VK Negi MP 《Indian journal of clinical biochemistry : IJCB》2010,25(4):411-418
The present study was conducted to investigate the oxidant–antioxidant status in iron deficient pregnant anemic women. One
hundred thirty pregnant women with iron deficiency anemia (IDA) were divided into three groups, namely mild (50), moderate
(50) and severe (30) anemic along with pregnant healthy women as controls (50). The complete blood count, plasma lipid peroxidation
products, enzymatic and non-enzymatic antioxidants were measured according to respective protocols. The levels of complete
blood count, iron, ferritin along with antioxidant enzymes namely catalase, superoxide dismutase, glutathione peroxidase,
glutathione reductase and reduced glutathione were significantly reduced in all IDA groups. However, the level of oxidized
glutathione, lipid peroxides, protein carbonyls, conjugated dienes were found significantly increased in all anemic patients.
Antioxidant vitamins, namely C, E and A were also found significantly decreased in IDA patients. On the basis of our results,
it may be concluded that IDA tends to increase the pro-oxidant components, which may result in various complications including
peroxidation of vital body molecules resulting in increased risk for pregnant women as well as fetus. 相似文献
107.
Yogesh M. Patel Sanidhya Jain Abhishek Kumar Singh Kedar Khare Sarita Ahlawat Supreet Singh Bahga 《Biomicrofluidics》2020,14(6)
We present design, characterization, and testing of an inexpensive, sheath-flow based microfluidic device for three-dimensional (3D) hydrodynamic focusing of cells in imaging flow cytometry. In contrast to other 3D sheathing devices, our device hydrodynamically focuses the cells in a single-file near the bottom wall of the microchannel that allows imaging cells with high magnification and low working distance objectives, without the need for small device dimensions. The relatively large dimensions of the microchannels enable easy fabrication using less-precise fabrication techniques, and the simplicity of the device design avoids the need for tedious alignment of various layers. We have characterized the performance of the device with 3D numerical simulations and validated these simulations with experiments of hydrodynamic focusing of a fluorescently dyed sample fluid. The simulations show that the width and the height of the 3D focused sample stream can be controlled independently by varying the heights of main and side channels of the device, and the flow rates of sample and sheath fluids. Based on simulations, we also provide useful guidelines for choosing the device dimensions and flow rates for focusing cells of a particular size. Thereafter, we demonstrate the applicability of our device for imaging a large number of RBCs using brightfield microscopy. We also discuss the choice of the region of interest and camera frame rate so as to image each cell individually in our device. The design of our microfluidic device makes it equally applicable for imaging cells of different sizes using various other imaging techniques such as phase-contrast and fluorescence microscopy. 相似文献
108.
Vasudha Shukla Manish Vashistha Som Nath Singh 《Indian journal of clinical biochemistry : IJCB》2009,24(1):70-75
Aqueous and alcoholic extracts of amalki (Emblica officinalis), spirulina and wheatgrass were prepared and analyzed for antioxidant
vitamin content (vitamin C and E), total phenolic compounds. Antioxidant status, reducing power and effect on glutathione
S-transferase (GST) activity were evaluated in vitro. Vitamin C content of crude amalaki powder was found to be 5.38 mg/g,
while very less amount 0.22 mg/g was detected in wheat grass. Amalki was rich in vitamin E like activity, total phenolic content,
reducing power and antioxidant activity. Total antioxidant activity of aqueous extract of amalki, spirulina and wheat grass
at 1mg/ml concentration were 7.78, 1.33 and 0.278 mmol/l respectively. At similar concentrations the total antioxidant activity
of alcoholic extract of amalaki, spirulina and wheat grass was 6.67, 1.73 and 0.380 mmol/l respectively. Amalki was also found
to be rich source of phenolic compounds (241mg/g gallic acid equivalent). Alcoholic extract of wheat grass showed 50 % inhibition
in FeCl2- ascorbic acid induced lipid peroxidation of rat liver homogenates in vitro. Both aqueous and alcoholic extracts of amalaki
inhibited activity of rat liver glutathione S-transferase (GST) in vitro in dose dependant manner. Since GST acts as powerful
drug metabolizing enzyme its inhibition by amalaki offers possibility of its use for lowering therapeutic dose of herbal preparations.
The aqueous extracts of both amalki and spirulina also showed protection against t-BOOH induced cytotoxicity and production
of ROS in cultured C6 glial cells. 相似文献
109.
Cynthia R. Chambers Michael L. Wehmeyer Yumiko Saito Kerry M. Lida Youngsun Lee Vandana Singh 《Exceptionality》2013,21(1):3-15
Abstract Promoting self-determination has become an important aspect of the educational programs of students with disabilities. There is now a sufficient literature base to support some syntheses that enable researchers to judge their progress in this area to date and to provide direction for future research and practice. For this study, we conducted a literature review of studies that measured or examined global self-determination. 相似文献
110.
Rajesh Kumar Kori Manish Kumar Singh Abhishek Kumar Jain Rajesh Singh Yadav 《Indian journal of clinical biochemistry : IJCB》2018,33(4):372-381
The problem of pesticides is not new and its exposure to human due to indiscriminate use is largely associated with the health related problems including neurotoxicological alterations. High levels of pesticide residues and their metabolites in the dietary constituents, food materials, maternal blood, cord blood, placenta breast milk have been reported and linked to alterations in birth weight, crown heel length, head circumference, mid-arm circumference and ponderal index of the neonates. Epidemiological studies have suggested that exposure of pesticide to human could be a significant risk factor for neurological disorders, including Parkinson’s disease, Alzheimer’s disease and multiple sclerosis. Cholinergic and non-cholinergic dysfunctions in pesticide exposed population, especially in children have also been frequently reported in recent years. Developmental neurotoxicity is another concern in the area where pregnant are more prone towards its exposure and which results in the abnormalities in the fetus. In view of the increasing risk of human health through pesticide exposure, the present review has been focused on the studies pertaining to pesticide induced neurochemical alterations and associated behavioral abnormalities in farm workers which could establish a possible link between the its exposure and associated health hazards. 相似文献