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Nychthemeral rhythmicity of urinary copper (Cu) was studied in 40 clinically healthy volunteers and 35 renal stone formers. A marked diurnal rhythm was noticed in urinary Cu levels in healthy subjects with maximum excretion at 0000 to 0600 hr followed by a progressive fall during the rest of the period reaching minimum between 1200 to 1800 hr in males and 0600 to 1200 hr in female volunteers. Similarly, all stone patients exhibited a definite rhythm in urinary Cu with significant amplitude and acrophases at 2145 hr for males and 2141 hr for female stone formers. However, there was no difference in mean 24-hr Cu excretion in male and female stone formers, whereas a significant change was observed in case of healthy subjects. Urinary Cu was found to be significantly increased in renal stone formers in comparison to healthy controls of either sex attributing a significant role of this overlooked trace mineral in the crystallization and/or activation of either of the process of stone formation in the renal tubules.  相似文献   
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Intelligent computer-assisted instructional systems have been constructed and applied within a wide range of fields. Very few of these systems make explicit a central or set of core learning theories or learning environments upon which a system is based. However, many of these systems have implicitly employed learning theories and environments. This paper looks at a variety of intelligent computer-assisted systems with a view towards uncovering the latent learning theories they employ. The interplay of the various learning theories needed to realise a student-initiated learning environment are discussed. The central features required for such an environment to function and the limitations of realising such a learning environment due to the state of the art of present day systems are also discussed. Specializations: physics education; computer education; intelligent computer-assisted instructional systems; physics problem solving. Specializations: chemical education, technology education, history and philosophy of science, learning theories.  相似文献   
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  总被引:1,自引:0,他引:1  
The United Nations Declarations of Human Rights (1948) express an ideal for the protection of cultural rights of everyone. They propose an education that is multicultural and non‐discriminatory and recognise that parents have the right to choose their children's education. Article 13.3 of the International covenant on Economic and Social and Cultural Rights gave parents the right to choose for their children “schools other than those established by public authorities to ensure the religious and moral education of their children in conformity with their own convictions”. The paper feels uneasy with this principle that grants parents the right to educate their children in conformity with their own convictions. Such rights could result in restricting the education of children to the narrow framework of parental beliefs and values that could be antithetical to social harmony, individual autonomy and equal opportunity. The question is, should such a right be extended to all parents including those who believe in racial superiority, in apartheid, Nazism or Fascism or in the inherent intellectual differences between boys and girls? The paper discusses some of these issues and asks how can the best interests of the child be served in a pluralist, multicultural, multiracial society. The paper acknowledges that in a pluralistic democratic society there will always be tensions between the public interests, the interests of the group and the interests or autonomy of the individual. These interests are discussed within the framework of fundamental human rights, common or separate schooling and multicultural education. The paper sees these as interrelated issues which are connected with group identity and equal opportunity. Where these interrelated issues conflict, the paper takes the stance that the rights and the autonomy of the individual should take precedence over the others, especially if the notion of human rights and human dignity is to be preserved in practice. This is obviously a controversial issue and the hope is that the paper will open up these issues for further discussion and debate.  相似文献   
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This paper seeks to extend the range of critical literacy strategies that environmental educators might use in their engagement with curriculum policies. The paper focuses on a recent curriculum and professional development project from Australia as the context to illuminate and explicate particular critical reading strategies. Specifically, the paper introduces several critical reading strategies by applying them to an evaluation of the Global Education Project's review of global perspectives in curriculum policies from around Australia.  相似文献   
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The Website is the trademark of the modern distance education (DE) system as DE is vastly dependent on the World Wide Web in delivering academic programs and student support services. DE authorities and administrators should make every effort to ensure that their Web interfaces are intuitive and easy to use for supplying “any time, any place” service. Unfortunately, we distance educators in Asia are far behind our Western counterparts in this aspect. This article explores the level of accessibility of Websites of members of the Asian Association of Open Universities (AAOU) in order to provide the results to the Asian DE authorities. The author's primary objectives in writing this article are to highlight the importance of Web accessibility for distance education institutions and their libraries in catering to a wide range of user groups and to point out how easily barrier-free Websites can be created if the basic rules of Web accessibility are followed.  相似文献   
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In the natural sciences, collecting, cataloguing, and comparing living specimens have long been a popular, collaborative mode of discovery and learning. New species are discovered, and the relationships between species are theorized. From Aristotle's “History of Animals” to Darwin's “On the Origin of Species”, and beyond, this process of learning through expedition has yielded bountiful knowledge and insights to students of science. In this paper, we propose that expeditionary learning can be applied to a softer science: the field of information systems. In the field of information systems, specimens (information systems) are created by humans, evolving with great speed. Expeditionary learning—where students collaboratively discover, catalog, and compare rapidly evolving information system specimens—is an innovative approach for learners in the IS field, and is effective in increasing IS program visibility and delivering significant, measurable community impact. Our results indicate that learning by expedition has a strong, positive community impact through educating external learners (such as high school and community college students, and the general public), and compares favorably to conventional experiential and service learning styles. Though expeditionary learning does not yield improved course evaluations, we demonstrate that learners’ perceived self‐knowledge and intentions to pursue the subject area are improved.  相似文献   
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The study has been undertaken as number of sickle cell patients in Chhattisgarh tribal population is 23.7 %. The Co enzyme Q10 is a strong antioxidant and energy producing compound. The patients were divided into three groups group A homozygous (SS), group B heterozygous (AS) and group C controls for TBARS study. The age group is 10–55 years and 200 mg of CoQ10 was given to A and B groups. The hematological parameters, C reactive protein as well as RBC TBARS level were performed by usual and standard techniques. The results were obtained as 25.37 % increased RBC level in group A and 23.24 % in group B. The increased hemoglobin level was observed as 16.73 % in group A and 10.7 % in group B. In case of WBC it was observed increased 24.38 % in group A and 12.0 % in group B. C-reactive protein was observed 7.8 times decreased in group A and 1.54 times in group B. The RBC TBARS level was also found decreased 48 % in group A and 51 % in group B as compared to group C. During the supplementation of coenzyme Q10 the pain caused by vaso-occlusive events has reduced. This significant increase in hematological parameters as well as decreased C-reactive protein and TBARS level suggest that the Q10 should be included in the diet of sickle cell patients.  相似文献   
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