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331.
There are interesting similarities between carcinomas of the breast and prostate. Both genetic and exogenous factors are probably important in the development of breast and prostate cancers. Since there is an alarming increasing trend in the incidence of both cancers worldwide including India, high level of apprehension/awareness has been created among the general educated population. Furthermore, both cancers are strongly linked with the expression of the c-erbB-2 oncogene which has been the focus of basic research in the recent past. This gene belongs to the family of growth factor receptors and it has important implication in diagnosis and future treatment modalities. 相似文献
332.
Senthilkumar Kamatchiammal Dhashinamoorthy Saravanakumar Nagalingeswaran Kumarasamy Sunithi Solomon Manjula Sritharan Venkataraman Sritharan 《Indian journal of clinical biochemistry : IJCB》2000,15(2):76-82
We have developed a simple, economical and reproducible method for processing blood samples from HIV infected patients for
diagnosis of tuberculosis. The procedure was validated on 55 samples selected for tuberculosis based on clinical criteria.
52 patients had radiological changes indicative of pulmonary tuberculosis of which only 28 were positive for AFB in sputum
(sensitivity 54%) and 27 for tuberculin (sensitivity 52%). 26 HIV positive patients who showed positive X-ray did not react
to tuberculin. The genus PCR probe missed 3 samples (sensitivity 94%) compared to X-ray.M.tuberculosis was detected in the blood of all X-ray positive cases by PCR using TB400 probe (sensitivity 100%) and another probe forM. tuberculosis, IS6110, missed 6 of them (sensitivity 88% compared to X-ray and 89% compared to TB400). It is proposed that this simple
sample processing method could be used to screen all blood samples quickly for mycobacteremia using the genus PCR and only
those positive for mycobacteria need to be tested forM.tuberculosis. This would save the scarce resources and time by reducing significantly the number of samples to be screened for species
confirmation. 相似文献
333.
Namrata Sharma 《Journal of Intercultural Communication Research》2019,48(3):274-291
The aim of this study was to analyse how cultural intelligence (CQ) influences the acculturation process and adaptive outcomes of a physiognomic minority indigenous cultural group in India. This study (N = 246) concerning the northeastern (NE) Indian diaspora in Indian cities outside the NE region. Path analysis showed that integration and assimilation predicted higher adaptation; while marginalization and separation lowered adaptation. Likewise, CQ positively predicted adaptation and also moderated the relationship between acculturation strategies and adaptation. Therefore, findings reflect the flexible facilitative role of CQ in promoting adaptation of minority groups in acculturation context. 相似文献
334.
Namrata Sharma 《Journal of Intercultural Communication Research》2017,46(1):96-110
The concept of cultural intelligence was formulated to ease and understand multicultural interactions in business organizations. Based on the theory of multiple intelligence; it is the cross-cultural facet of intelligence that assists adaptive cultural adjustment. Due to its implications for the contemporary world witnessing increased cultural contact and clashes; it has attracted multidisciplinary scholarly interest. This article reviews the development, validation and major approaches to the construct, along with a focus on its critical analysis. Significance of the construct in promoting intercultural discourse to encourage pacific multicultural existence is implicated. Furthermore, suggestions are made to extend the scope of cultural intelligence research and integrate it in diverse fields encompassing intercultural contact and communication. 相似文献
335.
Devendra K. Rai Prashant Kumar Rai Aradhna Gupta Geeta Watal Bechan Sharma 《Indian journal of clinical biochemistry : IJCB》2009,24(2):198-201
Wistar rats of 6–8 weeks in age weighing between 120–150 g were exposed to the fixed doses of each of the carbamate pesticides
such as cartap (50% LD50) and carbofuran (50% LD50) as well as a combination of these two with 25% LD50 of each for one week. The effect of treatments was studied in terms of serum lipid parameters such as high-density lipoprotein,
total cholesterol, triglyceride, low-density lipoprotein and very low-density lipoprotein. Treatment with individual doses
of carbofuran (50% LD50) and cartap (50 % LD50) caused significant alterations in the levels of serum lipid parameters. The pesticides treatment resulted in marked decrease
in the level of serum high-density lipoprotein where as that of other lipids got significantly elevated. Further, the rats
exhibited relatively higher impact of pesticides when treated with the compounds in combination (25 % LD50 of each). The results indicated that these compounds when used together may exert enhanced effect on the levels of serum
lipids in rat. 相似文献
336.
D. C. Sharma Bhawani Kochar Ankita Bhardwaj Manminder Riyat Praveen Sharma 《Indian journal of clinical biochemistry : IJCB》2009,24(3):245-249
In order to scientifically evaluate the effect of copper bhasm, it was orally administered in a dose of 2 mg/day for seven
days to one month old male chicks. There was significant fall in total red cells, and rise in plasma iron, PCV and MCV indicating
hemolysis, compensated by increased heme synthesis. A significant increase in plasma iron binding capacity points to beneficial
effect of copper bhasm on liver as transferrin is synthesized in liver. Ferritin (storage iron) was unaltered in seven days
treatment. The effect of copper bhasm on tissue distribution of essential elements was variable. Calcium, sodium and potassium
were significantly increased in all the tissues. The last two may have been contributed by the bhasm itself. Magnesium behaviour
was similar to calcium. Iron and zinc showed variable effects. Copper level in whole blood, plasma and erythrocytes increased
significantly showing that copper bhasm was well absorbed and the effect observed can be ascribed to it. The bhasm was well
tolerated and no growth retardation was seen. 相似文献
337.
338.
microRNAs (miRNAs) are evolutionarily conserved small noncoding RNAs, also known as micromanagers of gene expression. Polymorphisms
in the miRNA pathway (miR-polymorphisms) are emerging as powerful tools to study the biology of a disease and have the potential
to be used in disease prognosis and diagnosis. Advancements in the miRNA field also indicate a clear involvement of deregulated
miRNA gene signatures in cancers, and several polymorphisms in pre-miRNA, miRNA binding sites or targets have been found to
be associated with various cancers. The miRNA polymorphisms have also been reported to influence tumor aggressiveness as well
as survival of cancer patients. miRNAs have a revolutionary impact on cancer research over recent years. They emerge as important
players in tumorigenesis, leading to a paradigm shift in oncology. The extensive and comprehensive use of miRNA microarrays
has enabled the identification of a number of miRNAs as potential biomarkers for cancer. Many miRNAs have been identified
to act as oncogenes, tumor suppressors, or even modulators of cancer stem cells and metastasis. Some studies not only reported
the identified miRNA biomarkers, but also deciphered their target genes and the underlying mechanisms. The rapid discovery
of many miRNA targets and their relevant pathways has contributed to the development of miRNA-based therapeutics. 相似文献
339.
Anjali Sharma Simmi Kharb Vineeta Nirmal Gulati 《Indian journal of clinical biochemistry : IJCB》1998,13(2):123-125
The present study revealed significantly lower levels of serum magnesium in patients with preterm labour without any apparent
cause as compared to normal term pregnant women in labour. The values were also lower in women with low socioeconomic status,
older age and consuming vegetarian diet. Hence, estimation of serum magnesium levels in pregnancy may be a useful parameter
in preterm labour. 相似文献
340.