Biomedical text summarization to support genetic database curation: using Semantic MEDLINE to create a secondary database of genetic information

Objective:

This paper examines the development and evaluation of an automatic summarization system in the domain of molecular genetics. The system is a potential component of an advanced biomedical information management application called Semantic MEDLINE and could assist librarians in developing secondary databases of genetic information extracted from the primary literature.

Methods:

An existing summarization system was modified for identifying biomedical text relevant to the genetic etiology of disease. The summarization system was evaluated on the task of identifying data describing genes associated with bladder cancer in MEDLINE citations. A gold standard was produced using records from Genetics Home Reference and Online Mendelian Inheritance in Man. Genes in text found by the system were compared to the gold standard. Recall, precision, and F-measure were calculated.

Results:

The system achieved recall of 46%, and precision of 88% (F-measure = 0.61) by taking Gene References into Function (GeneRIFs) into account.

Conclusion:

The new summarization schema for genetic etiology has potential as a component in Semantic MEDLINE to support the work of data curators.

Highlights

• Semantic MEDLINE streamlines information retrieval by succinctly expressing the meaning of sometimes complicated text and summarizing output according to a user''s needs.
• Semantic MEDLINE identifies genes noted in biomedical text as associated with a disease process.
• Semantic MEDLINE can potentially simplify secondary database curation.

Implications

• Library information retrieval services can potentially benefit from automated applications such as Semantic MEDLINE.
• Use of such automated applications can facilitate the library''s work in interdepartmental collaborative endeavors, thus reinforcing the library''s core value in its parent institution.

     

The geometric curvature of the spine during the sirshasana,the yoga’s headstand

This study analysed the behaviour of the geometric curvature of the spine during sirshasana. The position of dorsal retroreflective markers was computed via stereophotogrammetric analysis in six males and five females (29.4 ± 8.8 years, 63.0 ± 11.4 kg, 1.66 ± 0.08 m [average ± standard deviation]). The spinal points were projected onto the sagittal and frontal planes of the trunk, a polynomial was fitted to the data and the two-dimensional geometric curvature was quantified. The inferior lumbar lordosis decreased compared to the orthostatic position and gait, which may favour the posterior protrusion of the lumbar spinal nucleus pulposus in people with posterior herniation. The lateral deviation at the middle of the thoracic spine increases during sirshasana, which may reflect increased difficulties for postural control and spinal loads. It could be useful for promoting positive spinal structural and functional chronic adaptations for healthy participants, if the yoga programme is carefully planned and the spinal alignment is carefully monitored during a headstand. However, it may aggravate some spinal diseases, especially scoliosis.     

Identifying the information management process and knowledge creation in technology-based companies: a Brazilian comparative case study

Knowledge Management Research & Practice - Information and knowledge have been cited over the last two decades as competitive advantage tools. Recently, the use of them has been discussed to...     

Signal constellations in the hyperbolic plane: A proposal for new communication systems

Signal constellations in the hyperbolic plane are provided as an alternative to traditional signal constellations in the Euclidean plane, since channels may actually exist for which the latter signal constellations are not as suitable as the former. A hyperbolic gaussian probability density function, based solely on geometrical considerations, is derived to determine the performance of the hyperbolic signal constellations. Benefits result from an approach conceived in terms of reduced signal-to-noise ratio, needed to achieve a prescribed error rate and equivalent optimum receiver complexity.     

Triangulating Perspectives: A Needs Assessment to Develop an Outreach Program for Vulnerable and Underserved Populations

This article describes the tiered process used to conduct a needs assessment and the implications of the methods employed had on the design and development of interventions for a community audience. A needs assessment was conducted to identify health needs for an underserved, vulnerable population. This report emphasizes the findings addressing the need for preventative educational materials and programming. Ethnographic characteristics were used to gather information from multiple sample sources in order to triangulate data from three different perspectives: (1) the client, (2) providers and support staff, and (3) educators in the community. The outcomes of this project will serve as input for designing and implementing innovative educational outreach programs for the vulnerable and underserved populations and for community‐based physicians and medical students who serve the community.     

Conception, development and implementation of an e-Government maturity model in public agencies

Governments worldwide are encouraging public agencies to join e-Government initiatives in order to provide better services to their citizens and businesses; hence, methods of evaluating the readiness of individual public agencies to execute specific e-Government programs and directives are a key ingredient in the successful expansion of e-Government. To satisfy this need, a model called the eGovernment Maturity Model (eGov-MM) was developed, integrating the assessment of technological, organizational, operational, and human capital capabilities, under a multi-dimensional, holistic, and evolutionary approach. The model is strongly supported by international best practices, and provides tuning mechanisms to enable its alignment with nation-wide directives on e-Government. This article describes how the model was conceived, designed, developed, field tested by expert public officials from several government agencies, and finally applied to a selection of 30 public agencies in Chile, generating the first formal measurements, assessments, and rankings of their readiness for e-Government. The implementation of the model also provided several recommendations to policymakers at the national and agency levels.     

Introduction to the special section: life design interventions (counseling,guidance, education) for decent work and sustainable development

International Journal for Educational and Vocational Guidance -     

Interplay between childhood maltreatment, parental bonding, and gender effects: impact on quality of life

OBJECTIVE: The aim of this study was to examine associations between childhood adversity, parental bonding, gender, depressive symptoms, and quality of life in non-treatment-seeking adults from the community. METHOD: Effects of differential parental rearing were compared in adults who reported a high degree of childhood maltreatment (n=72) and those who reported no significant adverse events in childhood (n=69). Subjects completed retrospective measures of childhood maltreatment and perceived parenting style, as well as measures of current depressive symptoms and quality of life. RESULTS: The subjects without childhood maltreatment were younger and endorsed less current depressive symptomatology than did subjects with childhood maltreatment. While the subjects without a history of maltreatment reported more "optimal" bonding experiences with their parents, the maltreatment group members were more likely to characterize their early parental bonding experiences in terms of "affectionless control" (p<.001 for both maternal and paternal parenting), "affectionate constraint" (p=.025 for maternal parenting and p=.004 for paternal parenting), or "weak or absent" bonding (p<.001 for both maternal and paternal parenting). Results of a multiple regression analysis revealed that overall quality of paternal care (p=.015) and current level of depressive symptoms (p<.001) were significant independent predictors of adult quality of life. Gender effects between subjects providing parental bonding data were limited to the group with childhood maltreatment. CONCLUSION: These findings extend previous work documenting a relationship between early life maltreatment and suboptimal parental bonding, suggesting gender-specific effects of maternal and paternal care. Effects of childhood maltreatment on quality of life in adulthood appear to be linked with the quality of childhood paternal care and the occurrence of depressive symptomatology in adulthood, suggesting possible targets for primary or secondary prevention.