Spontaneous Tumor Lysis Syndrome in an Infant: A Case Report

Tumor lysis syndrome has been observed in patients with malignancies with high cellular burden and high cell turnover, tumor sensitive to therapy, especially after initiating medical treatment. It very rarely occurs spontaneously. The case described here is of 6 months male infant who presented with fever since 1 month and loose stools associated with blood since 15 days. The laboratory investigations showed lactate dehydrogenase (LDH) of 6,192 IU/L and serum uric acid 18.2 mg/dl along with pancytopenia. The infant presented with electrolyte abnormalities and renal failure.     

The promise of post‐publication peer review: how do we get there from here?

• Post‐publication peer review (PPPR) has not achieved its promise and potential.
• Few articles receive PPPR – even those in high‐profile journals.
• PPPR is difficult to find and needs to be linked to the original article.
• Academics require recognition if they are to contribute their time to PPPR.
• Improving PPPR would improve the scholarly corpus.

     

Impact of age on haematological markers pre- and post-marathon running

This study investigated whether haematological markers differ between young and masters marathon participants, running at similar performance levels. Nine young (31.89 ± 4.96 years) and eight masters (63.13 ± 4.61 years) runners participated. At five time points (pre-race through 54 h post-race), a complete blood cell count, basic metabolic panel and creatine kinase (CK) isoenzyme panel were assessed. Race performance was standardised using the World Masters Association Age Grading Performance Tables. Total CK levels were elevated for all participants at all time points post-race (P < 0.001). The CK-isoenzyme MB% was elevated across groups at 6, 30 and 54 h post-race (P < 0.01, P < 0.01 and P < 0.05), with masters runners having a higher CK-MB% at 30 and 54 h (P < 0.05, P < 0.05). Total white blood cell and neutrophil counts were elevated through 6 h post-race (P < 0.001), with higher levels found in younger runners (P < 0.001). When considering all blood work, masters runners had a higher number of abnormal values at 6, 30 and 54 h post-race (P < 0.05, P < 0.01 and P < 0.05). In conclusion, masters runners demonstrated sustained CK-MB elevation, which may suggest greater cardiac stress. However, future studies using additional cardiac markers should be completed to confirm these findings. In addition, masters runners showed an increased number of laboratory values outside normal range, indicating the body’s reduced capacity to respond to marathon running.     

Osmotically driven drug delivery through remote-controlled magnetic nanocomposite membranes

Implantable drug delivery systems can provide long-term reliability, controllability, and biocompatibility, and have been used in many applications, including cancer pain and non-malignant pain treatment. However, many of the available systems are limited to zero-order, inconsistent, or single burst event drug release. To address these limitations, we demonstrate prototypes of a remotely operated drug delivery device that offers controllability of drug release profiles, using osmotic pumping as a pressure source and magnetically triggered membranes as switchable on-demand valves. The membranes are made of either ethyl cellulose, or the proposed stronger cellulose acetate polymer, mixed with thermosensitive poly(N-isopropylacrylamide) hydrogel and superparamagnetic iron oxide particles. The prototype devices'' drug diffusion rates are on the order of 0.5–2 μg/h for higher release rate designs, and 12–40 ng/h for lower release rates, with maximum release ratios of 4.2 and 3.2, respectively. The devices exhibit increased drug delivery rates with higher osmotic pumping rates or with magnetically increased membrane porosity. Furthermore, by vapor deposition of a cyanoacrylate layer, a drastic reduction of the drug delivery rate from micrograms down to tens of nanograms per hour is achieved. By utilizing magnetic membranes as the valve-control mechanism, triggered remotely by means of induction heating, the demonstrated drug delivery devices benefit from having the power source external to the system, eliminating the need for a battery. These designs multiply the potential approaches towards increasing the on-demand controllability and customizability of drug delivery profiles in the expanding field of implantable drug delivery systems, with the future possibility of remotely controlling the pressure source.     

Pivoting: leveraging opportunities in a turbulent health care environment

Purpose:

The purpose of this lecture is to challenge librarians in clinical settings to leverage the opportunities presented by the current health care environment and to develop collaborative relationships with health care practitioners to provide relevant services.

Discussion:

Health care organizations are under financial and regulatory pressures, and many hospital librarians have been downsized or have had their positions eliminated. The lecture briefly reviews hospital librarians'' roles in the past but focuses primarily on our current challenges. This environment requires librarians to be opportunity focused and pivot to a new vision that directs their actions. Many librarians are already doing this, and colleagues are encouraging us to embrace these opportunities. Evidence from publications, websites, discussion lists, personal communications, and the author''s experience is explored.

Conclusion:

Developing interdisciplinary and collaborative relationships in our institutions and providing relevant services will mark our progress as vital, contributing members of our health care organizations.     

Archipelagic rhetoric: remapping the Marianas and challenging militarization from “A Stirring Place”

Engaging critical rhetorical fieldwork in the Mariana Islands archipelago, this article destabilizes colonial naming projects and US federal control that dispossess island places from Indigenous peoples. On Euro-American and military maps, archipelagoes are depicted as distant, tiny, empty, or merely (is)lands for US geostrategic control. I argue for a remapping of the Marianas as expansive, oceanic sites of resistance to colonial cartographic violence and US militarization. Fieldwork in the Marianas demonstrates how Indigenous epistemologies function as archipelagic rhetoric enacted through a Chamoru sense of place. I examine these fluid relational connections to place and their implications for decolonization.     

Informational Sources,Social Media Use,and Race in the Flint,Michigan, Water Crisis

Safe, clean water is necessary for health and well-being. Water issues affect minority and vulnerable populations at disproportionate rates, including the poor and racial and ethnic minorities. An investigation of the relationships of race, social media use, and informational sources during the municipal water crisis in Flint, Michigan, reflects an instrumental view of communication and uses and gratifications theory in this study. Data from 208 Flint residents in 2016 indicated that African American respondents favored interpersonal networks and resources and were more likely than other racial groups to obtain current information about the water crisis via Instagram. Preferred channels and sources to receive additional crisis information varied on the basis of race.     

Framing Refuge: Media,Framing, and Sanctuary Cities

The refugee sanctuary movement in the United States has shifted to include undocumented immigrants fleeing violence and economic strife. Given the negative tenor of coverage of undocumented immigration, and ties between framing and policy views on immigration, how the media frames sanctuary cities is likely to impact public perceptions of these cities and their policies. To assess media coverage of sanctuary policies, we analyzed articles from five national newspapers from 1980 to 2017 with both human content analysis and dictionary-based computational analysis. We find that framing around religion/morality and conflict has decreased, while stories focusing on crime and partisanship have increased. We discuss implications for public opinion and the likelihood that the American public will take their cues from media framing and elite discourse when it comes to sanctuary policies.     

父母外出务工与留守子女辍学——基于CHNS调查数据的经验分析

利用中国健康与营养调查(CHNS)数据,本研究对农村父母外出务工与留守子女初、高中阶段辍学行为之间的关系进行了实证分析。结果表明:父亲外出务工会显著降低留守子女初、高中阶段的辍学概率,母亲外出务工则会显著增加留守子女初中阶段的辍学概率。此外,免费义务教育政策的实施在较大程度上降低了留守子女的初、高中阶段的辍学概率;与那些父母受教育程度较低的留守子女相比,父母受教育程度越高的留守子女越不容易辍学;家庭子女数和机会成本会提高留守子女初中阶段辍学的概率。因此,为降低农村中学阶段子女辍学率,政府应当增加农村妇女当地就业机会以减少母亲外出的影响、推进户籍制度改革使随迁子女能获得同等的教育机会,并为高中阶段和多子女家庭提供教育补贴。     

体育学院优秀散打运动队管理现状研究

本文采用文献资料法、问卷调查法、访谈法、数理统计法对我国体育院校优秀散打运动队的基本情况和运动员在思想、学习、训练以及生活管理中的现状进行分析探讨,希望能及时解决管理中存在的问题,从而为进一步提高我国散打运动队的管理提供服务。