在研药物关联专利的判别指标

日本版NIH及其制药企业,政策制定·战略规划需要佐证。本研究尝试基于新的指标体系对制药行业现状进行俯瞰与预测未来。连载第四篇,为了基于专利把握医药品产业的基础研究能力,定位与制药企业各个研发项目的进展状况【临床前实验】→【Ⅰ期临床试验】→【Ⅱ期临床试验】→【Ⅲ期临床试验】→【批准申请】→【批准】→【上市】密切相关的专利,尝试导出其新型指标。明确了作为指标,IPC分类、被引专利数、专利引用非专利文献数有效。基于专利的这些新指标,不但是通过在研药物（pipeline）,也可以通过专利把握医药品产业新药创出力以及未来新药的创出力。     

A positive psychological viewpoint for success at school – 10 characteristic strengths of the Finnish high-achieving students

People who exploit their strengths flourish; they are not only engaged with their goals, but also to their well-being and the content of life. In this study, interest focused on the high-achieving students in the Finnish general upper secondary education, in other words, on straight-A graduates’ characteristic strengths. This was a narrative study in which the data were obtained through written narratives and narrative interviews among 14 Finnish straight-A graduates. The data were analyzed with narrative analyzing methods. Ten typical strengths found and further categorized into three key dimensions were: (1) the thirst of knowledge and passion for learning, (2) fortitude and authenticity, and (3) love. This study implied that the youth’s school paths and well-being actively increased their own characteristic strengths.     

A neurodevelopmental profile of the rural hearing‐impaired child in the QwaQwa region,South Africa

Being hearing impaired does not only affect a child's academic performance, but can also influence a child's overall development and ability to succeed academically. Children with hearing impairment often experience delays in other areas of their development and an understanding of the inter‐relatedness of these delays are important in order to address all these aspects, and thus minimise the impact on a child's overall development. The paper provides a neurodevelopmental profile of 4‐year‐old to 8‐year‐old rural hearing‐impaired children based on the result of a psychometric assessment. Eighteen children were selected from a special needs school in the rural QwaQwa Free State area of South Africa and underwent a psychometric assessment using two test batteries (Griffiths mental developmental scales – extended revised and a neurodevelopmental evaluation scale). The neurodevelopmental profile will contribute to knowledge of the nature of the challenges faced by the hearing‐impaired child in rural education and the neurodevelopmental origin of these challenges.     

Validation of the Early Childhood Ecology Scale-Revised: A Reflective Tool for Teacher Candidates

Given increasing numbers of young culturally and/or linguistically diverse (CLD) children across the United States, it is crucial to prepare early childhood teachers to create high-quality environments that facilitate the development of all children. The Early Childhood Ecology Scale-Revised (ECES-R) has been developed as a reflective tool to help early childhood teacher candidates examine their beliefs concerning classroom ecology. Using cultural responsivity and classroom management theories as the theoretical framework, the authors posit that the ECES-R identifies five dimensions that promote a high-quality, culturally responsive classroom ecology. These include the sociocognitive, sociocultural, sociolinguistic, socioemotional, and sociophysical dimensions. Evidence for reliability and validity was established. Factor analysis supported the five proposed dimensions, with the identification of an additional dimension: sociocomfort.     

Measuring the Interactive Skills of Caregivers in Child Care Centers: Development and Validation of the Caregiver Interaction Profile Scales

Research Findings: High-quality caregiver–child interactions constitute the core of high-quality child care for young children. This article describes the background and development of the Caregiver Interaction Profile (CIP) scales to rate 6 key skills of caregivers for interacting with 0- to 4-year-old children in child care centers: sensitive responsiveness, respect for autonomy, structuring and limit setting, verbal communication, developmental stimulation, and fostering positive peer interactions. Each interactive skill is rated on a 7-point scale based on observation of video-recorded caregiver–child interactions. Together, the 6 scale scores constitute an Interaction Profile for individual caregivers that may serve as a starting point for education and training to improve the quality of caregiver–child interactions. This article also presents the results of a 1st study with the CIP scales, in a sample of 145 caregivers from 75 child care groups in 47 child care centers in The Netherlands. Practice or Policy: Results provide promising preliminary evidence supporting the reliability and validity of the CIP scales.     

Meta-concepts,thinking skills and religious education

This paper proposes that the acquisition of meta-concepts and thinking skills in order to facilitate scholarly religious thought should be the principal aim of religious education in schools. As a result, the aim of religious education is primarily stated in cognitive terms and religious education is understood as closely related to education about religion. The educational value of this approach is explained in a cultural–historical perspective on learning. It is shown that there is a close connection between learning and development and that school learning especially contributes to development of pupils’ higher cognitive functions, if school learning aims at the acquisition of subject-specific meta-concepts and thinking skills. In order to apply these insights to religious education, the aim of religious education is reconsidered and some examples of meta-concepts and thinking skills that may serve as the content of religious education are discussed.     

Preschoolers' Funds of Knowledge Displayed Through Sociodramatic Play Episodes in a Bilingual Classroom

Funds of knowledge displayed by young children during sociodramatic play in a two-way bilingual preschool classroom are identified. Twelve preschoolers participated in a microethnographic study of children's language and culture in a small rural community of South Texas. The study sought to identify cultural elements or traits of Mexican American children exhibited during sociodramatic play. The cultural traits identified as funds of knowledge include language, values and beliefs, ways of discipline, and the value of education, among others. It is suggested for teachers to use sociodramatic play as a tool to observe children and learn about their funds of knowledge in order to implement a culturally reflective curriculum.