Increased plasma vaspin concentration in patients with sepsis: an exploratory examination

Introduction

Vaspin (visceral adipose tissue-derived serpin) was first described as an insulin-sensitizing adipose tissue hormone. Recently its anti-inflammatory function has been demonstrated. Since no appropriate data is available yet, we sought to investigate the plasma concentrations of vaspin in sepsis.

Materials and methods

57 patients in intensive care, fulfilling the ACCP/SCCM criteria for sepsis, were prospectively included in our exploratory study. The control group consisted of 48 critically ill patients, receiving intensive care after trauma or major surgery. Patients were matched by age, sex, weight and existence of diabetes before statistical analysis. Blood samples were collected on the day of diagnosis. Vaspin plasma concentrations were measured using a commercially available enzyme-linked immunosorbent assay.

Results

Vaspin concentrations were significantly higher in septic patients compared to the control group (0.3 (0.1-0.4) ng/mL vs. 0.1 (0.0-0.3) ng/mL, respectively; P < 0.001). Vaspin concentration showed weak positive correlation with concentration of C-reactive protein (CRP) (r = 0.31, P = 0.002) as well as with SAPS II (r = 0.34, P = 0.002) and maximum of SOFA (r = 0.39, P < 0.001) scoring systems, as tested for the overall study population.

Conclusion

In the sepsis group, vaspin plasma concentration was about three-fold as high as in the median surgical control group. We demonstrated a weak positive correlation between vaspin and CRP concentration, as well as with two scoring systems commonly used in intensive care settings. Although there seems to be some connection between vaspin and inflammation, its role in human sepsis needs to be evaluated further.Key words: adipocytokine, inflammation, vaspin, CRP, intensive care     

Microfluidic assessment of swimming media for motility-based sperm selection

Selection medium is important in sperm isolation for assisted reproductive technologies. Contrary to the naturally occurring human cervical mucus which has a high viscosity, most current practices for motility based sperm selection use a low viscosity medium. In this study, we used a microfluidic device to assess the effects of high viscosity media made with hyaluronic acid (HA) and methyl cellulose (MC) on bovine and human sperm motility and viability (sperm transferred directly from cryoprotectant). The microfluidic penetration test, viability, and motility were compared for sperm swimming in both HA and MC media with about 20cp viscosity (measured at 20 °C). Our resulted indicate that MC medium resulted in a significantly higher number of viable bovine sperm penetrating the medium as compared to HA. Furthermore, MC resulted in the selection of a sperm subpopulation with a 274% increase in sperm viability in comparison to the raw semen, while HA increased viability by only 133%. In addition to viability, bovine sperm motility parameters were significantly higher in the MC medium as compared with HA. Experiments with human sperm swimming in MC indicate that sperm swim slower and straighter at higher viscosities. In conclusion, the results indicate that in a micro-confined environment representative of the in vivo environment, MC is a preferred high viscosity medium to ensure the highest concentration of motile and viable sperm.     

Interactive Kiosk at the Texas Tech University Libraries

The academic library, given its often privileged position on campus, is the information source that can include directional as well as general campus facts among the myriad of print and e-resources for reference. Also, an academic library's audiences can be quite varied and include prospective students or parents seeking more general knowledge of the building and the campus. Many times this need for information drives patrons to the library service desks. Sometimes, especially during the high-demand seasons of new student orientation and beginning of the fall semesters, the desk is so busy that many patrons will leave because they don't have the time to wait. To address this immediate need for information, Texas Tech University Libraries developed an interactive kiosk to provide general information for frequently asked questions in a more efficient, creative, and interactive way. The kiosk provides a fun method of satisfying a patron's information needs without the requirement of a staff member or the need to wait in line for help. The kiosk is available as long as the Library is open and provides a variety of useful answers to general questions, as well as facts about the Library.     

Transforming education systems: comparative and critical perspectives on school leadership

The centrality of education in the pursuit of better economic and social prosperity is now well established. The dominance of human capital theory, which provides a strong argument for better education as a key factor in fuelling economic growth, has encouraged policy makers, in various countries, to focus on education reform as a key priority and to borrow policy solutions from other countries. This special edition explores one policy solution in depth. It investigates the preparation and training of school leaders in very different countries and takes a comparative perspective. This article argues that the limitations of standardized strategies are clearly visible when taking a comparative view and, most importantly, that context matters significantly in shaping, defining and explaining differential educational performance.     

Comparing performance: a cross-national investigation into the teaching of mathematics in primary classrooms in England and China

This article presents initial findings from an empirical study of the effectiveness of mathematics teaching (EMT). The article explores the teaching of mathematics in two very different contexts: England and China. Within each country, the target cohort of pupils were those aged 9–10 and overall, 19 teachers, 10 from England and nine from China, participated in the study together with their pupils (n = 562). Two internationally validated instruments were used to collect the data and teacher behaviours were also measured systematically. In addition, structured observation was undertaken in classrooms in both countries. The results show that, on average, Chinese teachers scored higher on effective teaching measures and Chinese pupils outscored their English peers in the tests that were part of the study. This research project is currently collecting qualitative data but its findings, to date, reinforce the findings from previous research studies suggesting that certain teacher behaviours and classroom factors work effectively to improve student learning outcomes.     

Multimodality in the Technical Communication Classroom: Viewing Classical Rhetoric Through a 21st Century Lens

The authors provide a robust framework for using rhetorical foundations to teach multimodality in technical communication, describing a pedagogical approach wherein students consider the rhetorical canons—invention, arrangement, style, delivery, and memory—when developing texts beyond print. Students learn to assess their own work, reflecting on how each canon contributed to the rhetorical effectiveness of their multimodal projects. The authors argue for using the canons as a rhetorical foundation for helping students understand technical communication in the digital age.     

Environmental identity,pro-environmental behaviors,and civic engagement of volunteer stewards in Portland area parks

We conducted surveys of adults participating in municipally sponsored volunteer events in the Portland, OR metropolitan area in order to understand the range of attitudes and behaviors associated with volunteer work. We sampled 172 individuals in 18 events from February to June 2012. Principal components and factor analyses of survey responses identified three groups based on annual frequency of participation in stewardship events: first-time volunteers, mid-level volunteers (3–10 events per year), and frequent volunteers (>10 events per year). Our analyses revealed three main factors that explained the variation in survey response for the three volunteer groups: environmental identity, private pro-environmental behavior, and civic engagement. All three factors were positively correlated with frequency of participation in stewardship events, with the most frequent volunteers indicating the highest degree of attention to environmental issues, environmental identity, and self-reported pro-environmental behaviors. Frequent volunteers were more likely to feel personally attached to their local environment, believe that their efforts help solve environmental problems, and enjoy being part of community efforts. These results suggest that stewardship activities provide opportunities for volunteers to interact with others while working collectively toward restoring and maintaining parks, which may contribute to more resilient communities.