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51.
    

Introduction

Vaspin (visceral adipose tissue-derived serpin) was first described as an insulin-sensitizing adipose tissue hormone. Recently its anti-inflammatory function has been demonstrated. Since no appropriate data is available yet, we sought to investigate the plasma concentrations of vaspin in sepsis.

Materials and methods

57 patients in intensive care, fulfilling the ACCP/SCCM criteria for sepsis, were prospectively included in our exploratory study. The control group consisted of 48 critically ill patients, receiving intensive care after trauma or major surgery. Patients were matched by age, sex, weight and existence of diabetes before statistical analysis. Blood samples were collected on the day of diagnosis. Vaspin plasma concentrations were measured using a commercially available enzyme-linked immunosorbent assay.

Results

Vaspin concentrations were significantly higher in septic patients compared to the control group (0.3 (0.1-0.4) ng/mL vs. 0.1 (0.0-0.3) ng/mL, respectively; P < 0.001). Vaspin concentration showed weak positive correlation with concentration of C-reactive protein (CRP) (r = 0.31, P = 0.002) as well as with SAPS II (r = 0.34, P = 0.002) and maximum of SOFA (r = 0.39, P < 0.001) scoring systems, as tested for the overall study population.

Conclusion

In the sepsis group, vaspin plasma concentration was about three-fold as high as in the median surgical control group. We demonstrated a weak positive correlation between vaspin and CRP concentration, as well as with two scoring systems commonly used in intensive care settings. Although there seems to be some connection between vaspin and inflammation, its role in human sepsis needs to be evaluated further.Key words: adipocytokine, inflammation, vaspin, CRP, intensive care  相似文献   
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A series of light-fastness tests were conducted on a group of ethnographic objects that will be on exhibit at the Smithsonian Institution Arctic Studies Center, a recent addition to the Anchorage Museum at Rasmuson Center in Alaska. The objects surveyed belong to the collections of the Smithsonian National Museum of Natural History and the Smithsonian National Museum of the American Indian. This work was designed as a feasibility study on the use of a micro-fading tester as a non-contact and non-destructive technique to evaluate the light-stability of materials present in ethnographic collections. A broad range of objects containing a wide variety of materials were selected for the study. The materials investigated included a variety of dyes applied on silk, cotton, and wool substrates along with some unusual materials such as tanned skin and seal gut skin. The results from this investigation have allowed establishing exhibition recommendations taking into consideration the sensitivity of each object, light levels in the museum building, and estimated light exposures based on the duration of the exhibit. The micro-fading tester has proven to be a very useful tool for determining the light-stability of ethnographic materials without causing any harm to the objects. Objects containing equivalent materials are usually classified under a general category based on their probable sensitivity to light. However, micro-fading test results have permitted the detection of dissimilarities among some of these objects, which could be associated to variations in prior fading histories, the quality of raw materials, and different preparation methods.  相似文献   
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During the 1960s and 1970s a number of family learning projects evolved, most of which focused on pre-schoolers and their parents. The goal of some of these programs was to provide enjoyable, structured experiences in which parents and their children learned together. Recently, a number of institutions have been sponsoring enrichment science classes or learning experiences for parents and older children. The study described here is based on a project funded by the National Science Foundation (DISE No. 07872) which was attempting to show that it was possible to increase scientific literacy of two different age groups by simultaneously exposing parents and their middle school children to short courses in science. The project is an outgrowth of a study previously reported (Gennaro, Bullock, & Alden, 1980) carried out at the Minnesota Zoological Gardens. The study is based on data obtained during the first two years of the project and used various data gathering procedures such as the use of questionnaires, interviews, observations, and cognitive testing. It was found that children register for the courses primarily because of interest in the subject matter of the courses and that parents register because of their desire to nurture the child and the child's interest in the subject matter of the course. Both parents and children made significant gains in learning as measured by subject matter tests. Participants reported that the experience was both enjoyable and valuable. Children's attitudes toward their parents and the course were significantly higher if the children perceived a highly cooperative learning environment with their parents. Parents who scored in the medium or high range on the pretest had significantly more interactions with their children concerning information about course tasks than those who scored low on the pretest.  相似文献   
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In a context of morphological expansion of the general population, how do athletes follow such a pattern of anthropometric growth? Is there any relation to performance? Biometric data including mass, height, body mass index (BMI) and age were collected for 50,376 American athletes representing 249,336 annual performers playing in professional baseball, football, ice hockey and basketball. Distributions by mass in National Football League (NFL) players are described by periods. Field goals have been studied in relation to players’ height in the National Basketball Association (NBA). Between 1871 and 2011, athletes from the four sports have increased significantly in mass, height and BMI, following a multi-exponential function series. Consequently, biometric differences between athletes and the general population are increasing gradually. Changes in the mass distribution within the NFL show the emergence of a biometrical specificity in relation to the field position. At the professional level, performance remains structured around precise biometric values. In the NBA, a height-attractor at 201.3 ± 6.3 cm for the best scorers is invariant, regardless of the level of play. These results suggest that laws of growth and biometrics drive high-level sport and organise performance around the specific constraint of each field position. Discrepancies between some mass and height developments question the (disproportionate) large mass increase (relative to the height increase) during the 1980s and 1990s.  相似文献   
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Since its introduction in the late 1990s, the unskilled and unaware effect motivated several further studies. As it stands, low-performing students are assumed to provide inaccurate and overconfident performance judgments. However, as research with second-order judgments (SOJs) indicates, they apparently have some metacognitive awareness of this. The current study with 266 undergraduate students aimed to provide in-depth insights into both the reasons for (in)accurate performance judgments and the appropriateness of SOJs. We implemented a general linear mixed model (GLMM) approach to study item-specific performance judgments in the domain of mathematics at the person and item level. The analyses replicated the well-known effects. However, the GLMM analyses revealed that low-performing students’ lower confidence apparently did not indicate subjective awareness, given that these students made inappropriate SOJs (lower confidence in accurate than in inaccurate judgments). In addition, students’ self-generated explanations for their judgements indicated that low-performing students have difficulties recognizing that they possess topic knowledge to solve an item, whereas high-performing students struggle with admitting that they do not know the answer to a question. In sum, our results indicate that students at all performance levels have some metacognitive weaknesses, which, however, occur subject to different judgment accuracy.  相似文献   
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School compacts between the business community and school officials have increased in recent years. This paper examines the development and implementation of a school compact program in the Detroit Public School system. The paper shows that the Detroit Compact was initiated by Detroit's corporate leaders. The article highlights some of the issues faced in forging compact agreements between the business community, Detroit Mayor Coleman Young, school officials, and school activists. The paper concludes with a discussion of some of the problems the Detroit Compact faces.  相似文献   
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