Synthetic biology in the view of European public funding organisations

We analysed the decisions of major European public funding organisations to fund or not to fund synthetic biology (SB) and related ethical, legal and social implication (ELSI) studies. We investigated the reaction of public organisations in six countries (Austria, France, Germany, the Netherlands, Switzerland and the U.K.) towards SB that may influence SB's further development in Europe. We examined R&D and ELSI communities and their particular funding situation. Our results show that the funding situation for SB varies considerably among the analysed countries, with the U.K. as the only country with an established funding scheme for R&D and ELSI that successfully integrates these research communities. Elsewhere, we determined a general lack of funding (France), difficulties in funding ELSI work (Switzerland), lack of an R&D community (Austria), too small ELSI communities (France, Switzerland, Netherlands), or difficulties in linking existing communities with available funding sources (Germany), partly due to an unclear SB definition.     

Characteristics of project management at institutions sponsoring National Library of Medicine MedlinePlus Go Local

Objectives:

Through interviews with the National Library of Medicine''s MedlinePlus Go Local collaborators, an evaluation team sought to identify process characteristics that are critical for long-term sustainability of Go Local projects and to describe the impact that Go Local projects have on sponsoring institutions.

Methods:

Go Local project coordinators (n = 44) at 31 sponsor institutions participated in semi-structured interviews about their experiences developing and maintaining Go Local sites. Interviews were summarized, checked for accuracy by the participating librarians, and analyzed using a general inductive methodology.

Results:

Institutional factors that support Go Local projects were identified through the interviews, as well as strategies for staffing and partnerships with external organizations. Positive outcomes for sponsoring institutions also were identified.

Conclusions:

The findings may influence the National Library of Medicine team''s decisions about improvements to its Go Local system and the support it provides to sponsoring institutions. The findings may benefit current sponsoring institutions as well as those considering or planning a Go Local project.

Highlights

• Many project coordinators said they underestimated the level of work their National Library of Medicine (NLM) MedlinePlus Go Local projects would require, but most expressed dedication to the project and optimism about project sustainability.
• An institutional record of community service or outreach and a director who was supportive of the project were important factors in the progress and sustainability of Go Local projects.
• Go Local projects brought recognition to some sponsoring institutions from their parent institutions or their communities and provided opportunities to establish better relations with other libraries and institutions.
• Go Local projects ran more smoothly when a person, even a temporary hire, with dedicated time for the project was in charge during the initial building phase. Volunteer assistance has been difficult to motivate and sustain.

Implications

• NLM''s Go Local proposal guidelines accurately identify the factors that institutions should pay close attention to when planning a Go Local project.
• NLM should emphasize continuity plans to address project coordinator turnover.
• NLM should develop a more formal orientation plan for new project coordinators to assist program continuity at the sponsoring institutions.

     

Individual and group performance of computerized educational tasks

This study examines the conditions under which task performance is accomplished more efficiently by a single individual or a group. 116 participants, ranging in age from high school level through holders of Master’s degrees, 58 women and the same number of men, were presented with a computer game based on educational software, arranged in five levels of difficulty. A comparison was made of the speed in which objectives were attained when performed individually and when divided among groups of two to four partners, controlling for the type of coordination required. Cases of expedient and inexpedient division of labor were identified, as were factors affecting feasibility, among them the number of simultaneous tasks to be performed, complexity level, number of participants and the intensity of coordination required among them. Basic principles, pertaining to the functional division of roles in learning activities and in educational administration, are discussed.     

WHEN IS A SCHOOL ENVIRONMENT PERCEIVED AS SUPPORTIVE BY BEGINNING MATHEMATICS TEACHERS? EFFECTS OF LEADERSHIP, TRUST, AUTONOMY AND APPRAISAL ON TEACHING QUALITY

This study examines the hypothesis that the more support beginning mathematics teachers perceive and the better they evaluate the management of their school, the higher their teaching quality is. Indicators of teaching quality were how the teachers, who were in their third year in the profession, regarded themselves able to cope with the challenges of mathematics instruction and generic tasks like classroom management and how satisfied they were with their job. Indicators of support were the level of appraisal and autonomy the teachers reported. School management indicators were the administrative leadership of the principal and the climate of trust as perceived by the teachers. Our results reveal that teacher support plays an important role in the quality of beginning mathematics teachers. All quality indicators improved significantly if beginning teachers reported more appraisal and autonomy. A climate of trust plays an important role for the extent of autonomy perceived. Administrative leadership was significantly related to the amount of appraisal the teachers reported. Our results provide important information on how to steer a school so that the quality of beginning mathematics teachers is maximized.     

Structural Equations and Causal Explanations: Some Challenges for Causal SEM

One common application of structural equation modeling (SEM) involves expressing and empirically investigating causal explanations. Nonetheless, several aspects of causal explanation that have an impact on behavioral science methodology remain poorly understood. It remains unclear whether applications of SEM should attempt to provide complete explanations or partial explanations. Moreover, it remains unclear what sorts of things researchers can best take as causes and effects. Finally, the meaning of causal assertions itself remains poorly understood. Attempting to clarify the use of structural equations as causal explanations by addressing these issues has implications for behavioral science methodology because applications of SEM typically remain vague about causation and thus about their substantive conclusions. Research aimed at clarifying these issues can lead to a sharper and more refined use of SEM for causal explanation, and by extension, clarify behavioral science methodology more generally.     

Governance for system optimization and system change: The case of urban waste

This paper analyses urban waste systems to explore how local authorities can resolve challenges related to climate change, urbanization and resource depletion. The paper investigates how different public governance regimes affect local authorities’ ability to move upwards in the waste hierarchy. It identifies three different governance regimes – traditional bureaucracy, new public management and networked governance – and uses the insights from innovation in urban waste in three Norwegian city regions – Oslo, Drammen and Bergen – to illuminate how these regimes possess both strengths and weaknesses in how they affect system optimization and system change. The observed working practices signal that the issue of urban waste systems is perceived as a challenge of system optimization rather than system change. Viewing this as a challenge requiring system change would probably have ensured a stronger directionality and a broader anchoring of actors. Such an approach is likely to have arrived at a waste prevention mode earlier than the step-by-step-solutions implemented so far. The paper concludes that there is not one best governance regime, but a need to acknowledge their co-existence and carefully consider the characteristics of the respective regimes in order to arrange urban waste systems for long-term dynamic and sustainable city regions.