Nuclear magnetic resonance spectroscopy as a new approach for improvement of early diagnosis and risk stratification of prostate cancer

Prostate cancer (PCa) is the second most common male cancer worldwide and the fifth leading cause of death from cancer in men. Early detection and risk stratification is the most effective way to improve the survival of PCa patients. Current PCa biomarkers lack sufficient sensitivity and specificity to cancer. Metabolite biomarkers are evolving as a new diagnostic tool. This review is aimed to evaluate the potential of metabolite biomarkers for early detection, risk assessment, and monitoring of PCa. Of the 154 identified publications, 27 and 38 were original papers on urine and serum metabolomics, respectively. Nuclear magnetic resonance (NMR) is a promising method for measuring concentrations of metabolites in complex samples with good reproducibility, high sensitivity, and simple sample processing. Especially urine-based NMR metabolomics has the potential to be a cost-efficient method for the early detection of PCa, risk stratification, and monitoring treatment efficacy.     

Providing vertical coherence in explanations and promoting reasoning across levels of biological organization when teaching evolution

Students' explanations of biological phenomena are frequently characterized by disconnects between levels and confusion of levels. The purpose of this research is to investigate the effects of a hands-on lab activity that aims at fostering the ability to reason across levels. A total of 197 students (18 years of age) participated in a randomized, pre–post-test design study. Students in the experimental group engaged in a lab activity focused on artificial selection and designed to demonstrate how selection affects both phenotypes and genotypes. In contrast, the lab activity in the comparison group focused on phenotype alone. Data sources for the study included pre-tests of basic concepts in genetics and evolution and two post-test items requiring the students to reproduce and apply their knowledge about artificial selection. The findings indicated that the lab activity which allowed students to explore the interplay between different levels, provided vertical coherence and enhanced students’ ability to explain evolutionary change in both reproduction and transfer items. In contrast, the lab activity in the comparison group failed to do so, and most students did not improve their ability to explain evolutionary change. Implications for instruction and recommendations for further research are discussed in light of these findings.     

Impact Factor: Early Career Research & Digital Scholarship

It is becoming increasingly vital to publish and share research as well as get citations for the purpose of researcher visibility. The publishing options available for research distribution seem endless. It really is an academic jungle out there! This article reviews why early career researchers and graduate scholars should consider their research impact in the digital age.     

Education and the Contested Meanings of ‘Global Citizenship’

This article examines the oftentaken-for-granted educational policy and curricular discourses of globalization and global citizenship within their larger cultural, political, and economically uneven histories and unequal consequences. Drawing upon evidence from recent scholarship on the implications for classroom pedagogy embodied inefforts to internationalize curricula in the North American university contexts, as well as specific related efforts in one Canadian context, the University of British Columbia,this article unpacks the contested meanings of global citizenship from above and below.The author analyzes three dominant curricular discourses of global citizenship. Far from weakening the Canadian state and building instances of transnational democratic educational communities, these dominant discourses may actually reinforce notions of Canadian gendered and racialized nation-building and nationalism. The article raises questions about what an alternative curricular and educational policy discourse from below premised upon efforts to decolonize curricula might look like. By way of provisional conclusion, the author discusses some promising examples of such an alternative,showing how they depend on seeing the relations between the local and global neither as fixed abstractions nor as a slogan system to be applied in absolutist racial, geographical,national, or culturally essentialist terms.     

Blocking landing techniques in volleyball and the possible association with anterior cruciate ligament injury

The number and type of landings performed after blocking during volleyball matches has been related to the potential risk of ACL injury. The aim of the present study was to determine whether gender affects the frequency of specific blocking landing techniques with potential risk of ACL injury from the perspective of foot contact and subsequent movement after the block used by volleyball players during competitive matches. Three matches involving four female volleyball teams (fourteen sets) and three matches involving four male volleyball teams (thirteen sets) in the Czech Republic were analyzed for this study. A Pearson chi-square test of independence was used to detect the relationship between gender and different blocking techniques. The results of the present study showed that gender affected single-leg landings with subsequent movement in lateral direction and double-leg landings. Although the total number of landings was lower for male athletes than for female athletes, a larger portion of male athletes demonstrated single leg landings with a subsequent movement than female athletes. Single leg landings with a subsequent movement have a higher potential risk of ACL injury.     

Assessing the impact of the funding environment on researchers’ risk aversion: the use of citation statistics

The funding environment has a profound impact on researchers’ behavior. In particular, it influences their freedom and readiness to conduct research ventures with highly uncertain outcomes. In this conceptual paper, we propose a concise new methodology to evaluate researchers’ risk aversion based on citation statistics. The derived single-number criterion P_R is sensitive to the ratio of high impact versus average impact work, based on citation counts. We demonstrate the usefulness of P_R on a micro and meso level in the field of chemistry. P_R is a potentially valuable tool for managers in higher education, to control for the impact of their funding instruments. The conducted testing may, in addition, contribute to the literature stream dealing with the effects of peer review in the allocation of research funding. Our results support the view that peer review fosters mainstream research. However, faculties with the highest percentages of third-party funding may find ways to avoid the restrictive effects. We also find evidence that permanent positions back risky research endeavors.     

ILLITERACY AND OLDER ADULTS: INDIVIDUAL AND SOCIETAL IMPLICATIONS

Literacy has become an important predictor of well being in old age. Being literate in today's society demands a myriad of functional abilities, which, when absent, can have dramatic health, economic, and social consequences. The purpose of this study was to develop a framework for defining literacy within an increasingly technological society, and to explore the experience of illiteracy among older adults. To examine these issues, qualitative data were gathered from an adult literacy program in Hamilton, Ohio. Data collected through these interactions suggest that the devastating effects of illiteracy are exacerbated throughout the lifecourse, resulting in significant disadvantage for older adults.     

Mechanism of craquelure pattern formation on panel paintings

The drying shrinkage accumulation from exposure of freshly prepared gesso layers to relative humidity (RH) cycles was determined to elucidate the mechanism of craquelure pattern formation on panel paintings. The progresive drying shrinkage of the gesso is observed only under the cycles going to high RH levels which bring about transitions from brittle to ductile state of the material. The first incidence of fracture on the gesso layers occurred after a limited number of cycles ranging between a few and 100 for a range of layer thickness between 0.5 and 1?mm. The craquelure patterns stabilised also after a limited number of cycles (30 for the 1-mm thick layer). Upon increase in the gesso layer thickness, the strength of the layer is reduced and the spacing of shrinkage fractures increases. The study demonstrated that craquelure patterns, mimicking historical ones, can be realistically produced in laboratory conditions. Such studies would provide useful information for preparing specimens simulating historic panel paintings and would inform the current efforts on automatic, computer-aided classifications of crack formations on paintings.