Co-inheritance of HbD Iran/Beta Thalassemia IVS1–5 (G?>?C) Trait in a Punjabi Lady with Diabetes

The present report describes the molecular study of HbD ^Iran (beta) 22 Glu → Gln associated with β-Thalassemia IVS1–5 (G > C) found in India, and the first case in which mutation has been identified using mass spectrometry. Given the apparent ethnic origin and the mobility of the variant hemoglobin at alkaline pH, hemoglobin D-Punjab would be suspected, but HPLC excluded this possibility. Further characterization of hemoglobinopathy was made by using nondenaturing gel electrophoresis and matrix assisted laser desorption ionization mass spectrometry and IVS1–5 being validated by reverse dot blot hybridization followed by sequencing of the β-globin gene.     

Classroom Assessment and Large‐Scale Psychometrics: Shall the Twain Meet? (A Conversation With Margaret Heritage and Neal Kingston)

Classroom assessment and large‐scale assessment have, for the most part, existed in mutual isolation. Some experts have felt this is for the best and others have been concerned that the schism limits the potential contribution of both forms of assessment. Margaret Heritage has long been a champion of best practices in classroom assessment. Neal Kingston has been involved with the application of psychometrics to large‐scale assessments for four decades. Together they discuss what commonalities and differences exist between these two assessment contexts, whether the twain should meet, what impediments or concerns exist, and whether they expect the status quo will change at all in the near future. Based on their joint keynote address at the NCME Special Conference on Classroom Assessment and Large‐Scale Psychometrics, they have expanded and constructed this discussion piece.     

The effect of nonnutritive satiation on the learning of a flavor preference by rats

On each day of training in Experiment 1, hungry rats were given one flavored saccharin solution followed by a differently flavored saccharin solution. The rats drank more of the first flavor during training, but preferred the second flavor in a subsequent choice test. In Experiment 2, the two flavored saccharin solutions were provided on alternate days, with one flavor being preceded by nothing and the other flavor by plain saccharin. The rats drank more of the flavor preceded by nothing during training, but preferred the other flavor in a subsequent choice test. These results suggest that a state of nonnutritive satiation can reinforce a flavor preference.     

Lab-on-a-chip workshop activities for secondary school students

The ability to engage and inspire younger generations in novel areas of science is important for bringing new researchers into a burgeoning field, such as lab-on-a-chip. We recently held a lab-on-a-chip workshop for secondary school students, for which we developed a number of hands-on activities that explained various aspects of microfluidic technology, including fabrication (milling and moulding of microfluidic devices, and wax printing of microfluidic paper-based analytical devices, so-called μPADs), flow regimes (gradient formation via diffusive mixing), and applications (tissue analysis and μPADs). Questionnaires completed by the students indicated that they found the workshop both interesting and informative, with all activities proving successful, while providing feedback that could be incorporated into later iterations of the event.     

Mapping the landscapes of bullying

Past bullying research has consistently identified common locations (e.g. bathrooms, hallways, playgrounds) on school campuses where bullying occurs, but not specific locations. This limitation does not allow researchers to take into account the unique geography of individual schools and how it contributes to bullying. A random sample of 741 grade 4–6 students from nine different elementary schools identified where bullying occurs on a campus map and this information was analysed in Geographic Information Systems (GIS). While this study offers preliminary findings (e.g. diffusion of bullying, specific locations for bullying) that increase awareness about bullying, the emphasis in this paper is to present a new methodological tool in the analysis of bullying. The use of GIS mapping to analyse bullying offer researchers an advanced instrument to understand the experience of bullying within the physical context of a school. These preliminary findings focus future research.     

Innovation after Brexit

Brexit is intended to return autonomy for law-making to the UK Parliament, and this opportunity could be used to improve intellectual property laws. These were originally drafted to support innovation, but like other laws of property they were captured by interests. The result is that their original function has been far surpassed in economic importance by their use for moving corporate profits to and through tax havens for tax evasion and avoidance. Although an opportunity to improve information protection laws may indeed result, Britain has never been a leader in drafting these, compared with Germany and the United States. Also, to the extent that better laws could refocus investment on technological innovation, and away from financial innovation, it could be expected that they would be opposed by interests with a major stronghold in the City of London. Reference is made to specific proposals for change already advanced in Prometheus, to which is added a new suggestion about how more generous overhead payments from public funding of innovation could help to stimulate more firms to bid for this. Also, a proposal is made for a means of rectifying a series of legal decisions which have had the effect of denying firms the ability to benefit from new ideas offered by outsiders.     

Effects of aerobic exercise on overweight children's cognitive functioning: a randomized controlled trial

The study tested the effect of aerobic exercise training on executive function in overweight children. Ninety-four sedentary, overweight but otherwise healthy children (mean age = 9.2 years, body mass index 85th percentile) were randomized to a low-dose (20 min/day exercise), high-dose (40 min/day exercise), or control condition. Exercise sessions met 5 days/week for 15 weeks. The Cognitive Assessment System (CAS), a standardized test of cognitive processes, was administered individually before and following intervention. Analysis of covariance on posttest scores revealed effects on executive function. Group differences emerged for the CAS Planning scale (p = .03). Planning scores for the high-dose group were significantly greater than those of the control group. Exercise may prove to be a simple, yet important, method of enhancing aspects of children's mental functioning that are central to cognitive and social development.