Lipid Parameters, Doses and Blood Levels of Calcineurin Inhibitors in Renal Transplant Patients

The calcineurin inhibitors (CNIs) [cyclosporin A (CsA) and tacrolimus (Tac)] are currently the most widely prescribed drugs for maintenance of immunosuppression after renal transplantation. These immunosuppressants are associated with side effects such as hyperlipidemia. We evaluated the differential effects of different CNIs on serum lipid parameters in renal transplant patients. Moreover, the aim of this study is to investigate the relationships between doses and blood levels of CNIs, and blood levels of CNIs and lipid parameters retrospectively. Two groups of 98 non-diabetic renal transplant patients, each treated with different CNIs, were studied: group A (n = 50, mean age: 31 ± 10 years), CsA, mycophenolate mofetil/azathioprin, steroid; group B (I = 48, mean age: 34 ± 12 years), Tac, mycophenolate mofetil/azathioprin, steroid. In renal transplant patients, CNIs blood levels and doses were examined at 1, 3, 6, 9, and 12 months after transplantation. Biochemical laboratory parameters including plasma lipids [total-cholesterol (CHOL), low-density lipoprotein (LDL)–CHOL, high-density lipoprotein (HDL)–CHOL, and triglycerides (TG)], CNI levels and doses were examined at 1, 3, 6, 9, and 12 months after transplantation. None of the patients received anti-lipidemic drugs during the study period. Blood levels of CNIs were detectable in all whole-blood samples by Cloned- Enzyme-Donor Immunoassay (CEDIA). The relationship between CNIs blood levels and CHOL, (LDL)–CHOL, HDL–CHOL, TG were evaluated. The mean serum CHOL levels and LDL–CHOL levels of patients in group A were found significantly higher than the patients in group B during the 12 month of follow up (p < 0.05). There was no significant difference in TG and HDL–CHOL plasma levels between group A and group B (p > 0.005). In group A the daily dose of CsA was significantly correlated with the mean blood levels of CsA at the 1st and 3rd months (r = 0.387, p = 0.005; r = 0.386, p = 0.006), respectively. In group A, the daily dose of CsA was significantly correlated with the mean serum TG levels during the 12 month of follow up (r = 0.420, p = 0.003). In group B, the daily dose of Tac was significantly correlated with the mean blood level of Tac (r = 0.335, p = 0.020) at the 1st month. No correlation was found between mean Tac blood levels and lipid parameters during the 12-month of follow up (p > 0.05). Significant positive correlation was observed between the CsA blood levels and LDL–CHOL levels (r = 0.338, p = 0.027) at the 3rd month. In the renal transplant patients with well functioning grafts, CsA therapy is associated with increased CHOL and LDL–CHOL ratio which represents an increased atherogenic risk tended to be associated with CsA. Serum LDL–CHOL levels may be effected by blood CsA levels.     

Main trends in graduate study in basic sciences in Turkish universities: a quantitative overview

This paper seeks to trace the development of graduate studies in basic sciences in Turkish universities from origins to the present day. The study includes a sketch of the historical background of higher education from its start in medieval madrasahs and Istanbul Darulfunun (The House of Sciences), to the transition into present-day university education, i.e., to the beginnings of modern graduate study and the emergence of new universities. Empirical statistics are given to substantiate the rapid growth of graduate study and of the number of degrees produced since the 1980s. The mean number of Ph.D. Degrees per year has increased from a few in a single university in the 1930s to nearly a hundred in today's twenty seven universities in Turkey in the 1980s. Finally, a quantitative overview of the growth trends in graduate study in basic sciences as well as an assessment of the present degree productivity of Turkish universities are presented.     

The Evolution of Leadership Research in Higher Education for Two Decades (1995-2014): A Bibliometric and Content Analysis

ABSTRACT

The present study aims to examine the leadership research in higher education in order to shed light on its development during the last two decades by revealing the evolving trends in research on leadership in higher education, the most prominent scholars working on related research, the most popular topics in related research, and the countries in which the related studies are based. Bibliometric method was employed in the analysis of the original research and review papers published in five prominent higher education journals between 1995 and 2014: Higher Education, Research in Higher Education, Studies in Higher Education, The Journal of Higher Education and The Review of Higher Education. The results of this bibliometric analysis show that the majority of the related articles come from three countries: the U.S.A., the UK and Australia. It is also found that the leadership research in higher education is still very scarce and has not shown any meaningful increase during the last two decades. In addition, content analysis is used to provide more in-depth information about the topical focus, purpose and methodology of the selected articles. The results of content analyses are discussed in detail, and suggestions for the future research are provided.     

Game addiction and academic achievement

The primary aim of this study was to investigate the correlation between game addiction and academic achievement. The secondary aim was to adapt a self-report instrument to measure game addiction. Three hundred and seventy high school students participated in this study. Data were collected via an online questionnaire that included a brief explanation of the aim of the study, demographical questions, game addiction scale (GAS) and the grade point average of the current year. The GAS had two forms: (i) 21-item and (ii) 7-item. Game addiction and academic achievement were negatively correlated but this correlation was not supported by regression and structural equation modelling analyses. The present study primarily suggests that there may be a negative correlation between game addiction and academic achievement; however, this correlation may be qualified as negligible. In addition, the two forms of the GAS were adapted for Turkish language with reliability and validity to measure computer and video game addiction in adolescents as promising instruments.     

Cognitions of Expert Supervisors in Academe: A Concept Mapping Approach

Eighteen expert supervisors reported their thoughts while preparing for, conducting, and evaluating their supervision sessions. Concept mapping (Kane & Trochim, 2007 ) yielded 195 cognitions classified into 25 cognitive categories organized into 5 supervision areas: conceptualization of supervision, supervisee assessment, supervisory relationship, supervisor self‐assessment, and administration of supervision. Implications for future research and supervisor training programs are discussed.     

Factors Influencing Schoolchildren's Responses to a Questionnaire in Wildlife Conservation Education

Questionnaires are important tools for assessing attitudes regarding conservation issues. However, they are not easily comparable and their reliability has been insufficiently assessed. We examined factors influencing responses to open- and closed-ended questions about animal conservation to more than 600 schoolchildren (9 years old on average). We analysed the level of understanding, controllable (e.g. sample size) and less controllable factors (e.g. affectivity). Most children responded appropriately to the questions, but subtle changes in the phrasing influenced the answers. Affectivity towards endearing species and spontaneity also influenced the responses whereas small sample sizes (～50 children) provided relatively stable patterns. Overall, we suggest that standardization of questionnaires administered over large spatial and time scales is needed to accurately assess children's attitudes towards conservation issues.     

Teachers’ beliefs about improving transfer of algebraic skills from mathematics into physics in senior pre-university education

ABSTRACT

Students in senior pre-university education encounter difficulties in the application of mathematics into physics. This paper presents the outcome of an explorative qualitative study of teachers’ beliefs about improving the transfer of algebraic skills from mathematics into physics. We interviewed 10 mathematics and 10 physics teachers using a semi-structured questionnaire that was based on an algebraic transfer problem. Almost all teachers acknowledged this transfer problem and considered it to be important. We found a continuum of teachers’ beliefs about aspects influencing transfer, including beliefs on improving this transfer. Together with identified improvement aspects about coherent mathematics education, these may help reduce physics teachers’ frustrations who spend extra time on re-teaching mathematics. Teachers think that transfer does not happen, because students see both subjects as separate disciplines. Contrary to most physics teachers, most mathematics teachers do not feel the need to collaborate with physics teachers. We found two extreme, opposite beliefs about the transfer of algebraic skills into physics. An intermediate group believes that only an integrated approach can solve the transfer problem. Some of the teachers’ beliefs could be organised into a beliefs system. Further research could investigate to which extent such beliefs systems exist and which beliefs these contain.     

The Effects of Motivational Styles on Group Work and Discussion-based Seminars

The paper reports the effect of motivational styles on group work and discussion-based teaching in an environmental science course. The students' motivational styles were explored by a questionnaire whose items were written to correspond to four motivational patterns: achiever, curious, conscientious and sociable. A total of 180 university students from an Elementary Teaching Department participated in this study. The results showed that achiever students tended to dislike being involved in group work. On the other hand, curious, social and conscientious students tended to prefer working in groups. Discussion-based teaching appeared to be attractive for almost all students, although they have different motivational styles. The implications of the results for teaching and learning are discussed.