The first 'molecular disease': a story of Linus Pauling, the intellectual patron

In November 1949, chemist Linus Pauling and three colleagues published an article on sickle-cell anemia, a study that opened up new and exciting possibilities for research into such 'molecular diseases'. Even before this celebrated publication appeared in Science, Pauling foresaw its potential benefits and announced it as a medical breakthrough: '... our structural chemistry and understanding of molecules is getting to the point where it should be of assistance in converting medicine into a real science' [Guiles, R. (1949) Discovery of blood disease called key to cancer research. The Detroit Times 13 Sep 1949, Newspaper Clippings 1949n.18, Pauling Papers.]. Their discovery--that this debilitating disorder was caused by an abnormal form of hemoglobin--was borne out of a rich mix of expertise, from Pauling's remarkable intuition to the careful experimental chemistry of his student Harvey A. Itano. It also relied upon technological innovation: a custom-made electrophoresis machine housed at the California Institute of Technology was the perfect tool to reveal fundamental chemical differences between normal and abnormal forms of hemoglobin. Not only did this work establish a new way of looking at inherited diseases, it also stimulated the mass production of the electrophoresis machine as an essential investigative and diagnostic tool. A close inspection of this case study illustrates just how Pauling ran his laboratory and helps to explain how one man could achieve so much over his lifetime.     

Functional impact of emotions on athletic performance: comparing the IZOF model and the directional perception approach

The aim of this study was to examine the impact of emotions on athletic performance within the frameworks of the Individual Zones of Optimal Functioning (IZOF) model and the directional perception approach. Intensity, functional impact, and hedonic tone of trait and state anxiety, self-confidence, idiosyncratic emotions, and bodily symptoms were assessed in high-level Italian swimmers and track and field athletes (N = 56). Three standards of performance (poor, average, and good), derived from retrospective self-ratings across one to three competitions (a total of 90 observations), were used as independent variables in the analysis of variance of intensity, intra-individual, and direction scores of anxiety, self-confidence, idiosyncratic emotions, and bodily symptoms. Subsequently, intra-individual scores were categorized as near to or distant from optimal/dysfunctional zones and entered as the independent variable in the analysis of direction scores. The results provided support for the predictions stemming from both the IZOF model and the directional approach, as well as help in interpreting direction of anxiety and other idiosyncratic emotions within the IZOF framework. Athletes tended to perceive emotional levels approximating an individual's optimal zone as facilitative-pleasant, and emotional levels approximating an individual's dysfunctional zone as debilitative-unpleasant.     

Benefits of an external focus of attention: common coding or conscious processing?

We conducted two experiments to assess the effect attentional focus has on learning a complex motor skill and subsequent performance under secondary task loading. Participants in Experiment 1 learnt a golf putting task (300 practice trials) with a single instruction to either focus on their hands (internal focus) or the movement of the putter (external focus). No group differences were evident during learning or retention. Differences between the groups were only apparent under secondary task load; the external group's performance remained robust, while the internal group suffered a drop in performance. Verbal protocols demonstrated that the internal group accumulated significantly more internal knowledge and more task-relevant knowledge in general than the external group. Experiment 2 was designed to establish whether greater internal focus knowledge or greater explicit rule build up in general was responsible for performance breakdown. Two groups were presented with a set of six internal or external rules. Again, no performance differences were found during learning or retention. During the secondary task, both groups experienced performance deterioration. It was concluded that accumulation of explicit rules to guide performance was responsible for the internal group's breakdown in performance under secondary task loading and may be responsible for some of the performance differences reported previously.     

Combining Career and Couples Counseling for College Students: A Narrative Approach

Career and personal counseling have been dichotomized as distinct practices in much of the counseling literature. However, many college students seek counseling for career development and romantic relationship issues occurring concomitantly. A model for addressing career and relationship issues with heterosexual college couples in a group format is presented. An approach grounded in narrative theory is described, and case examples are provided to illustrate the model.     

Latino Adolescents’ Ethnic Identity: Is There a Developmental Progression and Does Growth in Ethnic Identity Predict Growth in Self‐Esteem?

The current longitudinal study of 323 Latino adolescents (50.5% male; M age = 15.31 years) examined whether ethnic identity exploration, resolution, and affirmation demonstrated significant growth over a 4-year period and whether growth in ethnic identity predicted growth in self-esteem. Findings from multiple-group latent growth curve models revealed that exploration, resolution, and affirmation all increased significantly from middle to late adolescence for Latina girls. For Latino boys, only affirmation increased significantly. Furthermore, only growth in exploration predicted growth in boys' and girls' self-esteem. This research indicates that patterns of growth in ethnic identity vary by adolescent sex. Furthermore, findings underscore the need to examine the unique contributions of each ethnic identity component, rather than using a composite ethnic identity score.     

Classroom-based science research at the introductory level: changes in career choices and attitude

Our study, focused on classroom-based research at the introductory level and using the Phage Genomics course as the model, shows evidence that first-year students doing research learn the process of science as well as how scientists practice science. A preliminary but notable outcome of our work, which is based on a small sample, is the change in student interest in considering different career choices such as graduate education and science in general. This is particularly notable, as previous research has described research internships as clarifying or confirming rather than changing undergraduates' decisions to pursue graduate education. We hypothesize that our results differ from previous studies of the impact of engaging in research because the students in our study are still in the early stages of their undergraduate careers. Our work builds upon the classroom-based research movement and should be viewed as encouraging to the Vision and Change in Undergraduate Biology Education movement advocated by the American Association for the Advancement of Science, the National Science Foundation, and other undergraduate education stakeholders.