An audit of total and free thyroxine measurements in screening for hypo and hyperthyroidism in patients using chemiluminescence immunoassay

An audit of 2509 patient specimens analyzed for both total thyroxine (TT4) and free thyroxine (FT4) by the ACS-180 automated chemiluminescence immunoassay analyzer revealed that there were 219 discrepancies (8.7% of the total). A discrepancy was defined as one analyte within its reference range and the other outside. The discrepant results were divided into 4 groups: group A: normal TT4, but decreased FT4, 101 patients (4.0%); group B: increased TT4, normal FT4, 78 patients (3.1%); group C: decreased TT4, normal FT4, 34 patients (1.4%); and group D: normal TT4, increased FT4, 6 patients (0.2%). TSH measurements were available, by a 3^rd generation chemiluminescent assay, in 142 of these patients, and were consistent with the FT4 result in 72 patients, with TT4 in 61 cases and with neither in 9 patients. The clinical diagnosis was investigated in a subgroup of 43 endocrine patients. Thirteen of the 20 endocrine patients in group A were diagnosed as hypothyroid, with a measured serum TSH, in 11 of them, of median 14.6, range 1.2 to 46.2 μlU/ml. Eleven of the 19 endocrine patients in group B were on thyroid replacement, with a measured serum TSH, in 7 of them of <0.01 μlU/ml. The audit of current laboratory practice led to a suggestion to replace the current thyroid function screening strategy of measuring both TT4 and FT4 by the combination of FT4 and TSH. The reasons for the discrepancies and the alternative strategies for screening of thyroid function are discussed.     

National institutions, public-private knowledge flows, and innovation performance: A comparative study of the biotechnology industry in the US and France

The biotechnology industry is a striking example of the disconnect between the location of knowledge creation and its commercial development. I argue that national technological performance in biotechnology is critically affected by institutions governing scientific careers, which shape the professional identities and boundary-spanning activities of research scientists. I test this in a comparison of the United States and France. Drawing on fieldwork and analysis of patent data, I compare institutional frameworks and estimate models of forward patent citations. The models show that entrepreneurial firms are associated with high-performing innovations in this sector whereas large established firms perform poorly in both countries, and highlight the importance of institutions in creating country-specific combinations of human capital with organizational capabilities.     

Many Voices: Building a Biblioblogosphere in Ireland

ABSTRACT

Blogging has been associated with the Library and Information Science (LIS) community for some time now. Libfocus.com is an online blog that was founded in 2011. Its goal was to create a communal communication space for LIS professionals in Ireland and beyond, to share and discuss issues and ideas. The content of the blog is curated by an editorial team and features guest bloggers from across all sectors and experience levels. Using a qualitative methodological approach, open-ended surveys were conducted with twelve previous guest bloggers, in order to explore how and why Irish-based LIS professionals choose to communicate through blogging. It is hoped that this evidence will provide a greater understanding of both the value and effectiveness of blogging as an outreach and communication tool within the profession, helping both libraries and librarians to be more strategic in their use of it as a medium.     

Sophomores speaking: An exploratory study of student research practices

This article describes an exploratory study of the research behaviors of sophomore students at a small liberal arts college. In light of the transitional nature of the sophomore year and the limited data available on the research practices of sophomores, the authors sought to better understand the following: Students’ topic selection, help-seeking behavior, types of sources consulted, source selection criteria, research challenges, and changes in information-seeking behavior from the first year to the sophomore year. This article describes findings from a survey and in-depth interviews, and it offers recommendations for further research.     

Storying Joanne, 1 an undergraduate mathematician

In this article two different accounts are juxtaposed. In one, we use a variety of texts to narrate the story of Joanne, a woman undergraduate student of mathematics. Like many of our mature students Joanne came to the university with a ‘non‐traditional’ academic background. We describe how Joanne developed as a learner of mathematics and connect this to our ways of working in the undergraduate mathematics classroom. We believe that our pedagogy is unusual outside (some) school classrooms and suggest it allows our students to develop positive ‘disciplinary relationships’. In the other, we grapple with the issues raised by telling other people’s stories especially when we are also characters within it. Our intention has been that, in interweaving these two threads, each helps us understand more about the other.     

What are Middle School Students Talking About During Clicker Questions? Characterizing Small-Group Conversations Mediated by Classroom Response Systems

There is a growing interest in using classroom response systems or clickers in science classrooms at both the university and K-12 levels. Typically, when instructors use this technology, students are asked to answer and discuss clicker questions with their peers. The existing literature on using clickers at the K-12 level has largely focused on the efficacy of clicker implementation, with few studies investigating collaboration and discourse among students. To expand on this work, we investigated the question: Does clicker use promote productive peer discussion among middle school science students? Specifically, we collected data from middle school students in a physical science course. Students were asked to answer a clicker question individually, discuss the question with their peers, answer the same question again, and then subsequently answer a new matched-pair question individually. We audio recorded the peer conversations to characterize the nature of the student discourse. To analyze these conversations, we used a grounded analysis approach and drew on literature about collaborative knowledge co-construction. The analysis of the conversations revealed that middle school students talked about science content and collaboratively discussed ideas. Furthermore, the majority of conversations, both ones that positively and negatively impacted student performance, contained evidence of collaborative knowledge co-construction.     

Negotiating status hierarchies in middle school inquiry science: implications for marginal non-participation

Instructional Science - While previous classroom studies of status hierarchies tell us who has low status and how to increase those learners’ participation in small group contexts via...     

Measuring perceived social support: Development of the child and adolescent social support scale (CASSS)

The measurement of students' social support has become a popular topic in education and psychology, yet measurement tools in this area are limited. In this study, we use a large, representative sample to conduct confirmatory factor, reliability, and correlational analyses of scores on the Child and Adolescent Social Support Scale (CASSS; Malecki, Demaray, Elliott, & Nolten, 1999). These analyses revealed evidence of reliability, a four‐factor structure (Parent, Teacher, Classmate, and Close Friend subscales), and construct validity. The results of this study indicate that the CASSS covaries as predicted with the clinically important constructs of self‐concept, social skills, and behavioral indicators. There is evidence that the CASSS can be used to understand children and adolescents' perceived social support. © 2002 John Wiley & Sons, Inc.     

A Decline in Drawing Ability?

This research surveys changing attitudes to drawing pedagogy, in the context of digitisation, moves toward student‐centred learning in art & design higher education, and anecdotal reports of declining competence. Based on student, teacher and examiner’s experiences, it has been possible to gain insights into how drawing instruction has changed over the past generation. This article examines the attitudes, values and concerns of students and educators regarding drawing instruction. The study reveals that, in the UK, drawing skills are considered to be gradually declining, while traditional notions of skill are called into question. Drawing as a means of visual recording, representation and communication remains valued, although no longer essential as it once was; drawing to augment thought process is increasingly recognised as an integral skill which enables innovation. The latter is rarely ‘taught’ but relies on core competencies that many lecturers fear are being eroded. Increasing value is placed on drawing ‘as process’, as provision is moving towards individualised instruction requiring students to work independently. While new technologies are a factor, this article re‐frames the issue as an imbalance between creative outcomes and creative process, with a disparity between school and university levels. This article calls for a renewed emphasis on ‘drawing as process’ as preparation for university, and for further consideration of the core competencies underpinning the use of drawing as a tool of thought, and how these might be standardised.