Monitoring Coagulation Proteins During Progression of Liver Disease

This work was designated to monitor the coagulation abnormalities associated with the gradual progression of liver diseases. The study included fifty patients; forty were diagnosed with liver cirrhosis with different stages categorized according to the Childs-Pugh classification and another ten patients were diagnosed with hepatocellular carcinoma (HCC). Haemostatic variables including fibrinogen (FI), calcium (FIV), transglutaminase (FXIII), prothrombin time (PT) and platelet count were estimated in patients and compared with the baseline levels of healthy subjects (n = 10). The results demonstrated that the fibrinogen level was progressively decreased, whereas PT was progressively prolonged in Child A, Child B and Child C groups. The maximum deterioration was observed in HCC patients. Calcium significantly increased in mild (Child A) and moderate (Child B) but not in Child C cirrhosis and HCC patients. FXIII level did not show any significant changes in cirrhotic patients compared to healthy group. Some of the haemostatic variables we investigated were correlated with serum albumin and bilirubin but not with aminotransferases (ALT and AST). The results indicated that the haemostatic abnormalities in fibrinogen, calcium and PT (but not FXIII) were deteriorated in parallel with the gradual regression of the constitutional function of liver.     

Fractional-order global sliding mode controller for an uncertain quadrotor UAVs subjected to external disturbances

In the present paper, the problem of designing a global sliding mode control scheme based on fractional operators for tracking a quadrotor trajectory is investigated. The model of the quadrotor system is given with disturbances and uncertainties. To converge in short finite time of the sliding manifold, a classical quadratic Lyapunov function was used and also a global stabilization of the quadrotor system is ensured. The proposed controller can be ensured the robustness against external disturbances and model uncertainties. Some scenarios are illustrated in this paper. Finally, a comparative study to three other controllers is provided to show the validity and feasibility of the proposed method.     

Nephroprotective effects of Zingiber zerumbet Smith ethyl acetate extract against paracetamol-induced nephrotoxicity and oxidative stress in rats

Paracetamol (PCM) overdose can cause nephrotoxicity with oxidative stress as one of the possible mechanisms mediating the event. In this study, the effects of ethyl acetate extract of Zingiber zerumbet rhizome [200 mg per kg of body weight (mg/kg) and 400 mg/kg] on PCM-induced nephrotoxicity were examined. Rats were divided into five groups containing 10 rats each. The control group received distilled water while other groups were treated with extract alone (400 mg/kg), PCM alone (750 mg/kg), 750 mg/kg PCM+200 mg/kg extract (PCM+ 200-extract), and 750 mg/kg PCM+400 mg/kg extract (PCM+400-extract), respectively, for seven consecutive days. The Z. zerumbet extract was given intraperitoneally concurrent with oral administration of PCM. Treatment with Z. zerumbet extract at doses of 200 and 400 mg/kg prevented the PCM-induced nephrotoxicity and oxidative impairments of the kidney, as evidenced by a significantly reduced (P<0.05) level of plasma creatinine, plasma and renal malondialdehyde (MDA), plasma protein carbonyl, and renal advanced oxidation protein product (AOPP). Furthermore, both doses were also able to induce a significant increment (P<0.05) of plasma and renal levels of glutathione (GSH) and plasma superoxide dismutase (SOD) activity. The nephroprotective effects of Z. zerumbet extract were confirmed by a reduced intensity of renal cellular damage, as evidenced by histological findings. Moreover, Z. zerumbet extract administered at 400 mg/kg was found to show greater protective effects than that at 200 mg/kg. In conclusion, ethyl acetate extract of Z. zerumbet rhizome has a protective role against PCM-induced nephrotoxicity and the process is probably mediated through its antioxidant properties.     

Higher education strategy in digital transformation

Education and Information Technologies - Digital transformation in the global higher education industry determines the future roadmap to a sustainable education management strategy. This research...     

Circulating vascular endothelial growth factor and nitric oxide in patients with liver cirrhosis: A possible association with liver function impairment

Hemodynamic disorders of liver cirrhosis complicated with portal hypertension are associated with an increased angiogenesis in animal model of portal hypertension and cirrhosis which were linked to increased expression of vascular endothelial growth factor (VEGF) and nitric oxide (NO). The aim of study was to evaluate the serum concentration of VEGF and total nitric oxide (NO) in liver cirrhosis and the possible association with the degree of liver insufficiency. VEGF and NO were measured in serum of 64 patients with liver cirrhosis by ELISA and spectrophotometry respectively. The significant increase of serum VEGF was observed in liver cirrhosis compared to healthy individuals as well as serum NO (106.1 ± 66.7 vs. 41.5 ± 6 pg/mL, P < 0.05; 113.5 ± 65.8 vs. 20.8 ± 3.8 μmol/l, P< 0.001, respectively). Serum VEGF and NO showed significant associations with biochemical indices of liver function and with Child-pugh score where they were increased respectively to the degree of liver insufficiency. A significant association of raised serum NO in early stage of portal hypertension reflect its benefit in early expect of portal hypertension but, high serum VEGF in late stage may reflect its prognostic value in liver cirrhosis.     

Robust integral backstepping control for sensorless IPM synchronous motor controller

In this paper, a sensorless speed control for interior permanent magnet synchronous motors (IPMSM) is designed by combining a robust backstepping controller with integral actions and an adaptive interconnected observer. The IPMSM control design generally requires rotor position measurement. Then, to eliminate this sensor, an adaptive interconnected observer is designed to estimate the rotor position and the speed. Moreover, a robust nonlinear control based on the backstepping algorithm is designed where an integral action is introduced in order to improve the robust properties of the controller. The stability of the closed-loop system with the observer–controller scheme is analyzed and sufficient conditions are given to prove the practical stability. Simulation results are shown to illustrate the performance of the proposed scheme under parametric uncertainties and low speed. Furthermore, the proposed integral backstepping control is compared with the classical backstepping controller.     

Hybrid sliding mode observer for switched linear systems with unknown inputs

This paper addresses the state observation and unknown input estimation of a class of switched linear systems with unknown inputs. This class of systems may have modes in which the state is not fully observable. A state transformation allows implementing two suitable reduced-order observers. The first one, based on second order sliding mode techniques, is proposed to reconstruct the discrete state in the presence of unknown inputs. The second one, based on gathering partial information from individual modes of the switched system and on higher order sliding mode techniques, is introduced to estimate the continuous state. Then, the observer injection signal of the first second order sliding mode observer is used to estimate the unknown inputs. Simulation results highlight the efficiency of the proposed method.     

Preparing teachers for a mobile world,to improve access to education

Recent statistics on the use of mobile technology proclaim that the world is becoming mobile. People use their phones to socialize, to conduct business, to search for information, and more. For the first time in history, people around the world have the potential to learn from any location at their own convenience. But first, education systems must change, to facilitate mobile access to education. As this article describes, the most important change will be training teachers, both in pre-service programmes and through professional development, to use the technology to design and deliver education and to create bridges to informal learning. The article also describes some projects around the world that are helping to prepare teachers for the mobile world, and some pilot projects using the technology. Most such research, however, is limited to short-term studies focusing on learners’ satisfaction with mobile learning. Future studies must consider its long-term benefits and its impacts on performance and retention. As mobile technologies emerge, teachers have to keep up with the changes so that they can take advantage of the power of the technology to design and deliver education.