Protective effect of ascorbic acid against oxidative damage induced by hydrogen peroxide in cultured human peripheral blood lymphocytes

Hydrogen peroxide is one of the reactive oxygen species for cellular injury. It is overproduced during oxidative stress and is known to damage proteins, nucleic acids and cell membranes. The present study was aimed to study the protective effect of ascorbic acid against the toxic doses of hydrogen peroxide using lipid peroxidation and cytokinesis blocked micronucleus assay. Hydrogen peroxide was studied at 50, 100 and 200μM and was found to increase a dose dependent increase in lipid peroxidation and micronuclei frequency. The treatment of 100 and 200μM of hydrogen peroxide separately along with 20, 40 and 80μM of ascorbic acid showed a dose dependent decrease in the lipid peroxidation and micronuclei frequency. The results suggest a protective effect of ascorbic acid against the hydrogen peroxide induced oxidative damage in cultured human peripheral blood lymphocytes.     

Changing Attitudes to University Mathematics Through Problem Solving

University mathematics is often presented in a formal way that causes many students to cope by memorising what they perceive as a fixed body of knowledge rather than learning to think for themselves. This research studies the effects on students' attitudes of a course encouraging co-operative problem-solving and reflection on the thinking activities involved. The attitudinal questionnaire was shown to the students' teachers who were asked to specify the attitudes they expect from their students and the attitudes they prefer. This was used to give a ‘desired direction of change’ from expected to preferred. Before the course, half the students responded that university mathematics did not make sense. A majority declared negative attitudes such as anxiety, fear of new problems and lack of confidence. During the problem-solving course the changes were almost all in the desired direction. During the following six months of standard mathematics lecturing, almost all changes were in the opposite direction. This revised version was published online in July 2006 with corrections to the Cover Date.     

Yaffa: a school of their choice?

This article is a product of in‐depth research in Yaffa, The Arab Democratic School that was carried out in 2004/05, as part of a study on alternative Arab education in Israel. Its aim, beyond telling the story of Yaffa, is to explicate the motivations that underlay this initiative, and to examine parental choice amongst the disadvantaged. We ask how the Arabs’ parental choice is affected by their (marginalised) social location, by how far they are from the dominant culture, and by their (in)capacity to make a difference. Apparently, to make a choice is a multidimensional act, reflecting the Palestinian citizens’ resistance to their marginalisation and unwillingness to be subjugated through non‐democratic educational perceptions. Their positionality resonates in Yaffa, as an act of intervention, and their search for an alternative reality where democratic education is not and cannot be separated from the Palestinian citizens’ need to imagine themselves as Arabs.     

A new fabrication technique to form complex polymethylmethacrylate microchannel for bioseparation

Recent studies show that reduction in cross-sectional area can be used to improve the concentration factor in microscale bioseparations. Due to simplicity in fabrication process, a step reduction in cross-sectional area is generally implemented in microchip to increase the concentration factor. But the sudden change in cross-sectional area can introduce significant band dispersion and distortion. This paper reports a new fabrication technique to form a gradual reduction in cross-sectional area in polymethylmethacrylate (PMMA) microchannel for both anionic and cationic isotachophoresis (ITP). The fabrication technique is based on hot embossing and surface modification assisted bonding method. Both one-dimensional and two-dimensional gradual reduction in cross-sectional area microchannels were formed on PMMA with high fidelity using proposed techniques. ITP experiments were conducted to separate and preconcentrate fluorescent proteins in these microchips. Thousand fold and ten thousand fold increase in concentrations were obtained when 10 × and 100 × gradual reduction in cross-sectional area microchannels were used for ITP.     

Performance improvement of complementary feeders using static transfer switch system

The performance of complementary feeders, running in parallel, can be significantly improved by installing static transfer switches （STSs） at critical locations. We develop the STS control logic, which transfers the critical load from the preferred feeder to the alternate feeder when a voltage sag or a fault occurs on the preferred feeder. A forced commutation technique is proposed and implemented to turn off the preferred feeders＇ thyristor, thus avoiding cross current to flow and minimizing the transfer time. Simulation results show that the forced commutation technique is more effective as compared to the recently proposed time delay technique for STS operation. Two different feeders, namely New Exchange, the preferred feeder, and Sector 1-10/2, the alternate feeder of Islamabad Electric Supply COmpany （IESCO）, Pakistan, have been selected for case studies. The software PSCAD/EMTDC professional package has been used for simulation.     

Does performance in progressive assessment influence the outcome in final examination? An Australian experience

This paper investigates whether performance in progressive assessment necessarily influences the outcome in the end-of-semester final examination using the experience of an introductory postgraduate statistics course at a large Australian university. The average score on progressive assessments was higher than that of the final examination. Students attaining a higher distinction (HD) at the progressive assessment had a 37% chance of securing the same grade in the final examination, while students securing just a pass grade at the progressive assessment had 54 percent chance of failure in the final examination. Multiple regression analysis revealed that students’ performance in progressive assessments had a significant positive impact on final examination, so has the impact of learning diary. Mid-semester tests based exclusively on multiple choice questions (MCQs), more weights in progressive assessment and class-size appeared to have significant negative impact on the performance in the final examination. Focus group discussions suggest that (a) the final examination under timed conditions; (b) competing demands on time for final examination in other courses due contemporaneously; and (c) weaker motivation to sustain the momentum due to pass or near pass based on progressive assessments were the main hurdles in achieving better performance in the final examination.     

Impact of carbohydrate mouth rinsing on time to exhaustion during Ramadan: A randomized controlled trial in Jordanian men

Mouth rinsing using a carbohydrate (CHO) solution has been suggested to improve physical performance in fasting participants. This study examined the effects of CHO mouth rinsing during Ramadan fasting on running time to exhaustion and on peak treadmill speed (V_peak). In a counterbalanced crossover design, 18 sub-elite male runners (Age: 21?±?2 years, Weight: 68.1?±?5.7?kg, VO_2max: 55.4?±?4.8?ml/kg/min) who observed Ramadan completed a familiarization trial and three experimental trials. The three trials included rinsing and expectorating a 25?mL bolus of either a 7.5% sucrose solution (CHO), a flavour and taste matched placebo solution (PLA) for 10?s, or no rinse (CON). The treatments were performed prior to an incremental treadmill test to exhaustion. Three-day dietary and exercise records were obtained on two occasions and analysed. Anthropometric characteristics were obtained and recorded for all participants. A main effect for mouth rinse on peak velocity (V_peak) (CHO: 17.6?±?1.5?km/h; PLA: 17.1?±?1.4?km/h; CON: 16.7?±?1.2?km/h; P?η_p²?=?0.49) and time to exhaustion (CHO: 1282.0?±?121.3?s; PLA: 1258.1?±?113.4?s; CON: 1228.7?±?98.5?s; P?=?.002, η_p²?=?0.41) was detected, with CHO significantly higher than PLA (P?P?P?>?.05). Energy availability from dietary analysis, body weight, and fat-free mass did not change during the last two weeks of Ramadan (P?>?.05). This study concludes that carbohydrate mouth rinsing improves running time to exhaustion and peak treadmill speed under Ramadan fasting conditions.     

Crack Saturation as a Mechanism of Acclimatization of Panel Paintings to Unstable Environments

ABSTRACT

This paper analyzes the process of crack saturation, which is fundamental to understanding why panel paintings have survived remarkably well in the uncontrolled environments of historic houses or places of worship for several centuries. The process of crack saturation was analyzed using finite element modeling. A double layer elastic model with fractured overlying paint layer was subjected to uniaxial tension. The critical separation between cracks was determined and compared with patterns observed in real paintings. In addition, the generation and propagation of delamination were studied to elucidate the effect of their propagation on the saturation distance of cracks, as well as the load carrying ability of the paint layer. Contributing modes of crack propagation and their significance are also discussed. The results demonstrate that shearing fracture mode dominates the process of delamination. The impact of crack saturation on the degree of relative humidity variation that is allowable is also discussed.     

Lab-on-a-chip workshop activities for secondary school students

The ability to engage and inspire younger generations in novel areas of science is important for bringing new researchers into a burgeoning field, such as lab-on-a-chip. We recently held a lab-on-a-chip workshop for secondary school students, for which we developed a number of hands-on activities that explained various aspects of microfluidic technology, including fabrication (milling and moulding of microfluidic devices, and wax printing of microfluidic paper-based analytical devices, so-called μPADs), flow regimes (gradient formation via diffusive mixing), and applications (tissue analysis and μPADs). Questionnaires completed by the students indicated that they found the workshop both interesting and informative, with all activities proving successful, while providing feedback that could be incorporated into later iterations of the event.     

Implicit aspect extraction in sentiment analysis: Review,taxonomy, oppportunities,and open challenges

Sentiment analysis is a text classification branch, which is defined as the process of extracting sentiment terms (i.e. feature/aspect, or opinion) and determining their opinion semantic orientation. At aspect level, aspect extraction is the core task for sentiment analysis which can either be implicit or explicit aspects. The growth of sentiment analysis has resulted in the emergence of various techniques for both explicit and implicit aspect extraction. However, majority of the research attempts targeted explicit aspect extraction, which indicates that there is a lack of research on implicit aspect extraction. This research provides a review of implicit aspect/features extraction techniques from different perspectives. The first perspective is making a comparison analysis for the techniques available for implicit term extraction with a brief summary of each technique. The second perspective is classifying and comparing the performance, datasets, language used, and shortcomings of the available techniques. In this study, over 50 articles have been reviewed, however, only 45 articles on implicit aspect extraction that span from 2005 to 2016 were analyzed and discussed. Majority of the researchers on implicit aspects extraction rely heavily on unsupervised methods in their research, which makes about 64% of the 45 articles, followed by supervised methods of about 27%, and lastly semi-supervised of 9%. In addition, 25 articles conducted the research work solely on product reviews, and 5 articles conducted their research work using product reviews jointly with other types of data, which makes product review datasets the most frequently used data type compared to other types. Furthermore, research on implicit aspect features extraction has focused on English and Chinese languages compared to other languages. Finally, this review also provides recommendations for future research directions and open problems.