New age adjuvants and delivery systems for subunit vaccines

The dramatic advancements in the field of vaccinology has led to the formulation of chemically well defined vaccines composed of synthetic peptides and recombinant proteins derived from the immunologically dominant regions of the pathogens. Though these subunit vaccines are safer compared to the traditional vaccines they are known to be poorly immunogenic. This necessitates the use of adjuvants to enhance the immunogenicity of these vaccine formulations. The most common adjuvant for human use is alum. Research in the past has focused on the development of systemic immunity using conventional immunization protocols. In the present are, the emphasis is on the development and formulation of alternative adjuvants and delivery systems in generating systemic as well as mucosal immunity. This review mainly focuses on a variety of adjuvants (particulate as well as non-particulate) used with protective antigens of HIV, malaria, plague, leprosy using modified delivery vehicles. The experience of our laboratory and other researchers in this field clearly proves that these new age adjuvants and delivery systems undoubtedly generate enhanced immune response-both humoral and cell mediated. The choice of antigens, the nature of adjuvant used and the mode of delivery employed have a profound effect on the type of immune response generated. Besides the quantity, the quality of the antibodies generated also play a vital role in protection against these diseases. Some of the adjuvants and delivery systems used promoted high titre and affinity antibodies, which were shown to be cytophilic in nature, an important criteria in providing protection to the host. Thus the studies on these adjuvants/delivery systems with respect to various infectious diseases indicate their active role in efficient modulation of immune response along with safety and permissibility.     

Evidence for color vision in procyonides: Comparison between diurnal coatis (Nasua) and nocturnal kinkajous (Potos flavus)

The color-vision capacity of two species of procyonides was analyzed using a binary simultaneous discrimination paradigm. To make hue the only salient cue, the color sets of red, yellow, green, and blue were each presented in five different saturation intervals and were tested against a variety of brightness steps. Unlike the nocturnal kinkajous, the diurnal coatis showed highly significant discriminative performance on the color problems, especially in tests on blue and yellow, yet failed to differentiate unsaturated green from achromatic stimuli. The results are discussed with respect to procedural variables and the utility of color discrimination in the coati’s natural environment.     

High-Ability Grouping: Benefits for Gifted Students’ Achievement Development Without Costs in Academic Self-Concept

Effects of full-time ability grouping on students’ academic self-concept (ASC) and mathematics achievement were investigated in the first 3 years of secondary school (four waves of measurement; students’ average age at first wave: 10.5 years). Students were primarily from middle and upper class families living in southern Germany. The study sample comprised 148 (60% male) students from 14 gifted classes and 148 (57% male) students from 25 regular classes (matched by propensity score matching). Data analyses involved multilevel and latent growth curve analyses. Findings revealed no evidence for contrast effects of class-average achievement or assimilation effects of class type on students’ ASC. ASC remained stable over time. Students in gifted classes showed higher achievement gains than students in regular classes.     

Stress-related psychological factors for back pain among athletes: Important topic with scarce evidence

Health issues represent a frequent problem for athletes, as this particular demographic is repeatedly confronted with physically and psychologically stressful situations. Back pain (BP) materialises as comparatively common health problem being regarded as functionally limiting and psychologically straining burden for athletes. According to research conducted on athletes with BP, biomechanical and physiological mechanisms emerge as influential, whereas stress-related psychological factors appear to be neglected. For athletic injuries, the essential impact of psychological processes on injury occurrence and return from injury has already been corroborated. Hence, the aim of this literature review is to: (1) introduce a conceptual differentiation between injuries and BP; (2) summarise the results obtained regarding stress-related psychological aspects for injuries; and (3) connect the injury research to the state-of-the-art evidence regarding stress-related factors for BP among athletes. A distinction between injuries and BP could be established based on previous definitions, despite the fact that a considerable overlap between both concepts prevails. Injuries can be attributed to a physical origin, whereas BP frequently lacks this physical criterion. For BP, our enquiry yielded four studies including psychological measures of stress – with two studies specifically examining the association between BP and psychological stress among athletes longitudinally. Abundant findings from the general population support the importance of considering psychological and specifically stress-related factors in BP prevention and rehabilitation, but evidence related to the athletic field remains elusive. Further scientific investigations with a wider methodological approach are needed to deepen the knowledge about the crucial relationship between psychological stress, BP, and athletes.     

A model for exercise behavior change regulation in patients with heart disease

Despite the known benefits of habitual exercise in patients with heart disease, less than half of these patients exercise regularly and many of those who initiate programs fail to maintain physical activity routines over the long term. The aim of this research was to examine processes related to short- and long-term regulation of exercise to gain a clearer understanding of why people might fail to maintain intended behavioral changes. We modeled intention formation and plan formulation to investigate the distinct roles of self-efficacy and motivation (self-determination) in different phases of behavior change. Our results showed self-efficacy to be more relevant to exercise intentions and motivation to exercise planning. This research provides evidence supporting the proposition that the psychological processes related to short- and long-term regulation of behavior change differ and suggests that people might fail to continue regulating intended behavior owing to a lack of self-determined motivation.     

Salivary Testosterone Levels in Intellectually Gifted and Non-Intellectually Gifted Preadolescents: An exploratory study

There are suggestive data to link salivary testosterone concentrations (ST) to cognitive abilities in humans. Saliva reflects the plasma-free fraction of ST, which is biologically active, available for uptake by tissues including the brain. In the present study, therefore, salivary testosterone levels in healthy preadolescent children of both sexes, 6 to 9 years old, were determined. Among a total of 215 participants, 122 were intellectually gifted, attending special classes for gifted in primary school (IQ 130 or more in two independent standard tests of general intelligence). Their ST levels were compared with ST levels of 93 non-gifted children attending regular primary school. In general, results show there are no changes in ST concentrations between ages 6 and 9. However, there are significant differences between gifted and non-gifted participants. ST levels in gifted children were lower (p < 0.01) in all age categories. This also holds for both sexes separately (p < 0.01).