利用基于Mashup的轻量级应用集成框架构建数字图书馆门户

设计并实现一个基于Mashup技术的轻量级应用集成框架,该框架采用前端MVC模式以及服务组件架构,具有轻量级、易扩展以及松耦合集成的特点。在该框架的基础上构建数字图书馆门户,实际测试表明该门户系统运行效率高,能快速、低代价地整合各类分布环境下的异构资源。对于中小型图书馆,该解决方案具有较为普遍的适用性。     

图书馆权利冲突论——一个微观的视角

图书馆权利冲突日益泛化并为学界所关注,图书馆权利冲突中的"权利"应为正当权利、法定权利并受平等保护。从微观视角,图书馆权利冲突既可以发生在不同的主体之间,也可以依内容作不同的分类,权利冲突的实质其实是利益和价值冲突,应采用利益衡量的原则来解决图书馆权利冲突。     

数字时代政府信息公开目录服务体系建设研究

政府信息公开目录服务体系的建设在国内和国外都是一个新事物,本文对国内外政府信息公开目录服务体系的建设进行了概述,指出了国内一些政府信息公开目录存在的问题,提出了我国政府信息公开目录服务体系的改进方法和完善措施。     

高校图书馆矩阵式业务管理模式探析

本文对我国高校大多数图书馆现行的管理模式进行了剖析,提出了纵横结合的矩阵式业务管理模式是高校图书馆管理发展的方向,分析了这种新型管理模式的优越之处,并对如何控制其工作质量,提高工作效率和保持工作的连续性提出了自己的见解。     

Effect of Vitamin E on sP-Selectin Levels in Pre-Eclampsia

P-selectin, a cell adhesion molecule is elevated in many inflammatory conditions including preeclampsia which is characterized by generalized endothelial dysfunction and vasoconstriction presumably due to free radicals or mediators released by defective placentation. Vitamin E has been documented to protect cell membranes from oxidative damage and also decrease platelet aggregation. The role of vitamin E in pre-eclampsia is contradictory and hence the study was undertaken. Soluble P-selectin was measured by ELISA and Vitamin-E levels in plasma was estimated spectrofluorometrically. In our study the effect of supplementation of 400 IU/day of Vitamin E (a-tocopheryl acetate) to patients of pre-eclampsia showed significant decreased levels of soluble P-selectin by 2nd week as compared to patients given placebo (P = 0.005). In this short period of study no direct correlations were observed between Vitamin E or P-selectin levels with blood pressure as well as with proteinuria. Future studies may focus on the effect of a-tocopheryl acetate or the phosphate form of Vitamin-E, recently proposed to be the more active form on other inflammatory markers like IL-6, an important stimuli of P-selectin release in pre-eclampsia.     

Role of Plasma MMP 9 levels in the Pathogenesis of Chronic Pancreatitis

Pancreatic fibrosis is a key pathological feature in the etiology of chronic pancreatitis that leads to obliteration of exocrine and endocrine pancreatic tissues and its replacement by fibrous tissue resulting in clinical manifestations. Matrix metalloproteinase 9 is a member of the MMP family that is also known as gelatinase B, degrades type IV collagen of extracellular matrix and basal membrane. The present study is aimed at evaluating the clinical significance of plasma concentration of MMP-9 in chronic pancreatitis. The samples were obtained from 112 chronic pancreatitis patients and an equal number of age and sex matched healthy controls. MMP-9 levels were quantitatively measured by ELISA assay. Statistical analysis was applied to test the significance of results. The present study revealed a significant increase of plasma MMP 9 levels in chronic pancreatitis patients compared to control subjects. Elevated levels were also observed in all the patient groups compared to control subjects with regard to sex, age, addictions etc. MMP-9 degrades the type IV collagens in normal basement membrane, which in turn activates the pancreatic stellate cells which promote the development of pancreatitic fibrosis. Thus, elevated plasma levels of MMP-9 may act as a susceptibility factor for the development of chronic pancreatitis.     

重庆第三产业R&D投入产出效应的实证研究

本文构建了二级三要素CES生产函数,把要素投入分为R&D投入与非R&D投入两个部分,计算了重庆第三产业五个主要行业的R&D投入与非R&D投入的替代弹性和产出弹性。研究发现这些行业目前都处于规模报酬递增阶段,人力投入与资本投入之间的替代弹性平均约为1,R&D资本投入替代弹性比R&D人力投入替代弹性小,非R&D投入的产出弹性高于R&D投入的产出弹性。最后根据研究结论提出了对策建议。     

Organic Acidurias: An Updated Review

Organic acidurias are an important class of inherited metabolic disorders arising due to defect in intermediary metabolic pathways of carbohydrate, amino acids and fatty acid oxidation. This review summarizes the current knowledge about the important organic acidurias in the Indian population. Specifically, diagnosis and principles of treatment of organic acidurias are covered. The salient features of common organic acidurias as well as their prevalence in various parts of the world are reviewed in some detail.     

Profile of Plasma Amino Acid Levels in Rats Exposed to Acute Hypoxic Hypoxia

The effect of acute hypoxic hypoxia on the profile of plasma amino acids in rats was studied and compared to that resulting from acute liver injury induced by giving carbon tetrachloride. In hypoxic rats exposed to 45% air in N₂ for 5 h, the concentrations of branched chain amino acids, including valine, leucine and isoleucine, and aromatic amino acids such as phenylalanine and tyrosine were significantly increased as compared to those in normoxic rats. The ratio of branched-chain to aromatic amino acids (Fischer’s ratio) was significantly decreased. The levels of arginine and citrulline, which are related to the urea cycle, were also depressed. Furthermore, plasma proline level was reduced in hypoxic rats. The activities of plasma marker enzymes for tissue damage remained unchanged during hypoxia, indicating that tissue injury was not induced by exposure to hypoxic conditions. We suggest that the characteristic profile of plasma amino acids and the Fischer ratio are valuable tools for understanding the pathology of acute hypoxia in the absence of systemic tissue damage.