Evaluation of polymerase chain reaction for rapid diagnosis of clinically suspected tuberculous pleurisy

Pleural effusion is one of the commonest presentations of tuberculosis, the clinical manifestations being typically abrupt resembling bacterial pneumonia. Since delayed hypersensitivity is the underlying immune response, bacterial load is very low. Owing to these facts, tuberculous pleurisy as an extra-pulmonary disease poses a diagnostic dilemma. The conventional bacteriological methods rarely detect Mycobacterium tuberculosis in pleural fluid and are of limited use in diagnosis of tuberculous pleurisy. We evaluated the efficacy of polymerase chain reaction (PCR) in the diagnosis of tuberculous pleurisy by targeting the gene segment coding for MPB64 protein specific forMycobacterium tuberculosis. Based on the clinical criteria, 82 patients with lymphocytic exudative pleural effusion were included in the study. Patients were analyzed in two groups; one group consisting of 48 patients of tubercular pleural effusion confimed by various diagnostic procedures and another group of 34 patients comprising of non-tubercular pleural effusion. There were no false positive results by PCR and the specificity worked out to be 100%. Twenty two patients tested positive for Mantoux with a sensitivity of 45%. ZN-staining for AFB was found in samples from 15 patients (20% sensitivity). ADA was positive for 28 patients with a sensitivity of 53%. PCR was positive for 32/48 patients (67% sensitivity). Thus, PCR was found to be more sensitive than any other conventional method in diagnosis of clinically suspected tubercular pleurisy.     

魅力巴基斯坦

巴基斯坦的自然风光十分壮美,地形地势丰富多样。这里有皑皑白雪覆盖的群山,有激流缓滩、广袤的森林、一望无垠的沙漠和众多郁郁葱葱的山谷。在巴基斯坦长达900公里的海岸线上,海水清澈见底,沙滩十分干净,岸边阳光明媚、天蓝云淡,是令人向往的旅游胜地。巴基斯坦还有辉煌的艺术品和建筑物、古老的珍宝、迷人的文化、传统的节日、引以自豪的宫殿、阔绰的皇家公园,     

Textual keyword extraction and summarization: State-of-the-art

With the advent of Web 2.0, there exist many online platforms that results in massive textual data production such as social networks, online blogs, magazines etc. This textual data carries information that can be used for betterment of humanity. Hence, there is a dire need to extract potential information out of it. This study aims to present an overview of approaches that can be applied to extract and later present these valuable information nuggets residing within text in brief, clear and concise way. In this regard, two major tasks of automatic keyword extraction and text summarization are being reviewed. To compile the literature, scientific articles were collected using major digital computing research repositories. In the light of acquired literature, survey study covers early approaches up to all the way till recent advancements using machine learning solutions. Survey findings conclude that annotated benchmark datasets for various textual data-generators such as twitter and social forms are not available. This scarcity of dataset has resulted into relatively less progress in many domains. Also, applications of deep learning techniques for the task of automatic keyword extraction are relatively unaddressed. Hence, impact of various deep architectures stands as an open research direction. For text summarization task, deep learning techniques are applied after advent of word vectors, and are currently governing state-of-the-art for abstractive summarization. Currently, one of the major challenges in these tasks is semantic aware evaluation of generated results.     

The politics of mourning in Cyprus and Israel: educational implications

This paper suggests the need for a critical analysis of the nationalization of mourning and its educational implications, especially in conflict‐ridden areas. Our thoughts are grounded in a comparative study on mourning that has been conducted as part of our long‐standing ethnographic research in schools in Cyprus and Israel during the last 10 years. Through this study on mourning, we highlight two ideas. First, we want to show how a comparison of our studies in Cyprus and Israel highlights the difficulties for alternative interpretations to be translated into educational policies and teacher practices in the absence of changes in political structures. Second, we want to show that despite the forces that nationalize mourning, there are educational openings for alternative interpretations about mourning and the encouragement of reconciliation pedagogies. To this end, the education literature on teaching controversial issues and examples of pedagogies for reconciliation might be relevant to provide concrete ideas for education theory, policy and practice on issues of mourning.     

The "geography" of child maltreatment in Israel: Findings from a national data set of cases reported to the social services

OBJECTIVES: This article examines the "geography" of reported cases of child maltreatment in Israel by determining its frequency and rates according to nationality, area of residence, and size and type of locality. METHOD: The study collected data at the local level in Israel based on reports to social services of cases of child maltreatment during 2000; locality is the unit of analysis. RESULTS: The rate of reported cases of child maltreatment was 17.8 per 1,000 children in Israel in 2000. The rates varied, however, among different localities. They were lower in Arab localities (9 per 1,000 children) than in the Jewish ones (20 per 1,000), higher in large cities and other socioeconomic affluent localities (19 per 1,000), and varied according to the geographic area. CONCLUSIONS: This study demonstrates considerable variation in rates of reported cases of child maltreatment by locality and by population makeup. Thus, to fulfill the Israeli legislation of mandatory reporting of any reasonable suspicion of child maltreatment, the state should better develop policies and services that encourage reporting of child maltreatment among the Arab and ultraorthodox populations and in smaller or socioeconomic disadvantaged localities. Furthermore, the social services must build a bridge to the minority populations in Israel, developing their trust in these services and increasing their propensity to use them.     

ISPCAN Child Abuse Screening Tool Children's Version (ICAST-C): Instrument development and multi-national pilot testing

ObjectiveTo develop a child victimization survey among a diverse group of child protection experts and examine the performance of the instrument through a set of international pilot studies.MethodsThe initial draft of the instrument was developed after input from scientists and practitioners representing 40 countries. Volunteers from the larger group of scientists participating in the Delphi review of the ICAST P and R reviewed the ICAST C by email in 2 rounds resulting in a final instrument. The ICAST C was then translated and back translated into six languages and field tested in four countries using a convenience sample of 571 children 12–17 years of age selected from schools and classrooms to which the investigators had easy access.ResultsThe final ICAST C Home has 38 items and the ICAST C Institution has 44 items. These items serve as screeners and positive endorsements are followed by queries for frequency and perpetrator. Half of respondents were boys (49%). Endorsement for various forms of victimization ranged from 0 to 51%. Many children report violence exposure (51%), physical victimization (55%), psychological victimization (66%), sexual victimization (18%), and neglect in their homes (37%) in the last year. High rates of physical victimization (57%), psychological victimization (59%), and sexual victimization (22%) were also reported in schools in the last year. Internal consistency was moderate to high (alpha between .685 and .855) and missing data low (less than 1.5% for all but one item).ConclusionsIn pilot testing, the ICAST C identifies high rates of child victimization in all domains. Rates of missing data are low, and internal consistency is moderate to high. Pilot testing demonstrated the feasibility of using child self-report as one strategy to assess child victimization.Practice implicationsThe ICAST C is a multi-national, multi-lingual, consensus-based survey instrument. It is available in six languages for international research to estimate child victimization. Assessing the prevalence of child victimization is critical in understanding the scope of the problem, setting national and local priorities, and garnering support for program and policy development aimed at child protection.     

Anatomy "steeplechase" online: necessity sometimes is the catalyst for innovation

In most medical schools, summative practical examination in Anatomy usually takes the format of a “steeplechase” (“spotters” or “bell ringers”) conducted in the gross anatomy laboratory using cadaveric material and prosected specimens. Recently, we have started to administer similar examinations online using the quiz facility in WebCT? and Moodle?. This article chronicles how we conceived and developed this method within the peculiar nature of our medical school setting. Over a five year period, practical summative examinations were organized as “steeplechase” online. The online examinations were administered using WebCT? and later Moodle? learning management software. Assessment “objects” were created from the materials available for anatomy teaching. These were digital images of cadaveric materials, radiological, and prosected specimens. In addition, short video clips of 30 seconds duration demonstrating muscle action were produced. These objects were optimized for online viewing and then uploaded onto the learning management software. A bank of questions (multiple choice or short answer type) was then created and linked to the assessment objects. These were used in place of the steeplechase in the computer laboratory. This method serves a crucial purpose in places like ours where continuous availability of human cadavers is impossible. Although time consuming initially, once questions are setup online, future retrieval, and administration becomes convenient especially where there are large batches of students. In addition, the online environment offers distinct advantages with regards to image quality, psychometric analysis of the examination and reduction of staff preparation time compared to traditional “steeplechase.” Anat Sci Educ 4: 115–118, 2011. © 2010 American Association of Anatomists.