The IR Has Two Faces: Positioning Institutional Repositories for Success

This article describes the ongoing efforts at University of Nevada, Las Vegas (UNLV) Libraries to evolve the role of the institutional repository (IR) and to effectively position it within the context of the Libraries’ collections, research support, and scholarly communication services. A major component of this process is re-examining the fundamental aims of the IR and aligning it to the Libraries and the campus strategic goals. The authors situate UNLV Libraries’ experience within the context of the current literature to provide background and reasoning for our decision to pursue two, at times conflicting, aims for the IR: one for scholarly communication and another for research administration.     

Citizen-Centered Journalism and Contested Boundaries

This article explores the existence of a “citizen-centered journalism” that sees citizens as crucial participants in the construction of news and as co-creators of their own worlds. Through qualitative case studies of three news organizations, the article examines the motivation for using a citizen-centered approach, the news routines that are required to do so, the categories of content produced, and the perceived impact of this approach. The results suggest these news organizations are working in partnership with communities and striving to give a voice to historically marginalized communities. The journalists, however, see citizen participation as complementary to professional journalistic routines that favor verifiable information, rather than assigning inherent value to it for its own sake.     

Effects of purposeful soccer heading on circulating small extracellular vesicle concentration and cargo

BackgroundConsidering the potential cumulative effects of repetitive head impact (HI) exposure, we need sensitive biomarkers to track short- and long-term effects. Circulating small extracellular vesicles (sEVs) (<200 nm) traffic biological molecules throughout the body and may have diagnostic value as biomarkers for disease. The purpose of this study was to identify the microRNA (miRNA) profile in circulating sEVs derived from human plasma following repetitive HI exposure.MethodsHealthy adult (aged 18–35 years) soccer players were randomly assigned to one of 3 groups: the HI group performed 10 standing headers, the leg impact group performed 10 soccer ball trapping maneuvers over 10 min, and the control group did not participate in any soccer drills. Plasma was collected before testing and 24 h afterward, and sEVs were isolated and characterized via nanoparticle tracking analysis. Next-generation sequencing was utilized to identify candidate miRNAs isolated from sEVs, and candidate microRNAs were analyzed via quantitative polymerase chain reaction. In silico target prediction was performed using TargetScan (Version 7.0; targetscan.org) and miRWalk (http://mirwalk.umm.uni-heidelberg.de/) programs, and target validation was performed using luciferase reporter vectors with a miR-7844-5p mimic in human embryonic kidney (HEK) 293T/17 cells.ResultsPlasma sEV concentration and size were not affected across time and group following repetitive HI exposure. After 24 h, the HI read count from next-generation sequencing showed a 4-fold or greater increase in miR-92b-5p, miR-423-5p, and miR-24-3p and a 3-fold or greater decrease in miR-7844-5p, miR-144-5p, miR-221-5p, and miR-22-3p. Analysis of quantitative polymerase chain reaction revealed that leg impact did not alter the candidate miRNA levels. To our knowledge, miR-7844-5p is a previously unknown miRNA. We identified 8 miR-7844-5p mRNA targets: protein phosphatase 1 regulatory inhibitor subunit 1B (PPP1R1B), LIM and senescent cell antigen-like domains 1 (LIMS1), autophagy-related 12 (ATG12), microtubule-associated protein 1 light chain 3 beta (MAP1LC3B), integrin subunit alpha-1 (ITGA1), mitogen-activated protein kinase 1 (MAPK1), glycogen synthase kinase 3β (GSK3β), and mitogen-activated protein kinase 8 (MAPK8).ConclusionCollectively, these data indicate repetitive HI exposure alters plasma sEV miRNA content, but not sEV size or number. Furthermore, for the first time we demonstrate that previously unknown miR-7844-5p targets mRNAs known to be involved in mitochondrial apoptosis, autophagy regulation, mood disorders, and neurodegenerative disease.     

EUROPEAN PUBLIC PERCEPTIONS OF SCIENCE

In this paper we explore the relationships between public interestin, knowledge of, and attitudes towards science and technologyand the level of industrialization in 12 countries of the EuropeanCommunity. Using the 1989 Eurobarometer survey no 31 (N=11,678),we constructed four scales measuring interest, knowledge, generalattitudes to science, and support for EC funded science foreach of the 12 EC countries. We found that overall factual scientificknowledge correlates moderately positively with interest andattitudes to science. For example the Netherlands and GreatBritain have relatively high levels of knowledge, interest,and support for science in general. Spain and Greece have relativelylow levels of knowledge, interest, and support for science ingeneral. However, the simple correlation hides more complexrelationships. First, the variance within and across countriesof knowledge, attitudes and interest increases with nationallevels of knowledge. This indicates greater degrees of polarizationof both support and interest. Second, the data indicates a post-industrialismeffect: knowledge, interest in, and attitudes to science showa curvilinear relationship with levels of industrialization.The decline of interest in science and the less positive attitudesin highly developed countries requires further exploration.Third, we found, that the consistency of the knowledge and theattitude measures declines as the national level of knowledgeincreases. We suggest that this reflects a knowledge-ignoranceparadox and knowledge specialization among informed populations.Support for EC level science follows a different pattern. Wefound that France, Italy, and Spain show high levels of supportfor EC level science. This is not the case in Great Britainand Germany. The pattern suggests that attitudes towards ECscience are formed on the basis of national level scientificstrength: if the national science base is strong, EC scienceinitiatives find less support and vice versa. These findingsrepresent a first step towards a comparative assessment of publicunderstanding of science in EC countries.     

Water-clocks and time measurement in classical antiquity

The water-clock was the first mechanical device for time measurement to be used by the Greeks. Previously they had relied on sundials, or observation of the phases of the moon or the position of the sun in the zodiac to locate points of time within the day, month or year; and by the mid-fifth century BC they had made some progress with the difficult calendar problems due to the fact that the solar day, the lunar month, and the solar year are not commensurable with each other in whole numbers.