Evaluation of Oxidative Stress and DNA Damage in Benign Prostatic Hyperplasia Patients and Comparison with Controls

In the present study, oxidative stress and lymphocytic DNA damage in both pre-op and post-op benign prostrate hyperplasia (BPH) patients with age >50 years was evaluated and compared with normal healthy subjects (controls- without any evidence of disease) of the same sex and age group. From December 2007 to November 2009, oxidative stress in 45 BPH patients were evaluated both before (pre-op patients) and after 7 days of surgery (post-op patients) in terms of measurements of plasma levels of (1) various anti-oxidative enzymes, (2) non-enzymatic antioxidants and (3) malondialdehyde which is a product of lipid peroxidation. The lymphocyte DNA damage was also evaluated by single cell alkaline gel electrophoresis in terms of tail length migration in these patients. These values were compared with their respective control subjects of similar sex and age group. The activities of antioxidant enzymes and the levels of antioxidant, reduced glutathione were found significantly decreased (p < 0.05) in serum samples of pre-operative group of BPH patients as compared to the controls. These altered parameters increased significantly (p < 0.05) and returned to their near normal control values, but not up to baseline values, in post operative patients i.e. after the cancer load was decreased by surgery. Lymphocytic DNA damage was found to be significantly increased in pre-op group as compared to controls and was reduced after surgery in post-op group. The present study therefore, shows significantly increased levels of oxidative stress and DNA damage in BPH patients which were reduced after removal of tumour load. Thus oxidative damage plays an important role in prostate tumourogenesis and timely management of oxidative stress can be of importance in preventing the occurrence of BPH.     

The Role of the Community College in Providing Language,Speech, and Hearing Services

Abstract

A survey of community college personnel in Connecticut, New York, and New Jersey was conducted to determine (1) the extent and type of services in speech, hearing, or language screening, remediation, and improvement, (2) the extent and type of instruction in speech and language improvement, and (3) the extent and type of bilingual services in speech, hearing or language presently offered to students and community members within the community college setting. In addition, the existence of plans to offer these services in the future was ascertained. Responses indicated the existence of some services but a general unavailability of comprehensive screening, evaluation, and rehabilitation programs despite the widespread needs of the growing community college constituency. The results of the survey can assist community college personnel in needs assessment and planning within their own institutions by offering a context for consideration of the priority for providing language, speech, and hearing services within the community college setting.