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21.
Reduced hepatic lactate elimination initiates blood lactate accumulation during incremental exercise. In this study, we wished to determine whether renal lactate elimination contributes to the initiation of blood lactate accumulation. The renal arterial-to-venous (a-v) lactate difference was determined in nine men during sodium lactate infusion to enhance the evaluation (0.5 mol x L(-1) at 16 ± 1 mL x min(-1); mean ± s) both at rest and during cycling exercise (heart rate 139 ± 5 beats x min(-1)). The renal release of erythropoietin was used to detect kidney tissue ischaemia. At rest, the a-v O(2) (CaO(2)-CvO(2)) and lactate concentration differences were 0.8 ± 0.2 and 0.02 ± 0.02 mmol x L(-1), respectively. During exercise, arterial lactate and CaO(2)-CvO(2) increased to 7.1 ± 1.1 and 2.6 ± 0.8 mmol x L(-1), respectively (P < 0.05), indicating a -70% reduction of renal blood flow with no significant change in the renal venous erythropoietin concentration (0.8 ± 1.4 U x L(-1)). The a-v lactate concentration difference increased to 0.5 ± 0.8 mmol x L(-1), indicating similar lactate elimination as at rest. In conclusion, a -70% reduction in renal blood flow does not provoke critical renal ischaemia, and renal lactate elimination is maintained. Thus, kidney lactate elimination is unlikely to contribute to the initial blood lactate accumulation during progressive exercise.  相似文献   
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Here, we explored the relationship between incline and start strategy during alpine skiing. Eight FIS skiers performed starts on a flat (3°) and steep (21°) incline employing five different strategies. Their times, trajectories and velocities were monitored with a GNSS system and video. A significant interaction was observed between slope incline and start strategy with respect to the skier’s exit velocity (p < 0.001, ?2p = 0.716), but not for the start section time (p = 0.732, ?2p = 0.037). On the almost flat incline, both section time (p = 0.022, ?2p = 0.438) and exit velocity (p < 0.001, ?2p = 0.786) were influenced significantly by start strategy, with four V2 skate-pushes being optimal. On the steep incline, neither section time nor exit velocity was affected significantly by start strategy, the fastest section time and exit velocity being attained with four and two V2 skate-pushes, respectively. In conclusion, these findings demonstrate that the start strategy exerts considerable impact on start performance on almost flat inclines, with strategies involving three or more V2 skate-pushes being optimal. In contrast, start performance on the steep incline was not influenced by strategy.  相似文献   
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Pay-for-performance schemes have become a widespread management strategy in the public sector. However, not much is known about the rationales that trigger the adoption of performance-related pay provisions. This article examines managerial and organisational features of university departments in Denmark that use publication incentive payments. Most often it is used when heads of department outside the humanities think it is a good idea to reward scholars financially for publications. In-depth analysis of the cases reveals, however, that department heads cannot simply be divided between ‘believers’ and ‘non-believers’. Almost half expressed confidence in that publication incentive payments motivate researchers to perform better, not because of the monetary reward, but because of the positive feedback signalled by the pay supplement.  相似文献   
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This article describes how a research–practice partnership has informed the iterative development of a web-mediated early childhood language and literacy professional development (PD) intervention. Funded through the Investing in Innovation (i3) program, this new PD model is based on an effective in-situ intervention. As we translated the face-to-face model into a largely web-mediated approach, we partnered with educators to ensure that the resulting intervention was feasible and effective in real-world classrooms serving children at risk. Specifically, an educator advisory board provided ongoing input about the PD. Further, pilot teachers completed the training and provided feedback through a survey about the usability and effectiveness of the training modules, coaching, and instructional strategies in classroom settings. Findings suggest that research–practice partnerships that gather teachers’ situated, comprehensive, and insightful perspectives can be invaluable in developing PD interventions. Collaboration between school districts and university researchers is essential in this iterative development process.  相似文献   
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Grounded in the pragmatics of human communication perspective, the current study examined how disagreements and emotion function across cultural context in resolving conflict. Specifically, the research effort developed the Intercultural Conflict Style (ICS) inventory, a 36-item measure of intercultural conflict resolution style based on two core dimensions: Direct vs. indirect approaches to dealing with disagreements and emotionally expressive vs. emotionally restrained patterns for dealing with the affective dimension of conflict interaction. Confirmatory factor analysis (CFA) found the proposed two-factor model was a good fit to the data. Analysis of the CFA findings identified a final set of 18 direct/indirect items and 18 emotional expressiveness/restraint items. The direct/indirect scale obtained a coefficient alpha of .73 and the emotional expressiveness/restraint scale achieved .85 reliability. Validity testing of the scales found no significant effects by gender, education or previous intercultural living experience. A theoretical framework for understanding differences in conflict resolution styles grounded in the development of this inventory, a practical, four-quadrant intercultural conflict resolution style model is proposed based on high/low levels of directness and high/low levels of emotional expressiveness: (1) discussion style (direct & emotionally restrained), (2) engagement style (direct & emotionally expressive), (3) accommodation style (indirect & emotionally restrained) and (4) dynamic style (indirect and emotionally expressive).  相似文献   
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In this article, grade point average (GPA) is considered a missing data technique for unavailable grades in school grade records. In Study 1, theoretical and empirical differences between GPA and seven alternative missing grade techniques were considered. These seven techniques are subject mean substitution, corrected subject mean, subject correlation substitution, regression imputation, expectation maximization algorithm imputation and two multiple imputation methods-stochastic regression imputation and data augmentation., The missing grade techniques differ greatly. Data augmentation and stochastic regression imputation appear to be superior as missing grade techniques. In Study 2, the completed grade records (observed and imputed values) were used in two prediction analyses of academic achievement. One analysis was based on unweighed grades, the other on weighed grades. In both analyses, alternative missing grade methods produced better and more consistent predictions. It is concluded that some alternative missing grade methods are superior to GPA.  相似文献   
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Krarup  Niels  Naeraa  Noe  Olsen  Christian 《Higher Education》1974,3(2):157-164
In the few available studies on the use of books in examinations, open-book tests have been found to reduce pre-test memorization and anxiety during examinations without affecting academic performance. However, these studies were made with students in non-book systems, whereas systems which allowed books in all exams might be thought likely to create a non-fact-learning attitude in students. The present study was undertaken in a book-allowing system with 120 students during a regular course in physiology at a medical school. Each group sat two parallel 60-item multiple choice tests and used books in one test but not in the other. The tests took place about four weeks prior to the final examination, which is of the same type as the experimental tests. Recall items could yield less than 15% of maximum points, so that interpretation and problem-solving items predominated. Total test points with and without books did not differ significantly. An analysis of variance showed that the effect of books on recall items was only slight and that the two tests varied in difficulty, in spite of efforts to secure equality.  相似文献   
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