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641.
642.
地方电视台的电视讲坛节目要想立足竞争日益激烈的电视节目市场,必须摆脱<百家讲坛>的影响,根据当地的经济文化特点和爱众需求实现创新与突破,找准定位、办出特色,才能获得自己的生存空间. 相似文献
643.
Ananth N. Rao J. Kavitha Minakshi Koch V. Suresh Kumar 《Indian journal of clinical biochemistry : IJCB》2009,24(3):215-222
Inherited metabolic disorders are a heterogeneous group of genetic conditions mostly occurring in childhood. They are individually
rare but collectively numerous, causing substantial morbidity and mortality. We have retrospectively reviewed a total of eight
hundred and sixty nine cases with different age groups that had been referred from several diagnostic centers and hospitals
of India to the Department of Metabolism in Narayana Hrudayalaya, as cases suspected with inborn errors of metabolism. Advanced
techniques applied were to diagnose the disorders of inborn errors of metabolism. Data analyzed indicates occurrence of several
metabolic disorders in our population. The need to screen for an inborn error of metabolism arises out of the fact that most
cases take to irreversible effects as time progress. Emphasis has to be laid on early detection and prompt management, which
could help in alleviating symptoms and preventing complications and consequent incapacitation. 相似文献
644.
Chethana Chetan Ashok Prabhu Vivian D'Souza Shrinivas B. Rao 《Indian journal of clinical biochemistry : IJCB》2000,15(1):17-21
Blood RBC's were used to study the role of polyamines, putrescine, spermidine and spermine individually as antioxidants against
the peroxidative action of H2O2 which leads to haemolysis of erythrocytes. Results indicated that putrescine did not act as antioxidant at all concentrations
used in our studies. However, spermidine and spermine suppressed peroxidative changes in RBC's due to the action of H2O2 and this suppression was greater with higher concentration of these individual polyamines used, separately. Further, all
the three polyamines decreased haemolysis of erythrocytes at all concentrations studied. The action of putrescine to suppress
haemolysis of RBC's without showing antioxidant property hypothetically suggests that these properties of respective polyamines
may have independent mechanism of action. 相似文献
645.
Surekha Bhat Guruprasad Rao K. Dilip Murthy P. Gopalakrishna Bhat 《Indian journal of clinical biochemistry : IJCB》2008,23(2):191-194
High ambient temperature has been reported to increase oxidative stress by increasing lipid peroxidation and decreasing antioxidant
defence in transition dairy cows. It is also known to cause an increase in plasma cortisol levels in goats, European hedgehog
and human volunteers. High levels of glucocorticoids have been reported to decrease blood glutathione and erythrocyte superoxide
dismutase activity in rats. Although institutional animal houses in research laboratories of developed countries maintain
animals in air-conditioned rooms at constant temperature, the same is not true of animal houses in the developing countries
especially those belonging to smaller institutions and this could affect the results of the experiments being conducted on
these animals. The present research study was done to assess the effects of seasonal variations on the status of erythrocyte
oxidative damage, antioxidant defence and plasma cortisol levels in adult female Wistar rats. Rats were kept in their home
cages and were left in non-air-conditioned procedure rooms in two different seasons, Hot season (March-May) and Cool season
(June to September). Erythrocyte Thiobarbituric acid reactive substances and plasma cortisol levels were significantly increased
in rats exposed to high ambient temperature and humidity of the hot season as compared to the rats of the cool season. Erythrocyte
reduced glutathione levels, erythrocyte glutathione peroxidase and superoxide dismutase activities were significantly decreased
in the hot season group of rats. The results of our experiments showed that exposure of adult female Wistar rats to high ambient
temperature and humidity of the hot season increases neuroendocrine stress, oxidative stress and decreases antioxidant defence
in them. 相似文献
646.
Shruti Mohanty W. Amruthlal G. C. Reddy G. Kusumanjali A. S. Kanagasabapathy Pragna Rao 《Indian journal of clinical biochemistry : IJCB》2008,23(3):279-282
The aim of this study is to delineate laboratory diagnostic strategies for subclinical hypothyroidism in patients who are
clinically symptomatic but may have a normal thyroid profile. Tri — iodothyronine (T3), thyroxine (T4), thyroid stimulating hormone (TSH) and anti thyroid peroxidase antibodies (anti-TPO) were estimated on fasting blood samples
from 99 patients using electrochemiluminescence methods on ELECSYS 1010 (Roche). 74% of study subjects had elevated anti-TPO
levels.61% patients had subclinical hypothyroidism. 45 of the 61 subclinical hypothyroid patients had elevated anti-TPO levels
(73%). This is an important finding suggesting an autoimmune etiology for subclinical thyroid dysfunction with a higher risk
of developing overt hypothyroidism. 相似文献
647.
Divya Mahajan Anju Jain Varsha Singh A. K. Jain G. R. K. Rao Gopal Nath 《Indian journal of clinical biochemistry : IJCB》2008,23(3):243-245
Helicobacter pylori remains a controversial organism with regards to humans, its epidemiology still unclear nearly two decades
after discovery. The present study was undertaken to estimate the prevalence of the organism in the gastrointestinal tract
in symptomatic and asymptomatic subjects to understand its precise natural history in India. A total of 154 specimens were
a part of the study. These included gastric biopsies from peptic ulcer disease and Non ulcer dyspepsia subjects, as visualized
on endoscopy, saliva and stool samples from apparently normal healthy adults. Nested polymerase chain reaction was performed
using the primers Hp1, Hp2, Hp3 targeting 16S rRNA gene. A prevalence of 65.1%, 100%, 66.7%, and 73.3% respectively was observed
by polymerase chain reaction. No association was observed between the H.pylori status and the disease condition of the patient. 相似文献
648.
Pragna Rao G. C. Reddy A. S. Kanagasabapathy 《Indian journal of clinical biochemistry : IJCB》2008,23(3):209-217
Chronic kidney disease is becoming a major health problem globally and in India an alarming number of about 8 million people
are suffering from this disease. Patients undergoing hemodialysis have a high prevalence of protein-energy malnutrition and
inflammation. As these two conditions often occur concomitantly in hemodialysis patients, they have been referred together
as ‘malnutrition-inflammation-atherosclerosis syndrome’ to emphasize the important association with atherosclerotic cardiovascular
disease. The three factors related to the pathophysiology in these patients are dialysis related nutrient loss, increased
protein catabolism and hypoalbuminemia. Inflammation in Chronic Kidney disease is the most important factor in the genesis
of several complications in renal disease. Pro-inflammatory cytokines like IL-1 and TNF-alpha play a major role in the onset
of metabolic alterations in Chronic Kidney disease patients. Atherosclerosis is a very frequent complication in uremia due
to the coexistence of hypertension, hyperhomocysteinemia, inflammation, malnutrition and increased oxidative stress, generation
of advanced glycation end products, advanced oxidation protein products, hyperlipidemia and altered structural and functional
ability of HDL. LDL-cholesterol, apolipoprotein (A), apolipoprotein (B), and Lp(a) are also associated with atherosclerosis.
Studies have now provided enormous data to enable the evaluation of the severity of malnutrition-inflammation-atherosclerosis
syndrome as well as effective monitoring of these patients. 相似文献
649.
K. Reshma A. V. Rao M. Dinesh D. M. Vasudevan 《Indian journal of clinical biochemistry : IJCB》2008,23(2):171-175
Oxidants (NADPH oxidase and myeloperoxidase) and antioxidants (GSH,GSH peroxidase, SOD and glucose 6 phosphate dehydrogenase,
that provides NADPH for antioxidants) were assayed in the neutrophils from oral cancer patients, in three stages viz, baseline
samples,15 days after radiation and 30 days following radiation. These samples were obtained from 2 groups of patients. Group
A that received radiation alone and Group B that received radiation and ocimum flavonoids,a radioprotector. The results showed
a significant fall in the SOD levels in the second follow up of group B.Glucose 6 phosphate dehydrogenase showed significant
increase only in the first follow up of patients who received Ocimum flavonoids. Except for these findings all other parameters
remained statistically nonsignificant. 相似文献
650.
T. Ramakrishna Rao 《Resonance》2000,5(4):85-90
The cause-effect relationship for a wide variety of biological processes from molecular to ecosystem levels can be described
by a curvilinear function called the rectangular hyperbola. Although a simple algebraic equation adequately describes this
curve, biological models have generated different equations incorporating biologically meaningful parameters. The Michelis-Menten
equation describing enzyme kinetics, and the Type II functional response of predators to changing prey densities are two such
examples. 相似文献