Interrelationship Between Procalcitonin and Organ Failure in Sepsis

Sepsis suffers from lack of specific clinical symptoms which contribute to one of the major causes of mortality. In the present study, our aim was to evaluate the role of a recent biomarker Procalcitonin (PCT) in predicting organ dysfunction. 71 patients admitted with sepsis were included in the study. PCT levels were measured at 0, 24, 72 h and 7th day and sequential organ failure assessment score (SOFA) scores were calculated. PCT levels significantly decreased (p < 0.001) in 89.3 % of surviving patients, whereas, in 60 % non surviving patients the PCT level increased significantly (p < 0.001). A significant positive correlation between PCT and SOFA score was observed in survivors at each hour. These observations indicate that PCT concentration is significantly associated with severity of multi organ dysfunction and also helps in determining the prognosis of septic patients.     

High-gain fractional disturbance observer control of uncertain dynamical systems

Disturbance observer-based control allows to compensate unknown inputs, however, in most cases, requiring their integer-order differentiability. In this paper, a novel disturbance observer-based state feedback controller is proposed to compensate a more general class of fractional-, but not necessarily integer-order, differentiable unknown inputs. The proposed fractional PI-like structure yields precise conditions for feedback gain tuning. Remarkably, the resulting controller rejects non-differentiable disturbances with a smooth controller, guaranteeing robustness, an outstanding features for tracking tasks, under a prescribed practical stability regimen. A comparison to a fractional sliding mode observer is conducted via simulations to highlight the reliability of the proposed scheme.     

Between traditional classification and coordinate indexing

An ordering system for a global information network is necessary in order to enable the user to retrieve the particular information he is looking for. Classification has been one of the methods of ordering. The principle of traditional classification has been based on the idea of partitioning the universe of knowledge in mutually exclusive classes, i.e. subjects. A particular topic is defined by narrower classification within a class following the principle of ‘genusspecies’ relationship. Ranganathan's system of faceted classification has only replaced the classification of terms into subjects and sub-subjects by classification of terms into five ambiguous categories. Taube's system of coordinate indexing gives full freedom to the user to combine any number of terms of his choice. To be effective for social sciences such a system has to overcome some difficult problems of semantics. The system MANIS described here maintains the traditional classification and yet allows the user to combine terms of his choice, where the choice is restricted to the terms belonging to the system of traditional classification.     

A computer-based strategy for personalizing verbal problems in teaching mathematics

The purpose of this study was to evaluate a computer-based strategy for personalizing verbal problems used in mathematics instruction. Personalization was achieved through a computer program that incorporated names of familiar people and events, such as the student’s friends and birth date, into print copies of lesson examples. In two control treatments, concrete (nonadaptive) contexts and abstract contexts were employed. Subjects were 54 fifth- and sixthgraders studying a lesson on division of fractions. Results showed the personalized-context treatment to be advantageous relative to one or both control treatments for (a) solving conventional word problems, (b) solving transfer problems, (c) recognizing rule procedures, and (d) developing favorable attitudes toward materials. Theoretical interpretations of these effects are discussed, along with considerations about the practicality and effectiveness of the present application using print materials compared to an earlier one using CAl.     

“Our Leaders Are Us”: Youth Activism in Social Movements Project

In this article, we describe the development and implementation of a project, “Our Leaders Are Us: Youth Activism in Social Movements”, that we undertook with New York City high school students exploring events leading up to and following the Supreme Court’s landmark decision in Brown. As part of a 50th anniversary celebration of the Brown decision, we designed a series of three workshops that sought to extend urban students’ knowledge of Brown, segregation, and activism and to examine the roles of young people in critical civil rights campaigns. In addition, we discussed with students the ways in which young people can be involved in contemporary social movements and the strategies they can use to effect what they perceive to be needed changes in their lives. Along with the researchers’ extensive field notes, the participating students completed questionnaires throughout the project so that their understanding of Brown and related issues could be documented. Using our findings, we suggest ways that educators can develop and implement similar programs for use in schools.

Personalizing context in teaching mathematical concepts: Teacher-managed and computer-assisted models

The present paper examines a strategy intended to facilitate mathematics learning by adapting the context of instructional material to students’ backgrounds and interests. In four validation studies, the strategy was implemented through teacher management, using college students learning statistical probability rules as subjects. Achievement and attitude outcomes consistently favored treatment groups who received the adaptive contexts over control groups. The culmination of this research is the development of a computer-assisted model to increase the strategy’s practicality and sensitivity to learner differences. The computer model uses stored information about each student to personalize explanations and story examples on a fractions unit.     

A profile of health sciences libraries in Southeast Asia.

This paper reports the results of a survey undertaken by the World Health Organization of health sciences libraries in Southeast Asia. It includes information on clientele, budget, personnel, collections, lending policy, dissemination of information, and reference services. The survey indicates that the collections in most of the health sciences libraries in Southeast Asia are deficient and that services provided to readers are inadequate. Recommendations for improvement are outlined.     

Hypolipidemic effect of water extract ofFicus bengalensis in alloxan induced diabetes mellitus in rabbits

Hypolipidemic effect of the water extract of the bark ofFicus bengalensis was investigated in alloxan induced diabetes mellitus in rabbits. Treatment for one month (50 mg/kg body weight/day) brought down the level of total serum cholesterol (TC) in subdiabetic and diabetic rabbits (five in each group) from 82±11 mg% and 118±10.6 mg% to 42.7±3.1 mg% and 51.7±4.7 mg% respectively. Low density lipoprotein cholesterol and very low density lipoprotein cholesterol values came down from 34±10 mg% and 95±24 mg% to 16±3 mg% and 29±4 mg% in subdiabetic and diabetic rabbits. Triacylglycerol level before treatment was 121±21.6 mg% and 416±70 mg% in subdiabetic and diabetic rabbits. Treatment brought it down to 45±5 mg% and 81±27.5 mg%. Glycosylated hemoglobin was brought down from 2.1±0.3% to 1.5±0.1% in subdiabetic group and from 4.28±0.5% to 2±0.3% in diabetic group, indicating that treatment with water extract effectively controlled blood sugar. After treatment with water extract serum lipid values were nearly equal to those in healthy controls (normal) in subdiabetic rabbits, while in diabetic group, the values were only slightly above those of normal.     

Metabolic Syndrome in Childhood: Rare Case of Alstrom Syndrome with Blindness

Alstrom’s syndrome (AS) is a rare autosomal recessive ciliopathic condition affecting 1:10,00,000 children. It’s a single gene disorder of ALMS1 on chromosome 2 with multisystem involvement with cone-rod retinal dystrophy causing juvenile blindness, obesity, insulin resistance, type 2 Diabetes mellitus, hypogonadism and sensorineural hearing loss. Till now only 800 patients with this disorder has been identified so far. In this report, we describe the case of a 9-year old male boy from south India. He had been initially referred for polyphagia, polyuria, polydipsia, generalized weakness from 1 weeks. On examination he was demonstrated features suggestive of AS, including blindness, obesity, type 2 diabetes, altered lipid profile, hypogonadism, acanthosis nigricans, seborrheic dermatitis, right ear discharge and episodes of respiratory tract infections. So, diagnosis of AS is critical as it can easily be overlooked because of the many features associated with metabolic syndrome starting at age 7, a relatively early age.