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531.
532.
Pamela Green 《Journal of The Franklin Institute》2011,348(3):500-505
The discovery of small RNAs that can turn off genes has given us a new way to think about how genes are regulated. These molecules are present in all complex organisms and are thought to regulate upwards of 30% of human genes. Due to their small size, their discovery was surprisingly recent and was underappreciated initially. Beginning with two back-to-back papers published in 1993, the labs of Victor Ambros and Gary Ruvkun reported the first small RNA (now known as a microRNA or miRNA) and how it regulated a target mRNA in the roundworm Caenorhabditis elegans through base-pairing interactions. It took until 1999 for another report to document novel small RNAs in complex systems, when David Balcoumbe discovered similarly sized molecules, now known as small interfering RNAs or siRNAs, that were associated with shutting off or “silencing” genes in plants. A frenzy of reports on small RNAs and their roles in turning off genes ensued with many researchers including Ambros, Ruvkun, and Baulcombe prominently participating. Almost instantly it became clear that small RNAs were not a quaint oddity exclusive to the worm, and molecular biology was never the same. Now we know that these molecules are critical for normal growth and development, are associated with cancer and other diseases, and have tremendous applied potential to improve agriculture and human health. 相似文献
533.
Pamela J. Mulhall Dorothy V. Smith Christina E. Hart Richard F. Gunstone 《Research in Science Education》2017,47(5):1151-1168
We report on findings from a qualitative study of Australian scientists whose work brings them into contact with the public. This research sought to understand how a school science curriculum could better represent the work of scientists today. We discuss the views expressed by our participant scientists about the importance of openness and open-mindedness in their work, including their engagement with the public. They described openness as an important characteristic of science. Our participants also see open-mindedness on the part of both scientists and members of the public as important for productive relationships. They see the development of such relationships as an essential facet of their work. The views expressed by these scientists provide a provocative insight into the ways in which contemporary scientists see their work and relationships with their communities. Their perspectives have important implications for approaches to teaching science in schools. 相似文献
534.
Jeremy R. Grossman 《Quarterly Journal of Speech》2017,103(3):251-276
This essay reads former New Orleans mayor Ray Nagin’s infamous radio interview given during the aftermath of Hurricane to rethink both the popular narrative about the federal response to Katrina and, more broadly, the displacement of rhetorical objects both popularly and within rhetorical scholarship. Drawing upon Julia Kristeva’s early work, I advocate for a turn to a particular understanding of chōra, which positions critics in provisional relation objects of rhetorical study. Finally, I tender a reading of Nagin’s post-Katrina radio interview. The essay ultimately argues that: (1) the chōric function of Nagin’s interview simultaneously spurred political change and displaced the appearance of having done so; and (2) if rhetorical studies is to avoid remaining complicit with the politics of such displacement, scholars should attend carefully not only to what counts as rhetorical, but also to those objects that do not count but nevertheless function rhetorically. Reconsidering the object domain of rhetorical studies in this way not only opens up new objects for study but also accounts for how they might function outside of already established narratives. 相似文献
535.
This random assignment impact study of Big Brothers Big Sisters School-Based Mentoring involved 1,139 9- to 16-year-old students in 10 cities nationwide. Youth were randomly assigned to either a treatment group (receiving mentoring) or a control group (receiving no mentoring) and were followed for 1.5 school years. At the end of the first school year, relative to the control group, mentored youth performed better academically, had more positive perceptions of their own academic abilities, and were more likely to report having a "special adult" in their lives. However, they did not show improvements in classroom effort, global self-worth, relationships with parents, teachers or peers, or rates of problem behavior. Academic improvements were also not sustained into the second school year. 相似文献
536.
Pamela LePage Hanife Akar Yeliz TemliDerya ?en Neil Hasser Ilene Ivins 《Teaching and Teacher Education》2011,27(2):366-375
In this study, the researchers examined how K-8 teachers approach morality, moral education, and the moral development of children in Turkey and in the United States. Both countries have diverse cultures and long histories with secular education systems. Surveys were sent to teachers in nine cities in both countries. Results suggest that Turkish teachers emphasized societal values and global values, which have implications for the sustainability of the Turkish nation-state. American teachers emphasized moral action and morality in context (cultural relativity) rather than global values. Our findings emphasize the importance of inter-cultural awareness and tolerance. 相似文献
537.
Christine Pfund Kimberly C. Spencer Pamela Asquith Stephanie C. House Sarah Miller Christine A. Sorkness 《CBE life sciences education》2015,14(2)
Research mentor training (RMT), based on the published Entering Mentoring curricula series, has been shown to improve the knowledge and skills of research mentors across career stages, as self-reported by both the mentors engaged in training and their mentees. To promote widespread dissemination and empower others to implement this evidence-based training at their home institutions, we developed an extensive, interactive, multifaceted train-the-trainer workshop. The specific goals of these workshops are to 1) increase facilitator knowledge of an RMT curriculum, 2) increase facilitator confidence in implementing the curriculum, 3) provide a safe environment to practice facilitation of curricular activities, and 4) review implementation strategies and evaluation tools. Data indicate that our approach results in high satisfaction and significant confidence gains among attendees. Of the 195 diverse attendees trained in our workshops since Fall 2010, 44% report implementation at 39 different institutions, collectively training more than 500 mentors. Further, mentors who participated in the RMT sessions led by our trained facilitators report high facilitator effectiveness in guiding discussion. Implications and challenges to building the national capacity needed for improved research mentoring relationships are discussed. 相似文献
538.
Pamela W. Garner Marsha Carter McLean Badiyyah Waajid Evelyn R. Pittman 《Mentoring & Tutoring: Partnership in Learning》2013,21(4):293-310
The objective of this project was to develop and pilot a small-scale professional development program that incorporated substantial group and one-on-one mentoring aimed at preparing rurally based preschool teacher assistants to earn the Child Development Associate (CDA) credential. Using a framework that emphasized the relational, developmental, and contextual elements of mentoring, this qualitative case study examined both the participants’ and mentors’ perceptions of the program. Results of this study revealed overlapping themes across teacher assistants and their mentors, including readiness for the CDA credentialing process, mentoring support/relationship-building, and mutual respect. 相似文献
539.
Cheerleading, an American invention, has 3.8 million participants in the United States, 97% of whom are female. It is an adult‐sanctioned and typically school‐affiliated activity that remains popular in spite of the increase in sports' opportunities for girls in schools. Drawing from popular culture and a middle school ethnography, the authors document the enduring popularity of cheerleading and how it is a vehicle through which adolescent girls may try out various facets of what it means to be a contemporary American woman. The cheerleader represents both the ‘good’ girl as well as the sexy tease. Understanding the sexual tensions embedded in cheerleading in its nation of origin may provide educators in different national contexts ideas of how to use cheerleading as an educational tool. 相似文献
540.