Reliability of near-infrared spectroscopy for determining muscle oxygen saturation during exercise

Near-infrared spectroscopy is currently used to assess changes in the oxygen saturation of the muscle during exercise. The primary purpose of this study was to assess the reliability of near-infrared spectroscopy in determining muscle oxygen saturation (StO2) in the vastus lateralis during cycling and the gastrocnemius during running for exercise intensities at lactate threshold and maximal effort. Test-retest reliability was determined from an intraclass correlation coefficient obtained from a one-way analysis of variance. Reliability of muscle StO2 for the gastrocnemius at lactate threshold was R = .87, and R = .88 at maximal effort. Reliability of muscle StO2 for the vastus lateralis at lactate threshold was R = .94 and R = .99 at maximal effort.     

Development and evaluation of evidence-based nursing (EBN) filters and related databases.

OBJECTIVES: Difficulties encountered in the retrieval of evidence-based nursing (EBN) literature and recognition of terminology, research focus, and design differences between evidence-based medicine and nursing led to the realization that nursing needs its own filter strategies for evidence-based practice. This article describes the development and evaluation of filters that facilitate evidence-based nursing searches. METHODS: An inductive, multistep methodology was employed. A sleep search strategy was developed for uniform application to all filters for filter development and evaluation purposes. An EBN matrix was next developed as a framework to illustrate conceptually the placement of nursing-sensitive filters along two axes: horizontally, an adapted nursing process, and vertically, levels of evidence. Nursing diagnosis, patient outcomes, and primary data filters were developed recursively. Through an interface with the PubMed search engine, the EBN matrix filters were inserted into a database that executes filter searches, retrieves citations, and stores and updates retrieved citations sets hourly. For evaluation purposes, the filters were subjected to sensitivity and specificity analyses and retrieval set comparisons. Once the evaluation was complete, hyperlinks providing access to any one or a combination of completed filters to the EBN matrix were created. Subject searches on any topic may be applied to the filters, which interface with PubMed. RESULTS: Sensitivity and specificity for the combined nursing diagnosis and primary data filter were 64% and 99%, respectively; for the patient outcomes filter, the results were 75% and 71%, respectively. Comparisons were made between the EBN matrix filters (nursing diagnosis and primary data) and PubMed's Clinical Queries (diagnosis and sensitivity) filters. Additional comparisons examined publication types and indexing differences. Review articles accounted for the majority of the publication type differences, because "review" was accepted by the CQ but was "NOT'd" by the EBN filter. Indexing comparisons revealed that although the term "nursing diagnosis" is in Medical Subject Headings (MeSH), the nursing diagnoses themselves (e.g., sleep deprivation, disturbed sleep pattern) are not indexed as nursing diagnoses. As a result, abstracts deemed to be appropriate nursing diagnosis by the EBN filter were not accepted by the CQ diagnosis filter. CONCLUSIONS: The EBN filter capture of desired articles may be enhanced by further refinement to achieve a greater degree of filter sensitivity. Retrieval set comparisons revealed publication type differences and indexing issues. The EBN matrix filter "NOT'd" out "review," while the CQ filter did not. Indexing issues were identified that explained the retrieval of articles deemed appropriate by the EBN filter matrix but not included in the CQ retrieval. These results have MeSH definition and indexing implications as well as implications for clinical decision support in nursing practice.     

Chlordiazepoxide and the determinants of negative contrast

Previous experiments have shown that the negative contrast effect in consummatory behavior that occurs when rats are shifted from 32% to 4% sucrose is alleviated by the tranquilizer chlordiazepoxide (CDP). However, in these experiments, CDP was effective on the second postshift day but not on the first postshift day. The three experiments described in this paper suggest that this differential effectiveness of CDP is not due to the difference in preshift-postshift retention intervals on Day 1 (24 h) and Day 2 (48 h), but is due instead to the necessity of some degree of experience (about 5 min) with the postshift solution. These results, combined with those of an earlier study which showed elevated corticosterone in shifted animals on the second postshift day but not on the first postshift day, suggest that negative contrast may be a dynamic process, involving sequential processes of detection, evaluation, and conflict over the postshift period. It was further suggested that CDP becomes effective in moderating contrast only when the conflict stage is reached.     

Blaise CORTEX: A microprocessor system for libraries

In keeping with its role to provide information and cataloguing support services to the library and information world, the British Library is aware of the need to respond to its users' requirements by using the latest technology available. Since the development of intelligent terminals their application has been widespread in the community. The British Library has developed and adapted a commercially available intelligent terminal for specialist use within the library and information world, whilst at the same time retaining the terminal's own multi-faceted capabilities.     

Feeding the information eaters: Suggestions for integrating pure and applied research on language comprehension

This paper examines the current relation between pure and applied research on the comprehension of written information. It finds few points of contact. The suggestion is put forward that greater interaction could be mutually profitable. An information flow among researchers is proposed that starts with applied solutions to practical problems, continues through pure explanations of why these solutions are successful, and so enables the refinement of the original applied solutions. Because such an information flow begins with applied solutions, some of the problems of systematizing the findings of applied research are discussed. There can never be an applied theory of communication that specifies precisely how to design written information. Therefore a proposal is put forward for applying quality-control procedures to the preparation of documents. Such procedures indicate that several different kinds of research are necessary for determining the content, optimising the format and evaluating the effectiveness of written communications. The desirability of interactions among those who carry out these different kinds of research is discussed. Finally, the criteria for evaluating research in general are considered. The categorisation of particular studies as either useful or useless is found to be inappropriate.Thanks are due to Drs John Morton and John Marshall both for providing the incentive to put these thoughts in writing and for their advice and encouragement during the preparation of the paper. Many helpful comments on an earlier draft were received from Dr Arnold Wilkins, Dr James Hartley and Michael Macdonald-Ross. These were all much appreciated, even though some may appear not to have been implemented directly.