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991.
992.
Mala Mahto Baidarbhi Chakraborthy Srinivas H. Gowda Harneet Kaur Gaurav Vishnoi Pramod Lali 《Indian journal of clinical biochemistry : IJCB》2012,27(3):284-289
The implications of subclinical hypothyroidism (SCH) are many amongst which the most important is progression to overt hypothyroidism. Other debatable aspects are its association with cardiovascular risk, neuromuscular and psychiatric dysfunction, increased predisposition to developing metabolic syndrome and an underlying pro-inflammatory state. We aimed to study the lipid profile, lipoprotein(a) [Lp(a)] and hsCRP levels and insulin resistance in a group of patients with SCH in a referral hospital and see if any significant differences exist between them and euthyroids. This is a case–control study where the selection of controls and cases was based on the thyroid profile. Subjects were selected on their visit to clinical biochemistry lab for thyroid function tests. 33 euthyroids were taken as controls (Group I) and 38 patients comprising of subclinical hypothyroids were grouped as cases (Group II). Serum thyroid stimulating hormone (TSH) was in the range of 0.5–5.0 mIU/L for euthyroids and for subclinical hypothyroids the concentration of TSH was more than 5 mIU/L. The concentration of tri-iodothyronine (T3) and thyroxine (T4) were in normal reference range in both the groups. Individual lipid profile parameters failed to show a significant p value between cases and controls. The LDL/HDL ratio was highly significant (p value < 0.0001) and hsCRP was also statistically between the two groups (p value = 0.0054). Lp(a) and insulin resistance did not differ significantly. SCH is a common disorder that frequently progresses to overt hypothyroidism. This study underlines the importance of LDL/HDL ratio rather than measurement of individual lipid profile parameters in bringing to light the dyslipidemic state associated with SCH. Moreover the use of hsCRP to detect an underlying pro-inflammatory state in SCH can also be emphasized. 相似文献
993.
Burgess KB Wojslawowicz JC Rubin KH Rose-Krasnor L Booth-LaForce C 《Child development》2006,77(2):371-383
The primary objectives of this investigation were to examine the attributions, emotional reactions, and coping strategies of shy/withdrawn and aggressive girls and boys and to examine whether such social cognitions differ within the relationship context of friendship. Drawn from a sample of fifth and sixth graders (M age = 10.79 years; SD = .77), 78 shy/withdrawn, 76 aggressive, and 85 control children were presented with hypothetical social situations that first involved unfamiliar peers, and then a mutual good friend. Results revealed group and gender differences and similarities, depending on the relationship context. From our findings emerges a central message: friends' involvement during interpersonal challenges or stressors mitigates children's attributions, emotions, and coping responses. 相似文献
994.
Previous studies have reported, but not explained, the reason for a robust association between reading achievement and antisocial behavior. This association was investigated using the Environmental Risk (E-Risk) Longitudinal Twin Study, a nationally representative 1994-1995 birth cohort of 5- and 7-year-olds. Results showed that the association resulted primarily from environmental factors common to both reading and antisocial behavior and was stronger in boys. Environmental factors also explained the relation between reading disability and conduct disorder. Leading candidate environmental risk factors weakly mediated the association. For boys the best explanation was a reciprocal causation model: poor reading led to antisocial behavior, and vice versa. In contrast, the relation between reading achievement and attention deficit hyperactivity disorder was best explained by common genetic influences. 相似文献
995.
996.
Habib M Hussain I Fang WH Rajput ZI Yang ZZ Irshad H 《Journal of Zhejiang University. Science. B》2006,7(4):320-323
In this experiment conducted to study the inactivation dynamics of infectious bursal disease virus (IBDV) by binary ethylenimine (BEI) in comparison with formalin, IBDV was isolated from the bursa of infected chickens and its confirmation was done by agar gel precipitation test. Viral suspensions were subjected to inactivation with BEI and formalin for pre-set time in- tervals. BEI was employed at concentrations of 0.001 and 0.002 mol/L while formalin was used at 0.1% and 0.2%. Sampling was done at 6, 12, 24, 36 and 48 h of incubation and samples were tested for their inactivation status in 9-day-old embryonated eggs and 3-week-old broiler chickens. IBDV was completely inactivated by 0.001 and 0.002 mol/L BEI after 36 h of incubation at 37℃, whereas formalin at 0. 1% and 0.2% concentrations inactivated IBDV in 24 h. 相似文献
997.
How golden is silence? Teaching undergraduates the power and limits of RNA interference 总被引:1,自引:1,他引:0
Kuldell NH 《CBE life sciences education》2006,5(3):247-254
It is hard and getting harder to strike a satisfying balance in teaching. Time dedicated to student-generated models or ideas is often sacrificed in an effort to “get through the syllabus.” I describe a series of RNA interference (RNAi) experiments for undergraduate students that simultaneously explores fundamental concepts in gene regulation, develops cutting-edge laboratory skills, and embraces student-directed learning. Students design a small interfering RNA (siRNA) against luciferase, add it to cells expressing this gene, and then quantitatively assess the siRNA's effect on both intended and unintended targets, using a luciferase assay and a DNA microarray. Because both RNAi and microarray technologies are relatively new, with no clear consensus on their analysis or limitations, students are encouraged to explore different approaches to the design of their reagents and interpretations of their data. The ability to creatively formulate a hypothesis-driven experimental approach to a scientific question and to critically evaluate collected data is stressed. Equally important, this experiment emphasizes how modern scientific ideas emerge, are debated, tested, and decided. 相似文献
998.
We explore the feasibility of automatically identifying sentences in different MEDLINE abstracts that are related in meaning.
We compared traditional vector space models with machine learning methods for detecting relatedness, and found that machine
learning was superior. The Huber method, a variant of Support Vector Machines which minimizes the modified Huber loss function,
achieves 73% precision when the score cutoff is set high enough to identify about one related sentence per abstract on average.
We illustrate how an abstract viewed in PubMed might be modified to present the related sentences found in other abstracts
by this automatic procedure. 相似文献
999.
本文用201种禾本科植物幼苗的60个形态和解剖性状进行了聚类分析,将禾本科植物分为四个大类(一级聚合单位)—狐茅类(Festucoid)、黍类(Panicoid),竹类(Bambusoid)和画眉草类(Eragrostidoid)。这四类基本上与分类系统中的亚科相吻合,只是芦竹亚科植物的幼苗分散聚到了其它类中。推测芦竹亚科是一个比较原始的类群,狐茅亚科、黍亚科和画眉草亚科可能是在芦竹亚科的基础上进化而来的。 除个别种外,大多数同属的种在较低的聚合水平上聚在一起,超族在亚聚合单位中基本上能够反映出来。 研究证明禾本科植物的幼苗性状在禾本科植物分类中具有重要的分类学意义。 相似文献
1000.
体育活动与老年人的抑郁:系统综述 总被引:3,自引:1,他引:3
孙延林 《天津体育学院学报》2002,17(2):49-54
抑郁是老年人一种常见的不良情绪,通过对描述性研究,元分析研究,流行病学研究和实验研究的综述,认为体育活动对减轻老年人的抑郁有积极作用。 相似文献