Injectable hybrid inorganic nanoscaffold as rapid stem cell assembly template for cartilage repair

Cartilage injuries are often devastating and most cannot be cured because of the intrinsically low regenerative capacity of cartilage tissues. Although stem-cell therapy has shown enormous potential for cartilage repair, the therapeutic outcome has been restricted by low survival rates and poor chondrocyte differentiation in vivo. Here, we report an injectable hybrid inorganic (IHI) nanoscaffold that facilitates fast assembly, enhances survival and regulates chondrogenic differentiation of stem cells. IHI nanoscaffolds that strongly bind to extracellular matrix (ECM) proteins assemble stem cells through synergistic 3D cell–cell and cell–matrix interactions, creating a favorable physical microenvironment for stem-cell survival and differentiation in vitro and in vivo. Additionally, chondrogenic factors can be loaded into nanoscaffolds with a high capacity, which allows deep, homogenous drug delivery into assembled 3D stem-cell-derived tissues for effective control over the soluble microenvironment of stem cells. The developed IHI nanoscaffolds that assemble with stem cells are injectable. They also scavenge reactive oxygen species and timely biodegrade for proper integration into injured cartilage tissues. Implantation of stem-cell-assembled IHI nanoscaffolds into injured cartilage results in accelerated tissue regeneration and functional recovery. By establishing our IHI nanoscaffold-templated 3D stem-cell assembly method, we provide a promising approach to better overcoming the inhibitory microenvironment associated with cartilage injuries and to advance current stem-cell-based tissue engineering.     

大学生择业受挫心理的表现及对策分析

大学生择业的表现通常有:焦虑、悲观失望、嫉妒等,这些表现的原因主要有:大学生的择业观不正确,大学生对用人单位的了解不足,缺乏社会实践经验,用人单位、学校及家庭的负面影响。大学生树立正确的择业观,充分了解求职单位,积极参加实践活动,减小用人单位、学校及家庭的负面影响是减少大学生择业受挫的有力措施。     

从"传者-受者"到"对话者"——Web2.0时代组织外部传播的传受关系分析

在"全民织网"的Web2..时代,无数普通人成为信息的主动生产者、发布者、传递者和组织者,并以新方式实现"人与人"之间的连接.在这种全新的传播生态中,组织与外部环境(尤其是普通社会公众)是依据怎样的关系进行信息交互和传播活动的呢?与传统大众媒介时代的"传者一受者"关系相比,组织与普通社会公众的传播关系是否出现了新变化?通过分析本文认为,在Web2.0时代,由于普通社会公众在传播过程中地位和力量的上升,在组织面对社会公众进行外部传播活动的过程中,双方的关系正逐渐演变为更为平等的、双向互动的、充满人情味的"对话者"关系.     

馆校协同教学:馆校合作教学模式的理论探索

当前场馆与学校的联系还停留在偶然性的场馆参观和随意性的校内展览,亟待寻得一种科学、便捷、可行的馆校合作模式.馆校协同教学是以"一般学习结果理论"的五维价值为核心的,场馆资源系统与学校教学系统可协同运作的合作模式和理论体系,其包括知识与理解,技能,态度与价值观,娱乐性、启发性和创新性,活动、行为和成长五方面内容.同时,馆校协同教学还表现出目的性、开放性和民主性三方面的教育规定性.活动范式上,它又包括物理参与、情感参与、智识参与和社交参与四种类型.     

传统运动养生文化对城镇社区体育锻炼的影响

在中国几千年的历史发展中,运动养生文化能滋生繁衍、常青不衰,有其自身的存在价值.着重探讨中国传统运动养生文化对现代社会社区体育锻炼的影响,是为了更好地继承与弘扬中国传统运动文化,继而为社区居民体质的提高和体育锻炼发展,提供宝贵的运动养生资源.讨论在城镇化进程加快的过程中,社区居民单一的生活和休闲方式,还有社区体育锻炼缺乏等方面,运用运动养生进行体育锻炼能有效增强社区居民的体质健康和丰富居民的生活方式.     

浅谈我国竞技体育的发展与变化

中国体育在世界格局中明确了第一集团的位置,但是优势项目不多,并且很难获得更大突破,在国内优势项目与区域发展也存在不均衡的表现。探讨了近些年中国体育在世界取得的成绩情况,分析了实力变化情况,以期促进我国竞技体育的可持续发展。     

Automatic measurement of key ski jumping phases and temporal events with a wearable system

We propose a new method, based on inertial sensors, to automatically measure at high frequency the durations of the main phases of ski jumping (i.e. take-off release, take-off, and early flight). The kinematics of the ski jumping movement were recorded by four inertial sensors, attached to the thigh and shank of junior athletes, for 40 jumps performed during indoor conditions and 36 jumps in field conditions. An algorithm was designed to detect temporal events from the recorded signals and to estimate the duration of each phase. These durations were evaluated against a reference camera-based motion capture system and by trainers conducting video observations. The precision for the take-off release and take-off durations (indoor < 39 ms, outdoor = 27 ms) can be considered technically valid for performance assessment. The errors for early flight duration (indoor = 22 ms, outdoor = 119 ms) were comparable to the trainers' variability and should be interpreted with caution. No significant changes in the error were noted between indoor and outdoor conditions, and individual jumping technique did not influence the error of take-off release and take-off. Therefore, the proposed system can provide valuable information for performance evaluation of ski jumpers during training sessions.     

法新社：NewsML 标准的同路人

参加IPTC北京年会的法新社多媒体实验室主任、资深媒体技术、新闻技术标准专家Laurent Le Meur先生4月3日在新华社的技术研讨会上,首先介绍了法新社的新闻业务和技术概况,他说：法新社每天播发及时、精确、深度报道,每天有遍及世界165个国家的2900名员工为其工作,每天播发视频、图片、图表和多媒体稿件,法新社每天发布的多媒体稿件达350～600篇左右,每天播发的各类新闻大多遵循了NewsML标准。