A case of vitamin B12 deficiency neurological syndrome in a young adult due to late-onset cobalamin C (CblC) deficiency: a diagnostic challenge

Vitamin B12 deficiency can present with neurologic and psychiatric symptoms without macrocytic anaemia. We describe a case of late-onset cobalamin C deficiency which typically presents with normal serum vitamin B12 concentrations, posing an additional diagnostic challenge. A 23-year-old woman with decreased muscle strength and hallucinations was diagnosed with ‘catatonic depression’ and admitted to a residential mental health facility. She was referred to our hospital for further investigation 3 months later. Heteroanamnesis revealed that the symptoms had been evolving progressively over several months. Magnetic resonance imaging (MRI) of the brain showed diffuse symmetrical white matter lesions in both hemispheres. Routine laboratory tests including vitamin B12 and folic acid were normal except for a slight normocytic, normochromic anaemia. Over the next 6 weeks her symptoms deteriorated, and she became unresponsive to stimuli. A new MRI scan showed progression of the white matter lesions. The neurologist requested plasma homocysteine (Hcys) which was more than 8 times the upper limit of normal. Further testing revealed increased methylmalonic acid and the patient was diagnosed with adult-onset cobalamin C deficiency. This case illustrates that Hcys and/or methylmalonic acid should be determined in patients presenting with neuropsychiatric symptoms suggestive of vitamin B12 deficiency with a normal serum vitamin B12 to rule out a late-onset cobalamin C deficiency.     

Intrachild variabilities: Will curtailment of testing harm minority children?

Compared intrachild variability of five-year-old children (49 black, 34 white) on the Primary Mental Abilities Test when subjects reached their fifth birthday after completing at least two years of preschool enrichment. Conclusions, although qualified on the basis of limited sample size, revealed wider intrachild variability with minority children. This suggests that abandonment of testing may increase instructional problems and possibly lower the quality of instruction provided minority and poor children.     

排名的困境

分析了大学排行榜产生的原因,指出了大学排名活动中存在的问题,如评估指标的选取、大学的不同定位等,进而指出世界范围内的排名活动会加大英语国家大学的强势,不利于发展中国家大学的发展,并认为大学排名活动应以准确的评估和科学的指标体系作为基础。     

网球比赛分析的几个关键点

许多运动队将全程比赛分析作为教练员的指导工具,研究己方和对方运动员的类型、战术和技术特点.网球项目中,拥有个人分析师的运动员并不多见,大部分运动员和教练员使用分析设备和程序提供的客观、可靠的反馈信息,自己进行赛前及赛后分析.很多教练员采用其他教练员的有效训练模式,因为不是所有人都有时间去分析1000h的大满贯录像来找出战术差异,但可利用他人的分析结果.赛事录像记录的客观数据提供了充足的反馈信息,教练员可根据这些反馈信息调整技战术,进行针对性的训练.     

Coordination variability and skill development in expert triple jumpers

The aim of this study was to examine the influence of skill of expert triple jumpers on the coordination variability of lower extremity intra-limb couplings. In contrast to the traditional motor learning perspective, we hypothesized that as skill and thus performance increases, movement coordination variability will also increase. Three-dimensional kinematic and ground reaction force data were collected during the hop-step transition phase of the triple jump. Relative motion plots and a modified vector coding technique were used to quantify the coordination variability across the trials. The results were consistent with a U-shaped curve, representing coordination variability, as skill increases. The high coordination variability in less skilled athletes is present while the appropriate characteristics defining the movement coordination patterns are acquired. This coordination variability may not be beneficial to performance. As the refinement of these characteristics is achieved, coordination variability decreases, resulting in a more consistent or regulated performance. In the final stages of developing a skilled performance, a functional variability is accessed that brings flexibility to the system allowing it to cope with perturbations. This study highlights the need to address the learning effect when analysing coordination variability from a dynamical systems perspective.     

Validation of self-report measures of physical activity: a case study using the New Zealand Physical Activity Questionnaire

Accurate measurement of physical activity is fundamentally important in epidemiological research of physical activity behavior A widely used telephone-based physical activity questionnaire was compared with other methods of administration and objective measures (pedometers and accelerometers) among 80 adults (43 women). The telephone questionnaire was comparable to both the self-administered form and international telephone-administered equivalent. Although moderate correlation coefficients with objective measures supported the use of the questionnaire, wide prediction intervals generated using Bland Altman methods highlighted large discrepancies between the measures, particularly in the moderate intensity category. These findings illustrate the limitations of correlation coefficients in validation studies and the inaccuracy of self-report questionnaires in measuring physical activity.     

Repeated retention testing effects do not generalize to a contextual interference protocol

Three experiments examined repeated retention testing effects in a contextual interference (CI) protocol. Retention was assessed at 10 min and 24 hr following acquisition or at just 24-hr for the one-test conditions. Experiments 1 and 2 used speeded-response key-pressing tasks. Dependent measures were total time and errors. Experiment 3 used sequential-timing tasks. Dependent measures were absolute error and absolute constant error Results revealed CI effects in each experiment. Repeated retention testing effects were not found in Experiments 1 and 3. Experiment 2 revealed superior performance by the two-test condition compared to the one-test condition. This result was qualified by possible practice effects during the 10-min test. It was concluded that repeated retention testing does not present problems for most studies of CI.     

The role of upper torso and pelvis rotation in driving performance during the golf swing

While the role of the upper torso and pelvis in driving performance is anecdotally appreciated by golf instructors, their actual biomechanical role is unclear. The aims of this study were to describe upper torso and pelvis rotation and velocity during the golf swing and determine their role in ball velocity. One hundred recreational golfers underwent a biomechanical golf swing analysis using their own driver. Upper torso and pelvic rotation and velocity, and torso-pelvic separation and velocity, were measured for each swing. Ball velocity was assessed with a golf launch monitor. Group differences (groups based on ball velocity) and moderate relationships (r > or = 0.50; P < 0.001) were observed between an increase in ball velocity and the following variables: increased torso-pelvic separation at the top of the swing, maximum torso-pelvic separation, maximum upper torso rotation velocity, upper torso rotational velocity at lead arm parallel and last 40 ms before impact, maximum torso-pelvic separation velocity and torso-pelvic separation velocity at both lead arm parallel and at the last 40 ms before impact. Torso-pelvic separation contributes to greater upper torso rotation velocity and torso-pelvic separation velocity during the downswing, ultimately contributing to greater ball velocity. Golf instructors can consider increasing ball velocity by maximizing separation between the upper torso and pelvis at the top of and initiation of the downswing.     

Differential contribution of personality to the explanation of variance in achievement in the first language and mathematics at high school level

This study assessed the differential contribution of personality to the explanation of variance in achievement in the mother tongue and mathematics at the high school level. The results indicated that personality, as measured by the HSPQ, aided the explication of variance in achievement in the mother tongue significantly, but had little influence on mathematics. Personality contributed as much to the explanation of variance in the mother tongue as did the composite cognitive variable. The influence of personality on achievement in mathematics was shown to be negligible. Some practical implications for the teaching of the first language are drawn.