Glycated nail proteins as a new biomarker in management of the South Kivu Congolese diabetics

Introduction

Diagnosis and monitoring of diabetes mellitus in sub-Saharan Africa, based on blood analyses, are hampered by infrastructural and cultural reasons. The first aim of this study was to evaluate the diagnostic accuracy of glycated nail proteins for diabetes mellitus. The second aim was to compare the course of short- and long-term glycemic biomarkers after 6 months of antidiabetic treatment. These objectives should support our hypothesis that glycated nail proteins could be used as an alternative glycemic biomarker.

Materials and methods

This case-control study consisted of 163 black diabetics and 67 non-diabetics of the South Kivu (Democratic Republic of Congo). Diagnostic accuracy of glycated nail proteins was evaluated using ROC curve analysis. At the start of the study, glycated nail protein concentrations were compared between diabetics and non-diabetics, using a nitro blue tetrazolium (NBT) colorimetric method. In a subgroup of 30 diabetics, concentrations of glycated nail proteins, fasting glucose (Accu-Chek® Aviva), serum fructosamine (NBT) and HbA1c (DCA-2000+®) were measured at start and after 6 months.

Results

ROC analysis yielded an AUC of 0.71 (95% confidence interval (CI): 0.65-0.76) and a cut-off point of 3.83 μmol/g nail. Concentration of glycated nail proteins was significantly higher (P < 0.001) in diabetics in comparison with non-diabetics. After 6 months of antidiabetic treatment, a significant drop in the fasting glucose concentration (P = 0.017) and concentration of glycated nail proteins (P = 0.008) was observed in contrast to serum fructosamine and HbA1c.

Conclusions

Measurement of glycated nail proteins could be used to diagnose and monitor diabetes mellitus in sub-Saharan Africa.Key words: fasting glucose concentration, fructosamine, hemoglobin A1c protein, nails, sub-Saharan Africa, diabetes mellitus     

‘White men can’t jump in a black basketball game?’ An exploratory investigation of implicit strategies of outgroup discrimination

Examining the ‘natural’ athlete myth and utilizing the recent literature on cultural/social factors in athleticism and basketball, this study through survey research examines the influence of stereotypes on the impression formation of basketball players. The primary research question is to determine from a group of students the attitudes of basketball players in terms of how they evaluate white and black players in basketball. The purpose is to identify participants’ perceptions and their appreciation as to whether or not black are superior to white basketball players. The theoretical framework employed is articulated around the theory of social categorization and racial stereotypes already observed in sports. In an initial qualitative phase, the results show that stereotypical representations exert an influence on the skills associated with basketball players depending on the colour of their skin, which is reflected in the use of adjectives specific to each of the categories of black and white. In a second quantitative phase, whereas a more favourable view of black basketball players might have been attributable to positive discrimination as per the anti-racist norm, the results show the activation of a bias towards favouring one’s own group. Once all of the initial adjectives have been expressed, the targets behave in the expected way in terms of the laws of social categorization i.e. they have a more positive view of the members of their own group (the Whites) than of the other group (the Blacks) as adjectives are cited for describing skills.     

Anthropogenic emission is the main contributor to the rise of atmospheric methane during 1993–2017

Atmospheric methane (CH₄) concentrations have shown a puzzling resumption in growth since 2007 following a period of stabilization from 2000 to 2006. Multiple hypotheses have been proposed to explain the temporal variations in CH₄ growth, and attribute the rise of atmospheric CH₄ either to increases in emissions from fossil fuel activities, agriculture and natural wetlands, or to a decrease in the atmospheric chemical sink. Here, we use a comprehensive ensemble of CH₄ source estimates and isotopic δ¹³C-CH₄ source signature data to show that the resumption of CH₄ growth is most likely due to increased anthropogenic emissions. Our emission scenarios that have the fewest biases with respect to isotopic composition suggest that the agriculture, landfill and waste sectors were responsible for 53 ± 13% of the renewed growth over the period 2007–2017 compared to 2000–2006; industrial fossil fuel sources explained an additional 34 ± 24%, and wetland sources contributed the least at 13 ± 9%. The hypothesis that a large increase in emissions from natural wetlands drove the decrease in atmospheric δ¹³C-CH₄ values cannot be reconciled with current process-based wetland CH₄ models. This finding suggests the need for increased wetland measurements to better understand the contemporary and future role of wetlands in the rise of atmospheric methane and climate feedback. Our findings highlight the predominant role of anthropogenic activities in driving the growth of atmospheric CH₄ concentrations.     

Science, technology and innovation for economic growth: Linking policy research and practice in ‘STIG Systems’

This paper reflects on the relevance of “systems-theoretic” approaches to the interdependent policy issues relating to the dynamics of science, technology and innovation and their relationship to economic growth. Considering the approach that characterizes much of the current economics literature's treatment of technology and growth policies, we pose the critical question: what kind of systems paradigm is likely to prove particularly fruitful in that particular problem-domain? Evolutionary, neo-Schumpeterian, and complex system dynamics approaches are conceptually attractive, and we examine their respective virtues and limitations. Both qualities are readily visible when one tries to connect systems-relevant research with practical policy-making in this field.     

Greater fatigability in knee-flexors vs. knee-extensors after a standardized fatiguing protocol

The present study aimed to investigate the effects of a standardized fatiguing protocol on central and peripheral fatigue in knee-flexors and knee-extensors. Thirteen healthy men (age: 23?±?3 years; height: 1.78?±?0.09 m; body-mass: 73.6?±?9.2?kg) volunteered for the present study. Maximal voluntary contraction (MVC), Electromyography (EMG) activity, voluntary activation level (VAL) as an index of central fatigue and twitch potentiation as an index of peripheral fatigue were measured before and after the fatiguing protocol. The fatiguing protocol consisted of a 0.6 duty-cycle to exhaustion (6?s isometric contraction, 4?s recovery) at 70% MVC. After the fatiguing protocol, MVC decreased in both (Effect-size (ES)?=?1.14) and knee-extensors (ES?=?1.14), and EMG activity increased in both knee-flexors (ES?=?2.33) and knee-extensors (ES?=?1.54). Decreases in VAL occurred in knee-flexors (ES?=?0.92) but not in knee-extensors (ES?=?0.04). Decreases in potentiation occurred in both knee-flexors (ES?=?0.84) and knee-extensors (ES?=?0.58). The greater central occurrence of fatigue in knee-flexors than in knee-extensors may depend on the different muscle morphology and coupled with a greater tolerance to fatigue in knee-extensors. The present data add further insight to the complicated knee-flexors-to-knee-extensors strength relationship and the mechanisms behind the different occurrence of fatigue.     

Linking intellectual capital and knowledge management: an analysis of Kyoto and Detroit

The successes and failures of Detroit and Kyoto, from intellectual capital and organizational knowledge perspectives, are compared in terms of their similarities and differences as they both strive to maintain an accepted level of social development, global adjustment and urban quality of life. This paper examines the state of development of the four domains of knowledge in Detroit and Kyoto from a historical perspective, applies that analysis to the current state of knowledge and identifies linkages between intellectual capital and knowledge development.     

Impact of hockey skate design on ankle motion and force production

Dynamic forces and range of motion (ROM) were measured during on-ice skating using a standard hockey skate and a modified skate (MS) with an altered tendon guard and eyelet configuration. The objective of this study was to determine if these modifications resulted in biomechanical and performance changes during on-ice skating skills. The right skate of each type was instrumented with a calibrated strain gauge force transducer system to measure medial?Clateral and vertical forces during ice skating. In addition, a goniometer was placed about the ankle and rear foot to measure ROM during skating. Ten subjects executed three skills: forward skating, crossovers inside foot and crossovers outside foot. The MS demonstrated significant gains of 5°?C9° in dorsi-plantarflexion ROM (p?<?0.05). Total peak force occurred later during plantarflexion, suggesting a more prolonged and effective force generation with the MS during a given skating stride. A 14?C20?% increase (p?>?0.05) in mean work and power output was noted with the MS, although no improved times were observed during the skating skills. Potentially, some players may need a period of familiarization to take advantage of the design alterations of the MS.     

From Mitropa Cup to UEFA Cup: the role of UEFA in the establishment of a European scale in football, 1927–1972

ABSTRACT

Since the 1920s, many European exchanges began to exist in the domain of football. However, it was during the 1950s that a European scale was established primarily due to the creation of UEFA (Union of European Football Associations) in 1954, which quickly organized the first European tournament in the game’s history– The European Champions Clubs’ Cup. The present essay argues that Europeanization of the game has to be understood in a long-term perspective. The papers examines the creation and development of three competitions as key defining events, which represented different stages of the Europeanization of the game: Mitropa Cup (created in 1927), European Champion Clubs’ Cup (created in 1955) and UEFA Cup (created in 1971). Thus, afocus on these cases can help us better understand the background of the Europeanization of the game which happened during the 1990s.     

Ice hockey skating sprints: run to glide mechanics of high calibre male and female athletes

ABSTRACT

The skating acceleration to maximal speed transition (sprint) is an essential skill that involves substantial lower body strength and effective propulsion technique. Coaches and athletes strive to understand this optimal combination to improve performance and reduce injury risk. Hence, the purpose of this study was to compare body centre of mass and lower body kinematic profiles from static start to maximal speed of high calibre male and female ice hockey players on the ice surface. Overall, male and female skaters showed similar centre of mass trajectories, though magnitudes differed. The key performance difference was the male’s greater peak forward skating speed (8.96 ± 0.44 m/s vs the females’ 8.02 ± 0.36 m/s, p < 0.001), which was strongly correlated to peak leg strength (R ² = 0.81). Males generated greater forward acceleration during the initial accelerative steps, but thereafter, both sexes had similar stride-by-stride accelerations up to maximal speed. In terms of technique, males demonstrated greater hip abduction (p = 0.006) and knee flexion (p = 0.026) from ice contact to push off throughout the trials. For coaches and athletes, these findings underscore the importance of leg strength and widely planted running steps during the initial skating technique to achieve maximal skating speed over a 30 m distance.     

Assessment of the risk and biomechanical consequences of lateral epicondylalgia by estimating wrist and finger muscle capacities in tennis players

Previous studies suggested that a pronounced weakness of the extensor muscles relative to the flexor muscles could increase the risk of occurrence of lateral epicondylalgia. This study investigates this hypothesis by estimating the ratio of extensor to flexor muscle capacities among healthy non-players (n = 10), healthy tennis players (n = 20), symptomatic players (n = 6), and players who have recovered from lateral epicondylalgia (n = 6). Maximum net joint moments in flexion or extension were measured during seven tasks involving the voluntary contraction of wrist and fingers. Using these data, the muscle capacities of the main muscle groups of the hand (wrist flexors, wrist extensors, finger flexors, finger extensors, and intrinsic muscles) were estimated using a musculoskeletal model. These capacities were then used to compute the extensor/flexor capacity ratios about the wrist and the finger joints. Compared to healthy non-players, healthy players presented higher extensor muscle capacities and greater capacity ratios showing that playing tennis generates specific adaptations of muscle capacities. Interestingly, symptomatic players, similar to those of non-players, showed more imbalanced ratios than healthy players. These results confirm that the ratio of extensor/flexor muscle capacities seems to be associated with lateral epicondylalgia and can be further used to understand its incidence and consequences.