Transportation of AIE-visualized nanoliposomes is dominated by the protein corona

Liposomes, especially cationic liposomes, are the most common and well-investigated nanocarriers for biomedical applications, such as drug and gene delivery. Like other types of nanomaterials, once liposomes are incubated in a biological milieu, their surface can be immediately cloaked by biological components to form a protein corona, which confers a new ‘biological identity’ and modulates downstream interactions with cells. However, it remains unclear how the protein corona affects the transportation mechanism after liposomes interact with cells. Here, we employed home-made aggregation-induced-emission-visualized nanoliposomes TR4@Lipo as a model to investigate transportation with or without the protein corona by optical imaging techniques. The results show that the protein corona can change the cellular transportation mechanism of TR4@Lipo from energy-independent membrane fusion to energy-dependent endocytosis. The protein corona also modulates the intracellular distribution of loaded cargoes. This knowledge furthers our understanding of bio-nano interactions and is important for the efficient use of cationic liposomes.     

Examining the Beliefs and Practices of Four Effective Australian Primary Science Teachers

With trends across many countries still indicating the decline of student interest in school science and diminishing numbers of students studying science beyond the compulsory years, it seems that the field remains in crisis. To address these unfortunate trends, there needs to be a greater emphasis on science education research that highlights the good news stories. For example, what are science teachers actually doing in their classrooms to increase student interest and understanding in science? This article focuses on the science teaching beliefs and practices of four Western Australian primary school teachers. The teachers were nominated by a professional colleague as effective practitioners. The study involved gathering information from classroom observations and teacher interviews to provide background information to assist in developing understandings of these teachers and their science teaching. This article reports on the initial findings drawn from Deanne A, Kate B, Lisa C and Rebecca D. Their practices were organised into the following six categories: classroom environment; conceptual knowledge and procedural skills; teaching strategies and approaches; student-specific considerations; teacher-specific considerations; and context-specific considerations. In examining the components contributing to these categories, it was evident that the teachers’ beliefs, as well as the contextual factors inherent in each classroom environment, influenced how and why they teach science in the ways they do.     

Twelve Ways to Incorporate Strengths-Based Planning into the IEP Process

The Individuals with Disabilities Education Improvement Act 2004 (IDEA) requires public schools to assure that parents of students with disabilities have the opportunity to participate in Individualized Education Program (IEP) meetings. Strengths-based IEPs focus on student strengths and abilities, rather than weaknesses and disabilities, in preparing parents and teachers for the IEP meeting, presenting information at the meeting, and documenting the meeting in writing. As a special education administrator for more than 27 years, the author has experience in working with parents from the strengths-based perspective, including encouraging parents to participate in the IEP process. In 1994 the author, along with parents of students with disabilities, developed a checklist for parents and public school teachers that focused on the strengths-based approach and was intended to encourage parents to participate actively in IEP meetings. Twelve techniques for reducing conflict and encouraging parents to participate in the IEP planning process at the middle and high school level are presented and described.     

DEVELOPING AND EVALUATING AN INTERDISCIPLINARY CLINICAL TEAM TRAINING PROGRAM: LESSONS TAUGHT AND LESSONS LEARNED

The training of clinicians in working together as an interdisciplinary team has received growing support in geriatrics. Most teamwork training programs have focused on group process and development as the core competencies of team practice necessary to improve levels of team functioning. The experience of the Rhode Island Geriatric Education Center (RIGEC) in developing and implementing an ongoing teamwork training program, including the training of several geriatric teams from a variety of health care settings, suggests that additional objectives should include the empowerment of teams for advocacy in rapidly changing health care settings increasingly shaped by economic forces. The lessons learned by RIGEC for the development and implementation of teamwork training include the importance of defining team membership, dealing with the shifting shoals of the health care system, understanding individuals and systems under stress, and redefining the objectives of teamwork training.     

Capacity building of a district education system: insights from Kenya

Both (a) in-school factors such as over-focus on academic performance, absence of uniform, and corporal punishment, and (b) out-of school factors such as caring for ailing parents, child labour, etc., hinder participation of orphan and vulnerable children (OVC) in Free Primary Education (FPE) system in Nyanza Province, Kenya. In this context Concern Worldwide Kenya undertook an appreciative capacity building approach and appropriately positioned District Education Office (DEO) of the Ministry of Education and local civil society organisations (CSOs) to address in-school and out-of-school factors, respectively, to ensure quality education for OVC. The outcome of the programme is promising and has demonstrated the need for greater cooperation between CSOs and the government to develop creative strategies in overcoming the causes of marginalisation within the contexts of the growing AIDS pandemic and poverty in Kenya.     

Re-reading the reading lesson: episodes in the history of reading pedagogy

Reading pedagogy is constantly an object of discussion and debate in contemporary policy and practice but is rarely a matter for historical inquiry. This paper reports from a recent study of the history of reading pedagogy in Australia and beyond. It focuses on a recurring figure in the historical record—the ‘reading lesson’. Presented as a distinctive trope, the reading lesson is traced in its regularity in and through the discourse of reading pedagogy, starting in 1930s Australia and moving back into 19th-century Europe, and with specific reference to the UK and the USA. Teaching reading is expressly identified as a moral project—something that, it can be argued, clearly continues into the present.     

Endorsed and Applied Rules of Relationships Reported by Teachers

Recent academic debates on the geography curriculum for schools have highlighted the need for more focus on how knowledge is socially produced. While this may help to bridge the gap between the school curriculum and epistemological developments in academia, it is unclear how such theoretical frameworks can improve pupils' learning about the world. In this paper theoretical approaches to knowledge are challenged by considering, from an alternative viewpoint, how pupils themselves act as knowledge producers. Drawing on the holistic educational philosophy informing the Steiner-Waldorf approach to curriculum knowledge and pedagogy, it is argued that subject knowledge needs to suit the way pupils' thinking naturally evolves, giving particular attention to the role that imagination and sense of wonder play in both the cognitive process and pupil engagement. The epistemological status of the pupil in geography education can therefore be enhanced by considering approaches to education that operate outside normal scientific and rational paradigms. This has relevance for the wider debate on more flexible, post-industrial forms of learning.     

A national systems view of university entrepreneurialism: Inferences from comparison of the German and US experience

Examining parallels in the long-term evolution of the German and US university systems, this paper formulates hypotheses about the rise and decline of university entrepreneurialism at the national level. Three macro-level antecedents of university entrepreneurialism are identified: (1) decentralized competition; (2) latitude in mission and revenue mix; (3) a nationwide, diversified bidding system for the funding of large-scale university-based research. Of these, the third is real lynchpin of university entrepreneurialism. Arguing for a multidimensional understanding of such entrepreneurialism (i.e. beyond just the commercialization of scientific discoveries), the paper identifies three developments within universities emanating from a favorable national environment: (1) organizational innovations for achieving economies of scope; (2) an institutionalized capacity for strategic selection of research foci; and (3) a capacity to contribute to the development of new industries. The analysis suggests that as national university systems grow and run into cost containment problems, political pressures for reform increase, leading to system homogenization; system homogenization weakens the contextual sources of entrepreneurialism and triggers a process of decline.